NEW TECHNOLOGIES FOR AFRICAN SWINE FEVER VACCINES

非洲猪瘟疫苗新技术

• 批准号: 10091291
• 金额: $ 44.9万
• 依托单位: THE PIRBRIGHT INSTITUTE
• 依托单位国家: 英国
• 项目类别: EU-Funded
• 财政年份: 2024
• 资助国家: 英国
• 起止时间: 2024 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=10091291
• 关键词: NEW; TECHNOLOGIES; AFRICAN; SWINE; FEVER

VAX4ASF aims to develop a state-of-the-art platform to produce highly effective and safe vaccines against ASFV targeted for both domestic pigs and wild boars. These vaccine candidates will be designed based on an innovative and robust vaccine platform that will guarantee immune protection against the different circulating ASFV variantsin Europe, while avoiding the safety concerns arisen with the use of traditional live attenuated vaccine platforms. Vaccine candidates will effectively induce innate immune response with the adequate adaptive immunity. Moreover, the immunity induced will allow discrimination between vaccinated and infected animals, which will be monitored by complementary DIVA tests developed under the scope of the project. Given the complexity of ASFV genome and the still incomplete knowledge of the mechanisms involved in immune response to ASFV, VAX4ASF aims to further understand the molecular mechanisms of the virus and how it interacts with the host. The developed platform can be used to introduce new mutations based in this new generated knowledge which will allow to improve the efficacy and cross-protection of the vaccine prototypes. VAX4ASF will provide new virus epidemiology models and control strategies using different mathematical models, leading to a better understanding of the ASFV transmission at the wild-domestic interface. In this way, innovative policies and strategies for ASFV control and management will be generated to ensure an outstanding impact through the continuous involvement of key stakeholders as project partners (farmers, wild board managers, veterinaries, hunters, policy makers...), leading to a profound effect in animal health and worldwide economy. The project relies on a solid collaboration trajectory between leading developers of innovative Animal Health vaccines and the highest experts in ASF field at international level, including partners from Europe, USA, and Kenya for the achievement of this challenge.

VAX4ASF旨在开发一个最先进的平台，以生产针对针对家养猪和野猪的ASFV的高效和安全疫苗。这些候选疫苗的设计将基于创新且强大的疫苗平台设计，该平台将保证对欧洲不同循环的ASFV变体进行免疫保护，同时避免使用传统的直播疫苗平台引起的安全问题。候选疫苗将有效诱导具有适当适应性免疫的先天免疫反应。此外，诱导的免疫力将允许歧视接种的动物和感染动物，这些动物将通过在项目范围下开发的互补DIVA测试来监测。鉴于ASFV基因组的复杂性以及对ASFV免疫反应机制的仍然不完整的知识，VAX4ASF旨在进一步了解病毒的分子机制及其与宿主的相互作用。开发的平台可用于引入基于这种新生成的知识的新突变，这将允许提高疫苗原型的功效和交叉保护。 VAX4ASF将使用不同的数学模型提供新的病毒流行病学模型和控制策略，从而更好地理解野生动物界面处的ASFV传播。通过这种方式，将生成针对ASFV控制和管理的创新政策和战略，以确保主要利益相关者作为项目合作伙伴（农民，野生董事会经理，兽医，猎人，政策制定者...）的持续参与，从而产生重大影响，从而在动物健康和全球经济中产生深远的影响。该项目依靠创新动物健康疫苗的主要开发商与国际ASF领域的最高专家之间的扎实合作轨迹，包括来自欧洲，美国和肯尼亚的合作伙伴，以实现这一挑战。