Pathology Core

病理学核心

• 批准号: 10478906
• 负责人: JOSEPH EDWARD WILLIS
• 金额: $ 6.47万
• 依托单位: CASE WESTERN RESERVE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-09-21 至 2025-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10478906
• 关键词: Acquired Immunodeficiency Syndrome; Affect; Africa; African; Algorithms; American; Area; Artificial Intelligence; Awareness; Biological Specimen database; Biopsy; Biopsy Specimen; Cancer Etiology; Classification; Clinical; Clinical Pathology; Clinical Research; Computer software; Consensus; Consultations; Core Facility; Custom; DNA; Data; Databases; Diagnosis; Diagnostic; ERBB2 gene; Educational process of instructing; Enrollment; Epidemiology; Epidermal Growth Factor Receptor; Ethnic Origin; Europe; Expenditure; Faculty; Funding; Gene Mutation; Goals; HIV; HIV-1; Histologic; Hospitals; Image; Immunohistochemistry; Individual; Infection; Informatics; Infrastructure; Institutes; Joints; KRAS2 gene; Karnofsky Performance Status; Laboratories; Lesion; Link; Lung Adenocarcinoma; Malignant Neoplasms; Malignant neoplasm of lung; Medical Research; Medical center; Mission; Modernization; Molecular; Mutation Analysis; Oncology; Online Systems; Outcome; Pathologic; Pathology; Patients; Persons; Physicians; Population; Pulmonary Mass; RNA; Reporting; Research; Resources; Risk Factors; Sampling; Scanning; Serum; Services; Ships; Site; Slide; Somatic Mutation; Specimen; Standardization; Surgical Pathology; System; Tanzania; Techniques; Technology; Technology Transfer; Telepathology; Tissue Sample; Tissue imaging; Tissues; Translational Research; Tribes; Tumor stage; Uganda; United States National Institutes of Health; Universities; University Hospitals; Visit; Work; cancer risk; case control; demographics; design; diagnosis quality; diagnostic accuracy; digital; digital imaging; experience; flexibility; health care delivery; improved; infrastructure development; lung lesion; material transfer agreement; mortality; next generation sequencing; participant enrollment; personalized diagnostics; programs; prospective; radiological imaging; repository; routine care; success; translational goal; user-friendly

ABSTRACT – Path Core The Pathology Core will provide services to this proposal essential to the success of the projects. The Core will leverage existing technologies and infrastructure in Uganda and Tanzania as well as CWRU to provide reliable diagnoses of prospective project enrollees. The Pathology Core facilities include state of the art slide scanners which have been installed at the two African Pathology coordinating centers. The scanners are part of a large multi-institutional continent-wide program organized by the American Pathology of Clinical Pathology to improve surgical pathology diagnostic standards in Africa through a program of targeted infrastructure development. This program has enabled both teaching for faculty and residents in pathology diagnostics as well as facilitating pathology consultations across the globe. The slide scanning system and software are robust and user friendly. The program has been extremely successful and has been extensively implemented – linking multiple pathology departments in Africa to departments throughout the US and Europe. The design of the Core will facilitate rapid turnaround of pathology diagnoses through consensus. The two African center Pathology Leaders have extensive experience in the presentation of a host of non-cancerous lesions of the lung. This experience compliments that of Dr Willis, the Pathology Core Leader at CWRU, with his extensive experience in diagnostic oncology. The CWRU Pathology Core Center also has extensive experience in digital slide imaging management and translational research having extensive engagement with the CWRU Center for Computational Imaging & Personalized Diagnostics. Central to the mission of the core is standardization of diagnoses through teaching and cross center engagement. This will include cross visits by Drs Willis and Lukande. The core will also engage in important technology transfer of the technique of immunohistochemistry to both main sites in Africa. Immunohistochemistry is fundamental to modern diagnostic pathology and a pillar of diagnostic accuracy especially in oncology. Techniques to be introduced are designed to be used in low / middle resource centers and are flexible so that incremental additions to immunohistochemical panels can be performed with only minimal expenditures. The primary objective of the Core is to provide a resource that contributes significantly to the translational goals and endpoints of the individual projects, to facilitate cooperation between the three sites and to identify areas of potential further expansion of oncology–related translational research.

摘要 – 路径核心 病理学核心将为该提案提供对项目成功至关重要的服务。 该核心还将利用乌干达和坦桑尼亚的现有技术和基础设施 作为 CWRU 为潜在项目参与者提供可靠的诊断病理学核心。 设施包括最先进的幻灯片扫描仪，已安装在两个非洲 这些扫描仪是整个大陆大型多机构的一部分。 美国临床病理学协会组织的旨在改善外科病理学的计划 通过有针对性的基础设施发展计划提高非洲的诊断标准。 该计划使教师和住院医师能够进行病理诊断以及 载玻片扫描系统和软件可促进全球病理学咨询。 该程序非常成功且用户友好。 实施——将非洲的多个病理科室与美国各地的科室连接起来 核心的设计将促进病理诊断的快速周转。 两位非洲中心病理学领导者在这方面拥有丰富的经验。 这一经验与肺部非癌性病变的表现相得益彰。 Willis 博士是 CWRU 病理学核心领导者，在诊断方面拥有丰富的经验 CWRU 病理学核心中心在数字切片方面也拥有丰富的经验。 与 CWRU 广泛合作的影像管理和转化研究 计算成像和个性化诊断中心是核心使命的核心。 是通过教学和跨中心参与实现诊断标准化。 威利斯博士和卢坎德博士的交叉访问还将进行重要的技术转让。 免疫组织化学技术在非洲的两个主要地点是。 现代诊断病理学的基础和诊断准确性的支柱，特别是在 所引进的技术旨在用于低/中资源中心。 并且很灵活，可以对免疫组化面板进行增量添加 核心的主要目标是提供一种资源， 对各个项目的转化目标和终点做出了重大贡献， 促进三个地点之间的合作并确定潜在进一步扩展的领域 肿瘤学相关的转化研究。