Urology Centers Program Interactions Core (U24)

泌尿中心计划互动核心 (U24)

基本信息

批准号：
10481844
负责人：
Kristina L Penniston
金额：
$ 75万
依托单位：
UNIVERSITY OF WISCONSIN-MADISON
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-09-17 至 2025-07-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10481844
关键词：
Address American Area Award Basic Science Benign Bladder Bladder Calculi Categories Cellular biology Clinical Clinical Treatment Clinical Trials Collaborations Communication Communities Congenital Abnormality Coordination and Collaboration Detection Development Diagnostic tests Disease Disease Management Disease Progression Effectiveness Environment Environmental Impact Environmental Risk Factor Etiology Evaluation Fostering Functional disorder Funding Funding Opportunities Future Genetic Genitourinary system Goals Health Home Human Resources Incontinence Individual Infection Infrastructure Interdisciplinary Study Kidney Kidney Calculi Knowledge Leadership Link Logistics Measures Mental disorders Mentors Metabolic Methodology Mission Modeling National Institute of Diabetes and Digestive and Kidney Diseases Nature Neurogenic Bladder Outcome Pain Patient-Focused Outcomes Patients Performance Persons Phenotype Physiological Physiology Population Positioning Attribute Prevention Principal Investigator Process Productivity Program Development Program Evaluation Prostatic Public Health Quality of life Research Research Personnel Research Proposals Resource Sharing Resources Risk SECTM1 gene Science Scientist Societies Symptoms System Teleconferences Training Translational Research Universities Ureter Urethra Urinary tract Urinary tract infection Urogenital Diseases Urologic Diseases Urology Wisconsin Work care outcomes career development community building comorbidity cost diagnostic criteria effective intervention effective therapy efficacy evaluation epidemiology study evidence base experience health care delivery health care disparity improved innovation interdisciplinary approach leadership development lower urinary tract symptoms male medical schools meetings member multidisciplinary outreach prevent programs reproductive organ reproductive system disorder success urologic virtual web site

项目摘要

PROJECT SUMMARY The critical need remains to advance our understanding of benign genitourinary (GU) diseases – their etiology, pathophysiology, and mechanisms of progression. The phenotypic expressions of many common benign GU diseases are yet to be defined. Clinical gaps in knowledge include objective diagnostic tests and criteria for many symptomatic benign GU conditions and the efficacy of multidisciplinary and interdisciplinary approaches to management. The impact of these conditions on other disease processes and whole body health; productivity, functioning, and quality of life; and public health overall is virtually unknown. The impact of disparities in healthcare and health outcomes on patients with benign GU disease is understudied. The potential power of prevention is unexplored. The proposed Interactions Core for the Community of NIDDK-funded benign GU Centers and Programs known as CAIRIBU (Collaborating for the Advancement of Interdisciplinary Research in Benign Urology) will foster and support integrated basic and translational science that answers critical questions in benign GU disease and builds the breadth and depth of benign urologic investigators. Our mission is to provide intellectual leadership and logistic support for the CAIRIBU Community by identifying and facilitating opportunities for cross-CAIRIBU collaboration and promoting research findings and resources to the broader benign GU research community. Specific Aims are to: 1) provide scientific leadership to the CAIRIBU Community by enabling the full potential of NIDDK staff and CAIRIBU leaders to provide guidance that results in highly meritorious convergent research and highly-trained new investigators in benign GU diseases; 2) provide leadership in team science by identifying and fostering opportunities for transdisciplinary interaction and collaboration within CAIRIBU and among the broader benign GU research community; 3) provide administrative support by building the CAIRIBU infrastructure to maximize communication, collaboration, coordination, and resource sharing; and 4) develop internal and external evaluation mechanisms to maximize the performance, transdisciplinary nature, productivity, and effectiveness of the Interactions Core and CAIRIBU Community. Our Interactions Core is led by a Principal Investigator who is an established benign GU disease investigator and has functioned in a pilot capacity as Director of Interactions for CAIRIBU since July 2018. Our Co-Investigator is an expert in the science of team science and has experience in collaboration-building and measuring collaborative science efforts. The University of Wisconsin School of Medicine and Public Health provides the ideal environment for supporting the Interactions Core due to its multiple resources. The Department of Urology is the idea “home” for the Interactions Core due to its strong commitment to and track record in benign GU research. Our Core will use innovative approaches to leverage CAIRIBU members’ common passion for addressing critical gaps in knowledge in benign GU disease.

项目摘要至关重要的需求仍然是提高我们对良性萌芽（GU）疾病的理解 - 他们的病因学，病理生理学和进展机制。许多常见良性gu的表型表达疾病尚未定义。知识的临床差距包括许多许多人的客观诊断测试和标准有症状的良性GU条件以及多学科和跨学科方法的效率管理。这些疾病对其他疾病过程和全身健康的影响；生产率，功能和生活质量；总体而言，公共卫生实际上是未知的。分布在了解良性GU病患者的医疗保健和健康结果。潜在的力量预防是出乎意料的。 NIDDK资助的良性GU社区的拟议互动核心中心和计划被称为凯里布（为跨学科研究的促进合作良性泌尿科）将培养和支持综合基础和翻译的科学，以回答关键问题在良性GU病中，建立了良性泌尿科研究人员的广度和深度。我们的使命是提供通过识别和支持，对凯里布社区的智力领导力和后勤支持跨凯布合作的机会，并促进研究结果和资源为更广泛的良性GU研究社区。具体目的是：1）为凯里布社区提供科学领导通过使NIDDK员工和Cairibu领导人的全部潜力提供指导良性GU疾病的有功融合研究和训练有素的新研究者； 2）提供通过识别和培养跨学科互动的机会，在团队科学领域的领导凯里布和更广泛的良性GU研究社区中的合作； 3）提供行政通过建立Cairibu基础架构来最大化沟通，协作，协调和资源共享； 4）开发内部和外部评估机制以最大程度地提高性能，相互作用的跨学科性质，生产力和有效性核心和凯里布社区。我们的互动核心是由一位既定的良性GU疾病研究者的首席研究员领导的自2018年7月以来，一直担任凯里布互动总监的飞行员能力。我们的共同研究员是在团队科学科学方面的经验，并具有协作建设和衡量的经验协作科学努力。威斯康星大学医学与公共卫生学院提供由于其多个资源，支持互动核心的理想环境。泌尿外科互动核心的想法是“家”，因为它坚定地承诺和记录良性GU 研究。我们的核心将采用创新的方法来利用Cairibu成员对解决良性GU病知识的关键差距。