Development and regulation of stem cell lineages in skin

皮肤干细胞谱系的发育和调节

• 批准号: 8349518
• 负责人: Isaac Brownell
• 金额: $ 44.48万
• 依托单位: DIVISION OF BASIC SCIENCES - NCI
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/8349518
• 关键词: Afferent Neurons; Cell Lineage; Cutaneous; Denervation; Development; Environment; Genetic; Hair follicle structure; Housing; Investigation; Maps; Merkel Cells; Mus; Regulation; Sensory; Signal Transduction; Skin; Stem cells; Touch sensation; Work; cell behavior; interest; novel; perineural; research study; stem cell population

Following up on prior work that identified the perineural microenvironment as a regulator of hair follicle stem cells, we have conducted further experiments investigating the long-term impact of denervation on hair follicle stem cells. Moreover, we have identified that sensory touch domes and the Merkel cells housed there are also regulated by associated sensory neurons. In other experiments we have used genetic fate mapping to demonstrate that touch domes are a novel and distinct cell lineage within the skin maintained by their own stem cell population. Finally we have conducted investigations into the association between the perivascular microenvironment and cutaneous stem cells.

跟进先前的工作，将周围的微环境确定为毛囊干细胞的调节剂，我们进行了进一步的实验，研究了神经神经膜对毛囊干细胞的长期影响。此外，我们已经确定了所包含的感觉触摸圆顶和所包含的默克尔细胞也受相关的感觉神经元的调节。在其他实验中，我们已经使用了遗传命运图来证明触摸域是由其自身的干细胞群维持的皮肤中新颖而独特的细胞谱系。最后，我们对血管周微环境和皮肤干细胞之间的关联进行了研究。