Demonstrating the potential for portable detection of bird flu.

展示便携式检测禽流感的潜力。

• 批准号: 10090901
• 金额: $ 26.62万
• 依托单位: B G RESEARCH LIMITED
• 依托单位国家: 英国
• 项目类别: Collaborative R&D
• 财政年份: 2024
• 资助国家: 英国
• 起止时间: 2024 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=10090901
• 关键词: Demonstrating; potential; portable; detection; bird

Project aim is to provide capability for early in-field direct testing of unprocessed biological samples e.g. swabs and blood for economically important veterinary pathogens, in this case screening swab samples taken from the beaks and cloaca of birds for detecting "bird flu". Initially we aim to support existing lab testing and ultimately explore the potential for moving tests into the field or farm.BG Research have developed a novel method and instrument for performing sensitive in-field molecular diagnostic tests for the detection of viruses without the requirement for expert scientists or shipping of samples to a test-lab and utilising the gold-standard PCR test methodology. Tests could be performed at ports of entry to prevent diseases being imported, on farms or at slaughterhouses to support surveillance/quarantine and emergency response.By performing rapid, sensitive, and cost-effective tests wherever required, the BGR technology could help protect the UK by preventing potential importation of infectious diseases at entry points and expedite outbreak response where incursions require rapid disease response activities. For example, the outbreaks of FMD in the UK cost the economy £10bn and COVID-19 is thought to have originated from wildlife. Such technology could assist Defra to more effectively monitor transboundary veterinary diseases and provide real-time data to contribute to the control of these diseases, reducing the socio-economic impacts of future outbreaks.We will develop the platform from a lab-based technology demonstrator into a late-stage prototype capable of being operated off-grid and moving the technology closer to the intended portable testing market. Test development assessment will be undertaken at the Animal and Plant Health Agency (APHA) where the necessary scientific expertise and facilities required to work with these pathogens are available. Bird flu has been in the news continually for the past few years and over 8.5 million UK birds have been lost/culled in that period, the impact of this has been seen by the consumer by the lack of eggs in the supermarket and turkeys for Christmas. A novel tool such as this could assist in future outbreak management -- reducing the economic burden and reducing the risk of bird flu becoming a human pathogen.The platform and associated validated tests would be made in the UK and marketed globally by BG, supporting growth and employment in UK Life Sciences and supply chains, while ensuring the UK is better prepared to respond to future epidemics of important human and animal pathogens.

该项目的目标是提供对未处理的生物样本（例如经济上重要的兽医病原体）进行早期现场直接检测的能力，在这种情况下，我们首先筛选从鸟类的喙和泄殖腔采集的拭子样本以检测“禽流感”。旨在支持现有实验室测试的进展，并最终探索在田间或农场进行测试的潜力。BG Research 开发了一种新颖的方法和仪器，用于执行敏感的现场分子诊断测试，以检测病毒，而无需专家科学家或将样本运送到测试实验室并利用黄金标准 PCR 测试方法可以在入境口岸、农场或屠宰场进行测试，以防止疾病输入，以支持监测/检疫和应急响应。 BGR 技术可以在需要的地方进行快速、灵敏且经济高效的检测，可以通过在入境点防止传染病的潜在输入来帮助保护英国，并在需要快速疾病应对活动的情况下加快疫情应对措施，例如口蹄疫爆发。在英国经济损失达 100 亿英镑，而 COVID-19 被认为源自野生动物，此类技术可以帮助 Defra 更有效地监测跨境兽医疾病，并提供实时数据，为控制这些疾病做出贡献，从而减少社会经济损失。我们将把该平台从基于实验室的技术演示器开发为能够离网运行的后期原型，并使该技术更接近预期的便携式测试市场。测试开发评估将在现场进行。动植物卫生署(APHA) 在过去的几年中，禽流感问题不断出现在新闻中，在此期间，已有超过 850 万只英国鸟类丢失/扑杀，而处理这些病原体所需的必要科学专业知识和设施已经具备。消费者已经从超市里缺少鸡蛋和圣诞节火鸡中看到了这一点，这样的新工具可以帮助未来的疫情管理——减轻经济负担并降低禽流感成为人类病原体的风险。该平台和相关的验证测试将在英国并由 BG 在全球销售，支持英国生命科学和供应链的增长和就业，同时确保英国更好地应对未来重要人类和动物病原体的流行病。