Chemotactic Cytokines Gordon Research Conference and Seminar

趋化细胞因子戈登研究会议及研讨会

• 批准号: 10468353
• 负责人: Marcus Thelen
• 金额: $ 1.1万
• 依托单位: GORDON RESEARCH CONFERENCES
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-04-11 至 2023-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10468353
• 关键词: Address; Area; Asthma; Atmosphere; Attention; Autoimmune; Autoimmunity; Basic Science; Biochemical; Biological; CD4 Antigens; CD4 Positive T Lymphocytes; Cell Adhesion; Cells; Chemotaxis; Clinical; Communicable Diseases; Complement; Country; Cytokine Gene; Degenerative Disorder; Development; Developmental Biology; Disabled Persons; Discipline; Disease; Drug Industry; Embryonic Development; Europe; Event; Exposure to; Feedback; Fees; Fostering; Funding; G-Protein-Coupled Receptors; GTP-Binding Proteins; Gender; Gene Family; Generations; HIV; Health; Homeostasis; Human; Human Genome; Human Pathology; Immunologic Surveillance; Immunology; Industry; Infection; Inflammation; Inflammatory; Inflammatory Bowel Diseases; Interdisciplinary Study; International; Interruption; Jaw; Knowledge; Length; Leukocyte Trafficking; Leukocytes; Light; Location; Malignant Neoplasms; Mediating; Mentors; Minority Participation; Molecular; Multiple Sclerosis; Neurobiology; Oral; Participant; Pathologic Processes; Pathology; Pharmaceutical Preparations; Physiological Processes; Positioning Attribute; Postdoctoral Fellow; Proteins; Psoriatic Arthritis; Published Comment; Request for Applications; Research; Research Personnel; Research Project Grants; Rheumatoid Arthritis; Role; Scientist; Senior Scientist; Series; Social Interaction; Specialist; Structure; Switzerland; System; Techniques; Therapeutic; Time; Training; United States National Institutes of Health; Vertebrates; Virus; Woman; Work; base; carcinogenesis; career; cell motility; chemokine; chemokine receptor; clinically relevant; design; drug development; experience; graduate student; immune function; intercellular communication; interest; lectures; meetings; new therapeutic target; next generation; novel; novel therapeutic intervention; novel therapeutics; pandemic disease; peer; posters; programs; receptor; success; symposium; tool; translational potential; treatment strategy; wound

PROJECT SUMMARY: The chemokine system consists of chemokines, their cognate G-protein coupled receptors and their atypical receptors, which are structurally related but do not couple to G-proteins. It is an unusually diverse and promiscuous network involved in almost every physiological process of jawed vertebrates. The complexity requires studying the system from different viewpoints and with different tools, approaches and techniques. A prominent feature of the chemokine system is to guide cell migration and position cells in specific niches. The 2022 Gordon Research Conference (GRC) on Chemotactic Cytokines: "Orchestrating cell migration and localization in health and disease" is an internationally renowned meeting dedicated to deconvolute the mechanisms and unveil new functions of the chemokine system. This will be the 14th edition of the Chemokine GRC, which has been held every other year since 1994 (except for 2020), when chemokines first emerged as the largest cytokine gene family in the human genome. As in the past, the Chemotactic Cytokine GRC 2022 will attract scientists from diverse biomedical disciplines to discuss the latest unpublished results that will tackle many aspects of chemokine-related research. The proposed program calls on outstanding specialist that will present new findings, new concepts and potential implications, including translational perspectives. Hence, the meeting will cover basic biochemical and biological aspects of chemokines related to their contributions to cell migration, immune function, and their role in inflammation, infection, autoimmunity and cancer. New developments in potential drugs and disease treatment strategies will also be discussed. The GRC will, like at the recent four editions, be accompanied by a satellite Gordon Research Seminar (GRS) on Chemotactic Cytokines. The GRS "Exploring the chemokine system: from structures to functions" is particularly designed for young scientists, graduate students and early postdocs. These next generation scientists will present their work and receive feedback on their research projects from their peers and from a selected panel of senior internationally renowned field experts and at the same time the forum will promote integration and networking within the field of chemokine research. NIH funding is requested to provide partial support for registration of the participants. We fully anticipate that the scientific discussions, research talks, poster sessions, and informal interactions between the participants of this conference will contribute to advancing our understanding of molecular mechanisms of chemokine involvement in health and disease. The conference will foster the development of new collaborative projects, which will lead to new discoveries and ultimately new therapies and approaches to treat debilitating human pathologies, including inflammatory, autoimmune, infectious diseases and cancer.

项目概要： 趋化因子系统由趋化因子、其同源 G 蛋白偶联受体及其 非典型受体，其结构相关但不与 G 蛋白偶联。这是一个不同寻常的 多样化且混杂的网络参与了有颌脊椎动物的几乎每一个生理过程。 复杂性需要从不同的角度和使用不同的工具来研究系统， 方法和技术。趋化因子系统的一个突出特点是引导细胞迁移和 将细胞定位在特定的壁龛中。 2022 年戈登趋化研究会议 (GRC) 细胞因子：“协调健康和疾病中的细胞迁移和定位”是一项国际 著名的会议致力于简化机制并揭晓新的职能 趋化因子系统。这将是 Chemokine GRC 的第 14 届，该活动每隔一届举办一次 自 1994 年（2020 年除外）以来的一年，趋化因子首次作为最大的细胞因子基因家族出现 在人类基因组中。与过去一样，趋化细胞因子 GRC 2022 将吸引来自以下国家的科学家： 不同的生物医学学科讨论最新的未发表的结果，这些结果将解决生物医学的许多方面 趋化因子相关研究。拟议的计划呼吁杰出的专家提出新的 发现、新概念和潜在影响，包括转化观点。因此， 会议将涵盖趋化因子的基本生化和生物学方面及其贡献 细胞迁移、免疫功能及其在炎症、感染、自身免疫和癌症中的作用。 还将讨论潜在药物和疾病治疗策略的新进展。 GRC 与最近的四届会议一样，将伴随一个卫星戈登研究研讨会（GRS） 趋化细胞因子。 GRS“探索趋化因子系统：从结构到功能”是 专为年轻科学家、研究生和早期博士后设计。这些下一代 科学家将展示他们的工作并从同行那里获得关于他们研究项目的反馈 由精选的国际知名领域资深专家组成的小组，同时论坛 将促进趋化因子研究领域的整合和网络化。请求 NIH 资助 为参与者的注册提供部分支持。我们完全预计科学 讨论、研究讲座、海报会议以及参与者之间的非正式互动 会议将有助于增进我们对趋化因子分子机制的理解 参与健康和疾病。会议将促进新合作的发展 项目，这将带来新的发现并最终带来新的疗法和治疗方法 使人类衰弱的疾病，包括炎症、自身免疫性疾病、传染病和癌症。