Investigation of skin cancer and skin disease

皮肤癌和皮肤病的调查

• 批准号: 10487065
• 负责人: Isaac Brownell
• 金额: $ 29.4万
• 依托单位: DIVISION OF BASIC SCIENCES - NCI
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10487065
• 关键词: Adverse event; Antineoplastic Agents; Chimeric Proteins; Clinical; Clinical Management; Complex; Diagnosis; Functional disorder; Health; Immunooncology; Immunosuppression; Inflammatory; Investigation; Malignant Neoplasms; Organ; Pathology; Patients; Skin; Skin Cancer; Skin Neoplasms; United States National Institutes of Health; cancer immunotherapy; cancer therapy; immune-related adverse events; interest; novel; novel therapeutic intervention; prevent; skin disorder

We have been investigating skin diseases in patients using multiple approaches. This included studying linear inflammatory dermatoses, skin diseases arising in patients with immunosuppression, and skin adverse events related to cancer treatments. Specifically, we are investigating skin tumors arising in patients taking a novel cancer immunotherapy fusion protein as well as immune related adverse events related to immuno-oncology agents. Skin adverse events related to targeted anti-cancer agents are also of interest. These investigations are done in parallel with the clinical management of the patients' complaints. Approaches include analyzing clinical biospecimens, conducting retrospective chart reviews, and developing novel therapeutic approaches.

我们一直在使用多种方法研究患者的皮肤病。这包括研究线性炎症性皮肤病，免疫抑制患者引起的皮肤疾病以及与癌症治疗有关的皮肤不良事件。具体而言，我们正在研究服用新型癌症免疫疗法融合蛋白以及与免疫肿瘤剂有关的免疫不良事件的患者产生的皮肤肿瘤。与靶向抗癌药有关的皮肤不良事件也很感兴趣。这些调查与患者投诉的临床管理并行进行。方法包括分析临床生物测量，进行回顾性图表综述以及开发新颖的治疗方法。

项目成果

Innumerable lentigines in a mother and daughter.

母女俩身上都有无数的雀斑。

• DOI: 10.1111/pde.13701
• 发表时间: 2019
• 期刊: Pediatric dermatology
• 影响因子: 1.5
• 作者: Cardis,MichaelA;Hathaway,Olanda;Brownell,Isaac
• 通讯作者: Brownell,Isaac

BRAF Inhibitors for the Treatment of Papulopustular Eruptions from MAPK Pathway Inhibitors.

• DOI: 10.1007/s40257-020-00539-7
• 发表时间: 2020-12
• 期刊: American journal of clinical dermatology
• 影响因子: 7.3
• 作者: Wang CJ;Brownell I
• 通讯作者: Brownell I