ICSC Core - Informatics

ICSC 核心 - 信息学

• 批准号: 10663909
• 负责人: IAN F KORF
• 金额: $ 26.39万
• 依托单位: UNIVERSITY OF CALIFORNIA AT DAVIS
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-07-01 至 2026-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10663909
• 关键词: Adherence; Agreement; Alleles; Aloral; Applied Research; Archives; Bioinformatics; Biological; Catalogs; Communication; Communities; Data; Database Management Systems; Databases; Development; Electronics; Etiology; Genes; Genetic; Goals; Health; Individual; Industry Standard; Informatics; Information Technology; Internet; Intervention; Legal; Licensing; Maintenance; Marketing; Metric System; Mutant Strains Mice; Nomenclature; Performance; Phenotype; Policies; Price; Process; Protocols documentation; PubMed; Publications; Reporting; Research; Research Personnel; Research Project Grants; Resources; Risk; Secure; Security; Services; Site; Structure; System; United States National Institutes of Health; Update; Vertebral column; Visualization; Work; Writing; application programming interface; base; central database; data access; data acquisition; data curation; data exchange; data quality; design; digital; human disease; informatics tool; material transfer agreement; meetings; member; outreach; programs; relational database; repository; response; statistics; success; tool; web app; web interface; web services; web site

PROJECT SUMMARY – CORE/INFORMATICS The ICSC Informatics Core is the information technology backbone of the NIH Mutant Mouse Resource and Research Centers (MMRRC). As such, the Informatics Core maintains the MMRRC website and databases, it provides all communication services, generates metrics, and it optimizes the MMRRC marketing effort through targeted analyses. This is accomplished with the following IT solutions: [1] a secure MySQL relational database that centralizes all information pertaining to archive holdings, customer accounts, acquisition/order processing, and service requests; [2] an electronic archive of MMRRC documents to secure organizational process assets (SOPs, policies), reports & summaries (meeting minutes, metric reports), and legal agreements (COUs, MTAs); [3] an expert-curated catalog of MMRRC holdings with deep-annotated information on gene(s), allele(s), genetic background, nomenclature, unique identifiers, phenotype, publications, licensing information, husbandry, health, as well as availability & pricing in convenient strain data sheets; [4] data tracking and process refinement to log all information on any one record while simplifying data curation and removing risks to data quality; [5] MMRRC metrics systems that interactively visualizes MMRRC performance in terms of holdings, orders, user access, traffic, and outreach campaign responses; and [6] internal and external data exchanges to enable efficient information sharing between the four MMRRC Centers as well as networking with remote authoritative databases (e.g., PubMed, RRID, MGI, IMSR, Monarch, OMIMM, etc.). The Informatics, furthermore, provides all programming and information technology for the ICSC Applied Research Project. The Informatics Core, hence, takes responsibility for all IT-related development, implementation, expansion, and maintenance of the MMRRC as a resource for the research community under strict adherence to standard industry practices to enhance data stability & security. The success of the Informatics Core efforts is backed by statistics: since 2015, the MMRRC enjoys formidable increases in its user base (~50%) and holdings (~100%) following streamlined donation/order processing with a focus on user-friendliness. In summary, the Informatics Core permits the operational excellence the research community has come to expect from the MMRRC as a bioresearch community resource for translational inquiries into human disease etiology and intervention.

项目摘要 – 核心/信息学 ICSC 信息学核心是 NIH 突变小鼠资源和 研究中心 (MMRRC) 因此，信息学核心维护 MMRRC 网站和数据库。 提供所有通信服务、生成指标，并通过以下方式优化 MMRRC 营销工作： 这是通过以下 IT 解决方案完成的：[1] 安全的 MySQL 关系数据库。 集中与档案馆藏、客户帐户、采购/订单处理有关的所有信息， 和服务请求；[2] MMRRC 文件的电子档案，以确保组织流程资产的安全 （SOP、政策）、报告和摘要（会议纪要、指标报告）以及法律协议（COU、MTA）； [3] 专家整理的 MMRRC 馆藏目录，其中包含有关基因、等位基因、遗传的深入注释信息 背景、命名法、唯一标识符、表型、出版物、许可信息、畜牧业、健康、 [4] 数据跟踪和流程细化以记录 [5] MMRRC 包含任何一项记录上的所有信息，同时简化数据管理并消除数据质量风险； 指标系统，以交互方式可视化 MMRRC 在持仓、订单、用户访问方面的表现， 流量和外展活动响应；以及 [6] 内部和外部数据交换，以实现高效 四个 MMRRC 中心之间的信息共享以及与远程权威数据库的联网 （例如，PubMed、RRID、MGI、IMSR、Monarch、OMIMM 等）此外，信息学还提供所有内容。 ICSC 应用研究项目的编程和信息技术，因此， 负责 MMRRC 的所有 IT 相关开发、实施、扩展和维护 作为研究界的资源，严格遵守标准行业惯例以增强数据 统计数据表明，信息学核心支持的努力取得了成功：自 2015 年以来，MMRRC 在简化捐赠/订单后，其用户群 (~50%) 和持有量 (~100%) 大幅增加 注重用户友好性的处理总而言之，信息学核心允许操作。 研究界对 MMRRC 作为生物研究界资源的卓越期望 对人类疾病病因学和干预的转化研究。