Allergen Exposure Reduction as a Disease-Modifying Strategy in Allergen-Sensitized Children with Asthma

减少过敏原暴露作为过敏原敏感哮喘儿童的疾病缓解策略

• 批准号: 10474283
• 负责人: Torie Grant
• 金额: $ 19.82万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-01 至 2026-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10474283
• 关键词: Acids; Address; Adult; Affect; Allergens; Allergic Disease; Arachidonic Acids; Asthma; Biological Markers; Biological Specimen Banks; Biometry; Bronchodilator Agents; Characteristics; Child; Childhood; Childhood Asthma; Chronic Obstructive Pulmonary Disease; Clinical; Clinical Investigator; Data; Data Analyses; Data Collection; Development Plans; Dinoprostone; Disease; Disease Progression; Doctor of Philosophy; Education; Enrollment; Environmental Exposure; Environmental Health; Environmental Risk Factor; Epidemiology; Exposure to; Extrinsic asthma; Fibrosis; Foundations; Grant; Growth; Home; Immunologist; Impairment; Inflammatory; Insulin-Like Growth-Factor-Binding Proteins; Internist; Interstitial Collagenase; Intervention; Intervention Trial; Knowledge; Leukotriene B4; Leukotriene C4; Link; Long-Term Effects; Lung; Lung diseases; MMP2 gene; MMP9 gene; Mass Spectrum Analysis; Measures; Medicine; Mentored Patient-Oriented Research Career Development Award; Mentors; Mentorship; Morbidity - disease rate; Mus; Observational Study; Obstructive Lung Diseases; Outcome; Parents; Participant; Pediatrics; Pharmaceutical Preparations; Physicians; Plasminogen Activator Inhibitor 1; Prospective cohort; Public Health; Public Health Schools; Pulmonary Fibrosis; Pulmonary Function Test/Forced Expiratory Volume 1; Pulmonary function tests; Reporting; Research; Risk; Risk Factors; Role; School-Age Population; Scientist; Serum; Spirometry; Testing; Tobacco; Training; Universities; Vascular Endothelial Growth Factors; Wood material; Work; biomarker discovery; biomarker-driven; career; career development; clinical effect; cohort; design; experience; functional decline; hepatoma-derived growth factor; improved; indoor allergen; insight; lipid mediator; lipoxin A4; medical schools; modifiable risk; mortality risk; mouse allergen; multiplex assay; novel; pediatrician; periostin; professor; programs; pulmonary function; pulmonary function decline; skills; study population; success; targeted biomarker; trend

PROJECT ABSTRACT/SUMMARY: Torie Grant, MD, MHS is an Assistant Professor of Pediatrics and Medicine at Johns Hopkins University School of Medicine. Dr. Grant seeks a K23 Mentored Patient-Oriented Research Career Development Award in order to obtain the skills, knowledge, and mentored research experience that are the essential foundation for a career as an independent clinical investigator studying pediatric determinants of adult lung disease. Dr. Grant's career development plan includes the pursuit of a PhD in epidemiology at the Johns Hopkins Bloomberg School of Public Health. Her mentorship team includes established physician scientists with decades of research and mentorship experience: Dr. Robert Wood (co-primary mentor) has over 30 years of pediatric asthma research and mentoring experience; Dr. Elizabeth Matsui (co-primary mentor) has been the PI of multiple pediatric asthma studies focusing on environmental exposures; Dr. Robert Wise is an expert in pulmonary function testing and asthma clinical trialist; Dr. Corinne Keet is an expert is asthma epidemiology and environmental risks for asthma and allergic diseases; Dr. Allen Everett is an expert in biomarker discovery; and Dr. Roger Peng is an environmental biostatistician with expertise in environmental exposures and health outcomes. Current pediatric asthma therapies are effective in achieving asthma control, but have little effect on the progression of asthma into adulthood. Emerging evidence suggests that indoor allergen exposure may have deleterious effects on lung function trajectory from childhood to adulthood among allergen-sensitized children with asthma. Aim 1 of this proposal seeks to examine the long-term effects of indoor allergen exposure and sensitization on lung function growth and risk of adult obstructive lung disease. Aim 2 will examine the effects of indoor allergen exposure reduction on lung function growth. Aim 3 will explore the relationship between indoor allergen exposure reduction and hypothesis-driven biomarkers of pulmonary fibrosis and remodeling. These aims will add critical knowledge to our understanding of the role of indoor allergen exposure in lung function growth, conceptualizing allergen reduction as a disease-modifying therapy. Dr. Grant's background as an internist, pediatrician, and allergist-immunologist, with training in epidemiology and biostatistics, makes her the ideal candidate to study adult lung function outcomes in pediatric asthma.

项目摘要/摘要： MHS医学博士Torie Grant是Johns Hopkins University的儿科和医学助理教授 医学院。 Grant博士寻求K23指导的以患者为导向的研究职业发展奖 为了获得技能，知识和指导的研究经验，这是必不可少的基础 研究成人肺部疾病的小儿决定因素的独立临床研究者的职业。博士 格兰特的职业发展计划包括在约翰·霍普金斯（Johns Hopkins）攻读流行病学博士学位 彭博公共卫生学院。她的指导团队包括 数十年的研究和指导经验：罗伯特·伍德博士（联合主导）拥有30多年的历史 小儿哮喘研究和指导经验；伊丽莎白·马苏（Elizabeth Matsui）博士（联合主导）一直是 多个小儿哮喘研究的PI，重点是环境暴露；罗伯特·怀斯（Robert Wise）博士是专家 肺功能测试和哮喘临床试验师； Corinne Keet博士是专家是哮喘流行病学 以及哮喘和过敏性疾病的环境风险；艾伦·埃弗里特（Allen Everett）博士是生物标志物发现专家； 罗杰·彭（Roger Peng）博士是一个环境生物统计学家，在环境暴露和健康方面具有专业知识 结果。 当前的儿科哮喘疗法可有效地控制哮喘，但对 哮喘的成年发展。新兴证据表明，室内过敏原暴露可能有 过敏原敏感的儿童对从儿童期到成年的肺功能轨迹的有害影响 哮喘。该提案的目标1旨在检查室内过敏原暴露和 对肺功能生长和成人阻塞性肺部疾病风险的敏感性。 AIM 2将检查效果 室内过敏原暴露于肺功能生长。 AIM 3将探索 室内过敏原暴露减少和假说驱动的肺纤维化和重塑的生物标志物。 这些目标将为我们对室内过敏原暴露在肺中的作用的理解增加关键知识 功能生长，概念化过敏原降低为改良疾病的疗法。格兰特博士的背景 内科医生，儿科医生和过敏者免疫学家，接受流行病学和生物统计学的培训，使她成为 研究小儿哮喘中成人肺功能结果的理想候选者。