RL5: Research Education Core

RL5：研究教育核心

• 批准号: 10468313
• 负责人: Maureen Katheleen O'Connor
• 金额: $ 13.31万
• 依托单位: BOSTON UNIVERSITY MEDICAL CAMPUS
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-08-15 至 2026-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10468313
• 关键词: Alzheimer' s Disease; Alzheimer' s disease related dementia; Animals; Attention; Basic Science; Behavioral; Biological Markers; Biometry; Boston; Clinical; Clinical Data; Clinical Research; Clinical Sciences; Cohort Studies; Data; Data Set; Dementia; Detection; Enrollment; Ensure; Environment; Faculty; Feedback; Framingham Heart Study; Functional disorder; Genetic Markers; Goals; Instruction; Longitudinal cohort study; Mentors; Mentorship; Monitor; Nerve Degeneration; Neurodegenerative Disorders; Pathology; Population; Population Heterogeneity; Research; Research Personnel; Research Training; Resources; Risk Factors; Rotation; Scientist; Structure; Symptoms; Training; Training and Education; Translational Research; Underrepresented Populations; Universities; Vulnerable Populations; career; chronic traumatic encephalopathy; cohort; data management; digital; early-career faculty; education research; experience; fundamental research; human subject; interest; knowledge base; next generation; novel therapeutics; programs; responsible research conduct; skills; symposium

Summary/Abstract Research Education Component (REC) Program A major research focus of the BU ADRC is to conduct cutting edge research on Alzheimer's disease (AD) and AD related dementias (ADRD), including chronic traumatic encephalopathy (CTE), with special attention to identifying the differences and similarities between groups, leveraging the BU ADRC's data-rich environment featuring access to world-class cohorts such as the Framingham Heart Study, the DIAGNOSE CTE Study, next-generation digital and biomarker datasets, as well as diverse and inclusive research populations found in the BU ADRC's Hope Study. The REC will use the unique expertise of the BU ADRC and affiliated faculty to provide advanced research training as it relates to common themes of neurodegeneration in AD/ADRD and related investigative treatments. The REC program goals are: (1) to maintain 4 postdoctoral/early-career trainees for 2-year terms among 3 different tracks: (a) a basic science track; (b) a clinical science track; and (c) a data management and biostatistics track; (2) to ensure at least half of REC trainees are underrepresented groups and (3) to enable trainees to transition to independence. The scientific and research training of the REC will be focused on (1) AD, including its pathology, pathophysiology, risk factors, genetics, biomarkers, clinical symptoms, and behavioral manifestations, and (2) common and distinct themes related to neurodegeneration, including how pathology, pathophysiology, risk factors, genetics, biomarkers, clinical symptoms, and behavioral manifestations of AD compare and contrast to other ADRD. The BU ADRC REC is committed to developing a diverse cohort of independent AD/ADRD researchers from advanced trainees and early-career faculty, savvy in working across rich cohort studies to unlock central mechanisms in the detection and treatment of dementia. We will achieve this objective, and serve the other Cores in this application, by providing didactic and practical training in essential basic and translational research and clinical fundamentals of AD/ADRD, training in research fundamentals and critical professional skills, with an emphasis on the responsible conduct of research with animal and human subjects, and diverse and vulnerable populations, and high quality, individualized, detailed mentorship to prepare a diverse cohort of trainees for independent investigator status in AD/ADRD research.

摘要/摘要 研究教育部分（REC）计划 BU ADRC 的一个主要研究重点是对阿尔茨海默病进行前沿研究 疾病 (AD) 和 AD 相关痴呆 (ADRD)，包括慢性创伤性脑病 （CTE），特别注意识别群体之间的差异和相似之处， 利用 BU ADRC 的数据丰富的环境，可以访问世界一流的队列，例如 例如 Framingham 心脏研究、DIAGNOSE CTE 研究、下一代数字和 生物标志物数据集，以及 BU 中发现的多样化且包容性的研究群体 ADRC 的希望研究。 REC 将利用 BU ADRC 及其附属机构的独特专业知识 教师提供与共同主题相关的高级研究培训 AD/ADRD 中的神经变性和相关的研究治疗。 REC 计划目标 是： (1) 在 3 个不同的领域维持 4 名博士后/早期职业培训生，为期 2 年 轨道：(a) 基础科学轨道； (b) 临床科学方向； (c) 数据管理和 生物统计学轨道； (2) 确保至少一半的 REC 学员属于代表性不足的群体，并且 (3)使学员过渡到独立。科学研究培训 REC将重点关注（1）AD，包括其病理学、病理生理学、危险因素、遗传学、 生物标志物、临床症状和行为表现，以及（2）共同点和独特点 与神经变性相关的主题，包括病理学、病理生理学、危险因素、 AD 的遗传学、生物标志物、临床症状和行为表现进行比较和 与其他 ADRD 相比。 BU ADRC REC 致力于培养多元化的独立 AD/ADRD 群体 研究人员来自高级实习生和早期职业教师，精通跨富裕阶层的工作 队列研究旨在揭示痴呆症检测和治疗的核心机制。我们将 实现这一目标，并通过提供教学和服务来服务于该应用程序中的其他核心 基本基础和转化研究以及临床基础的实践培训 AD/ADRD，研究基础知识和关键专业技能培训，重点是 负责任地对动物和人类受试者进行研究，以及多样化和 弱势群体，以及高质量、个性化、详细的指导，以准备 AD/ADRD 研究中独立研究者身份的不同学员群体。