ICSC Applied Research Project

ICSC应用研究项目

基本信息

批准号：
10458466
负责人：
IAN F KORF
金额：
$ 8.38万
依托单位：
UNIVERSITY OF CALIFORNIA AT DAVIS
依托单位国家：
美国
项目类别：
财政年份：
2011
资助国家：
美国
起止时间：
2011-07-01 至 2026-06-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10458466
关键词：
Accountability Address Affect Animal Model Applied Research Archives Back Basic Science Clustered Regularly Interspaced Short Palindromic Repeats Communities Costs and Benefits Data Databases Disease Fingerprint Future Genetic Diseases Genome Health Human Informatics Journals Learning Longevity Measurement Measures Mus Mutant Strains Mice NIH Mouse NON Mouse Ontology Paper Physiological Publications Recording of previous events Reproducibility Reproduction Research Research Design Research Personnel Research Project Grants Research Project Summaries Research Support Resolution Resources Scientist Services Standard Model Technology Translational Research United States National Institutes of Health cancer genetics comparative cost design health science research improved interest invention mouse model pathogen programs repository

项目摘要

PROJECT SUMMARY – RESEARCH The NIH MMRRC archives, curates, and distributes mouse models of scientific interest to the research community at minimal cost. While this organization should accelerate the pace of research and provide greater rigor and reproducibility, there have been no studies that show how successful the program is. The objective of the proposed Applied Research Project is to better understand the specific impact of the MMRRC on research. Aim #1 proposes to produce high resolution measurements of how the MMRRC products are used across the research spectrum as well as details about the users. These studies will indicate the breadth and depth of research supported by the MMRRC. Aim #2 proposes to measure the impact of the MMRRC by asking questions such as “are MMRRC users more effective scientists?” This kind of question can be answered by comparing MMRRC products and users to non-MMRRC products and non-users. Aim #3 proposes to develop research fingerprints which assist in uniquely identifying research products and authors in the absence of the unique identifiers provided by RRIDs and ORCID iDs. This will allow us to study the history of MMRRC impact. Research fingerprints are also useful in clustering researchers by their interests, which will allow us to proactively suggest mouse models to scientists with shared research interests.

项目概要——研究 NIH MMRRC 存档、管理和分发对研究具有科学意义的小鼠模型同时该组织应该加快研究步伐并提供更大的成果。严格性和可重复性，目前还没有研究表明该计划有多成功。拟议的应用研究项目是为了更好地了解 MMRRC 对研究的具体影响。目标#1 提出对 MMRRC 产品如何在整个行业中使用进行高分辨率测量。研究范围以及有关用户的详细信息将表明研究的广度和深度。 MMRRC 支持的研究目标 #2 通过提出问题来衡量 MMRRC 的影响。比如“MMRRC用户是否更有效的科学家？”这样的问题可以通过比较来回答 MMRRC 产品和用户到非 MMRRC 产品和非用户的目标#3 建议开展研究。指纹有助于在缺乏唯一性的情况下唯一地识别研究产品和作者 RRID 和 ORCID iD 提供的标识符这将使我们能够研究 MMRRC 研究的历史。指纹对于按兴趣对研究人员进行聚类也很有用，这将使我们能够主动提出建议向具有共同研究兴趣的科学家提供小鼠模型。