Clinical Laboratory & Biomarker Core

临床实验室

基本信息

批准号：
10458362
负责人：
Craig Walter Hendrix
金额：
$ 56.07万
依托单位：
JOHNS HOPKINS UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2012
资助国家：
美国
起止时间：
2012-05-02 至 2027-04-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10458362
关键词：
AIDS prevention Acquired Immunodeficiency Syndrome Area Awareness Biological Biological Assay Biological Markers Biological Specimen Banks Biological Testing Cataloging Clinic Clinical Clinical Data Clinical Research Collaborations Consult Consultations Data Data Analyses Development Educational process of instructing Equipment and supply inventories Faculty Freezing Goals Guidelines HIV HIV Infections Immunology Institution International Internet Investigation Knowledge Laboratories Maintenance Measures Mentors Methods Natural History Outcome Study Pathogenesis Performance Pharmacology Practice Management Prevention Publications Quality Control Readiness Research Research Personnel Resources Sampling Science Scientist Service provision Services Specimen Students Testing Tissue Banks Training base biobank data integrity data management design improved innovation metabolomics next generation programs quality assurance repository searchable database service providers virology working group

项目摘要

The overall goals of the JHUCFAR Laboratory core are to provide JHU HIV researchers, especially those new to HIV, with: a) world‐class laboratory expertise to assist in the optimal design of clinical studies where specialized laboratory assays are essential to measuring study outcomes, b) access to appropriate, validated and, where applicable, certified laboratory assays, c) biomarker specimen repository for the storage, cataloguing and testing of biological specimens, including access to the clinical data associated with those specimens, and d) training to match the needs of investigators ranging from understanding how to collaborate with laboratory investigators, incorporate laboratory tests in a clinical study, judge assay quality and readiness for use to actual performance of the assays in one’s own laboratory. The Core will establish mechanisms to enhance research in HIV prevention, treatment, and pathogenesis carried out by both new and established investigators at JHU through improved awareness of and access to the extensive laboratory resources within the institution and by establishing connections outside Johns Hopkins when needed. To this end, the Core will directly provide expert consultation and assay service focused in 4 major scientific areas—virology, immunology, pharmacology, and metabolomics—as well as providing access to both data and biological specimen repositories to advance science. Beyond these laboratories, the Core will establish best data management practices – from clinic to lab to data analysis – and facilitate connections and collaborations with a far broader array of core laboratories within JHU and in other CFARs nationally.

Jhucfar实验室核心的总体目标是为JHU HIV研究人员提供，尤其是那些艾滋病毒的新手，a）世界阶级实验室专业知识，以帮助临床研究的最佳设计如果专门实验室测定对于测量研究结果至关重要，则b）访问适用，经过验证，并在适用的情况下进行认证的实验室测定，c）生物标记标本存储，生物标本的存储，编目和测试的存储库，包括访问与这些标本相关的临床数据以及d）培训以满足研究人员的需求从了解如何与实验室调查人员合作的范围内，成立了实验室在一项临床研究，法官测定质量和准备使用测定的实际性能中的测试中的测试自己的实验室。核心将建立增强艾滋病毒预防研究的机制，治疗以及新的和已成熟的研究人员在JHU进行的发病机理提高了对机构内部广泛的实验室资源的认识和获取在需要时建立约翰·霍普金斯之外的连接。为此，核心将直接提供专家咨询和分析服务集中在4个主要科学领域 - 媒毒，免疫学，药理学和代谢组学 - 以及提供数据和生物标本的访问存储库来推进科学。除了这些实验室之外，核心还将建立最佳数据管理实践 - 从诊所到实验室再到数据分析 - 并促进联系与JHU内部和全国其他CFARS内的核心实验室的合作。