Center for Excellence in Host Pathogen Interactions

宿主病原体相互作用卓越中心

• 批准号: 10462724
• 负责人: David S. Bradley
• 金额: $ 207.32万
• 依托单位: UNIVERSITY OF NORTH DAKOTA
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-05-13 至 2026-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10462724
• 关键词: Acute; Affect; Area; Bacterial Infections; Behavior Disorders; Big Data; Businesses; Centers of Research Excellence; Communicable Diseases; Communities; Core Facility; Data Analyses; Development; Disease; Ensure; Epigenetic Process; Extramural Activities; Faculty; Flow Cytometry; Focus Groups; Food Hypersensitivity; Fostering; Funding; Genomics; Giardia; Goals; Grant; Growth; Health; Histology; Human; Image; Immune response; Individual; Infection; Inflammation; Inflammatory; Infrastructure; Interdisciplinary Study; International; Intestines; Investigation; Light; Mentors; Mucous Membrane; Neurodegenerative Disorders; Parasites; Parasitic Diseases; Parasitic infection; Phase; Predisposition; Process; Program Development; Publications; Research; Research Infrastructure; Research Personnel; Research Project Grants; Respiratory syncytial virus; SARS-CoV-2 infection; Science; Scientist; Stream; Support Groups; Surface; Talents; Time; Viral; Virus Diseases; Vision; airway epithelium; anticancer research; career development; career networking; chronic inflammatory disease; cohesion; design; dysbiosis; equipment acquisition; experimental study; gastrointestinal; gut microbiota; gut-brain axis; host-microbe interactions; innovation; interest; microbiome; multidisciplinary; novel; pathogen; programs; respiratory; success

Summary This COBRE Phase 2 application proposes continued support of the UND Center for Excellence in Host- Pathogen interaction (HPI). The long-term goal of this center is to develop a deeper understanding of host responses to viral, bacterial and parasitic insults leading to acute and chronic inflammatory diseases. The vision of this Center is to continue to inspire interest in the study of host-microbe interaction and perform paradigm- shifting science that supports the notion that disease development is an interplay of the interaction between a susceptible host, foreign insult and conducive microenvironment. In Phase 1 this center made significant progress by expanding the number of investigators studying various aspects of infectious and inflammatory diseases (from the initial group of 9 labs to now 18 labs). Since the funding of Phase 1 in 2016, this core group of COBRE investigators has made significant contributions to the field by producing 169 publications, $23,617,386 in extramural funding, and 74 speaking engagements (local, national and international). With the project leader graduation success rate of 80% (4 out 6 investigators graduated with R01 funding) in Phase 1, this Center will continue to promote research on host-microbe interaction by: 1) bringing together four young investigators working cohesively in an integrative, collaborative, and multidisciplinary manner on research encompassing extremely timely COVID-19 infection, intestinal dysbiosis in food allergy, gastrointestinal parasitic infection, and viral interaction with respiratory epithelium; 2) enhance the innovative research capabilities of the Center by supporting 3 existing Phase 1 Core facilities; 3) establishing a new Computational Data Analysis Core to meet the emerging requirements of COBRE investigators; and 4) attract new investigators to the group by supporting pilot grant mechanisms. The ultimate goal is to transition the HPI COBRE to a sustainable, well- organized academic center which will serve as a conduit for increased interaction between investigators from diverse backgrounds with a thematic interest in pursuing research on various aspects of host-microbe interactions.

概括 该 COBRE 第 2 阶段申请建议继续支持 UND 卓越中心在主机方面的支持 病原体相互作用 (HPI)。该中心的长期目标是加深对主机的了解 对病毒、细菌和寄生虫损伤的反应，导致急性和慢性炎症性疾病。愿景 该中心的目的是继续激发人们对宿主-微生物相互作用研究的兴趣并执行范式- 科学的转变支持这样一种观点，即疾病的发展是多种因素之间相互作用的相互作用 易感宿主、外来侮辱和有利的微环境。在第一阶段，该中心取得了重大进展 通过扩大研究感染性和炎症各个方面的研究人员数量来取得进展 疾病（从最初的 9 个实验室到现在的 18 个实验室）。自 2016 年第一阶段融资以来，该核心小组 的 COBRE 研究人员发表了 169 篇出版物，为该领域做出了重大贡献， 23,617,386 美元的外部资金，以及 74 次演讲活动（本地、国家和国际）。随着 第一阶段项目负责人毕业成功率达 80%（6 名研究者中有 4 名通过 R01 资助毕业）， 该中心将通过以下方式继续促进宿主-微生物相互作用的研究：1）汇集四位年轻的 研究人员以综合、协作和多学科的方式团结一致地开展研究 包括极其及时的 COVID-19 感染、食物过敏引起的肠道菌群失调、胃肠道寄生虫 感染以及病毒与呼吸道上皮的相互作用； 2）提升科研创新能力 中心支持3个现有的一期核心设施； 3）建立新的计算数据分析核心 满足 COBRE 研究人员的新要求； 4）通过以下方式吸引新的研究人员加入该小组 支持试点补助机制。最终目标是将 HPI COBRE 转变为可持续的、良好的 组织的学术中心将作为增加来自不同国家的研究人员之间互动的渠道 具有对宿主微生物各个方面进行研究的不同背景和主题兴趣 互动。