Translational Core

翻译核心

• 批准号: 10477361
• 负责人: Aaron Ermel
• 金额: $ 7.43万
• 依托单位: INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-09-07 至 2025-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10477361
• 关键词: AIDS related cancer; AIDS/HIV problem; Acquired Immunodeficiency Syndrome; Africa; Africa South of the Sahara; African; Age; American; Area; Behavioral; Biological; Biology; Biometry; CD4 Lymphocyte Count; Cancer Burden; Caring; Cessation of life; Clinical; Collaborations; Consent; Country; Data; Databases; Developed Countries; Development; Diagnosis; Disease; Environment; Environmental Risk Factor; Epidemiology; Fostering; Funding; Goals; HIV; HIV Infections; HPV-High Risk; Healthcare; Home; Human; Human Papilloma Virus-Related Malignant Neoplasm; Human Papillomavirus; Human papilloma virus infection; Human papillomavirus 16; Immunohistochemistry; Immunologics; Incidence; Infection; Infrastructure; Institutes; Institution; International; Investigation; Kenya; Knowledge; Laboratories; Lesion; Link; Malignant Neoplasms; Malignant neoplasm of cervix uteri; Molecular; Oncogenic; Oncology; Outcomes Research; Participant; Pathology; Patients; Pilot Projects; Population; Prevalence; Prevention; Prevention program; Process; Research; Research Personnel; Research Support; Resources; Risk; Role; Sampling; Science; Scientist; Secure; Services; Site; Specimen; Techniques; Technology; Testing; Tissues; Total Quality Management; Training; Uganda; Universities; Viral; Woman; Work; antiretroviral therapy; base; biobank; cancer care; career; chronic infection; data management; data sharing networks; epidemiologic data; genome sequencing; improved; improved outcome; low and middle-income countries; member; next generation sequencing; pathogen; population health; premalignant; programs; prospective; reconstitution; routine screening; screening; screening program; skills; treatment program; whole genome

Abstract The majority of new cancers that were diagnosed and the majority of cancer related deaths worldwide occurred in low-and-middle income countries (LMICs) in 2018. This is in striking contrast to more developed countries where cancer care and outcomes are improving. One driver of this difference is the human immunodeficiency virus (HIV) which predisposes those who are infected to develop certain cancers. Despite the burden of cancer in LMICs, there is a lack of organized research and support services to see to the successful outcomes of research programs. In the case of cervical cancer, the confluence of high HIV prevalence, disparity in resources and lack of infrastructure in research results in high burden of what could be a preventable disease. The overall objective of this proposal is to improve the screening, prevention, and knowledge of the mechanisms of cancer development as it relates to cervical cancer in Kenyan and Ugandan women. In HIV-infected women and uninfected women, cervical cancer is caused by persistent infection of human papillomavirus (HPV). Though infection with HPV is relatively common, only a small percentage of women will develop cervical cancer. Environmental factors unique to Kenya and Uganda may also contribute to the increase in cervical cancer burden in this area of the world. There is also a lack of understanding of the human molecular mechanisms and viral (HPV and HIV) work together to promote cancer development. The investigation of how all of these factors (environmental, viral, human behavioral and biological) interact in Kenyan and Ugandan women is the overall objective of this program project. The role of the Translational Biology Core (TBC) is to support the scientific endeavors outlined in the three projects and to provide an environment conducive to the training of new African scientists in the field of HIV-associated malignancies. Not only will the TBC process and store samples collected during the study period, it will also continue augment the biorepository that will provide samples for ongoing research in Oncology in East Africa. As a part of this proposal, the TBC will be improving data sharing resources in partnership with the International Epidemiology Databases to Evaluate AIDS in East Africa (IeDEA-EA) so that data generated in Kenya and Uganda can be freely shared among members of the consortium. In doing so, the care provided to women in Kenya and Uganda with cervical cancer will improve.

抽象的 全世界大多数被诊断出的新癌症和大多数与癌症有关的死亡发生了 在2018年低中收入国家（LMIC）中。这与更发达国家形成鲜明对比 癌症护理和结果正在改善的地方。这种差异的驱动力是人类免疫缺陷 病毒（艾滋病毒）使人容易受感染的人发展某些癌症。尽管癌症负担 在LMIC中，缺乏有组织的研究和支持服务，无法看到 研究计划。在宫颈癌的情况下，高艾滋病毒流行率的汇率，资源差异 研究中缺乏基础设施会导致可预防疾病的高负担。总体 该建议的目的是改善癌症机制的筛查，预防和知识 与肯尼亚和乌干达妇女的宫颈癌有关的发展。在艾滋病毒感染的妇女中 未感染的妇女，宫颈癌是由人乳头瘤病毒（HPV）持续感染引起的。尽管 HPV感染相对普遍，只有一小部分女性会患上宫颈癌。 肯尼亚和乌干达独有的环境因素也可能导致宫颈癌负担的增加 在世界这个地区。也缺乏对人分子机制和病毒的了解 （HPV和HIV）共同促进癌症发展。对所有这些因素的调查 （环境，病毒，人类行为和生物学）在肯尼亚和乌干达妇女中相互作用是总体 该计划项目的目标。转化生物学核心（TBC）的作用是支持科学 在这三个项目中概述的努力，并提供有利于培训新非洲的环境 与HIV相关的恶性肿瘤领域的科学家。 TBC不仅可以收集样品并存储样品 在研究期间，它还将继续增加生物座位，该生物座将为正在进行的样本提供 东非肿瘤学研究。作为本提案的一部分，TBC将改善数据共享资源 与国际流行病学数据库合作评估东非的艾滋病（IEDEA-EA），以便 在肯尼亚和乌干达产生的数据可以在财团的成员之间自由共享。这样， 为肯尼亚和乌干达宫颈癌的妇女提供的护理将有所改善。