Clinical Core

临床核心

• 批准号: 10458360
• 负责人: RICHARD Douglas MOORE
• 金额: $ 78.38万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-05-02 至 2027-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10458360
• 关键词: Acquired Immunodeficiency Syndrome; Address; Adolescent and Young Adult; Affect; Age; Aging; Area; Award; Baltimore; Clinical; Clinical Investigator; Clinical Research; Clinical Services; Collaborations; Communities; Consent; Data Collection; Databases; Development; Disease; Environment; Epidemic; Faculty; Fostering; Functional disorder; Funding; Generations; Goals; HIV; Hospitals; Human Subject Research; Incubated; Individual; Institution; Institutional Review Boards; Investigation; Link; Longevity; Longitudinal cohort; Manuscripts; Maryland; Mentors; Methodology; Modeling; Monitor; Neuraxis; Neurocognitive; Patients; Pilot Projects; Preparation; Process; Publications; Research; Research Methodology; Research Personnel; Resources; Role; Series; Teacher Professional Development; Training; United States National Institutes of Health; Universities; Work; Youth; base; body system; care delivery; care outcomes; career; co-infection; cohort; comorbidity; data resource; design; disparity reduction; experience; human old age (65+); innovation; interest; meetings; multidisciplinary; next generation; novel; patient oriented; patient population; precision medicine; prevent; protocol development; recruit; substance use; symposium; systems research; translational study; transmission process; working group

The Johns Hopkins University CFAR Clinical Core (CC) is designed to promote the generation, maturation, and implementation of new patient-oriented, clinical and translational investigation, with a focus on key areas for NIH-supported HIV scientific research. Our model is grounded in our premise that new research arises when investigators can discuss clinical challenges and these questions become successful research when incubated in a highly supportive intellectual environment and where ample clinical research resources can be provided. The overarching goal of the CC is to foster new HIV clinical research by providing the environment, the resources, and the critical support necessary for the conduct of HIV-associated clinical and translational studies. Addressing HIV-associated comorbidities and co-infections continues to be a high-priority area in which the CC has bridged a number of scientific and clinical resources at Johns Hopkins. The mix of HIV, aging, and substance use affecting our patients highlights the growing importance of neurocognitive complications in HIV, an area that will have a more distinctive role with an integration of the work of our CNS Dysfunction Scientific Working Group into the CC. The CC has also established the capacity and expertise to support clinical research in areas that support the goals of Ending the HIV Epidemic, including research to prevent HIV transmission through provision of treatment, to promote HIV cure, and to reduce disparities in HIV care delivery and outcomes. Within this framework, our Specific Aims are to: 1) Support new and established investigators in conducting HIV patient-based clinical research. This will be done by providing coordinated access to facilities and established databases, direct assistance in the conduct of research by experienced coordinators, and leveraging the breadth and depth of expertise in organ-system research at Johns Hopkins, 2) Promote interdisciplinary HIV clinical research through coordinated exchanges of research methods and ideas among new and established investigators. This will be done by specifically fostering the exchange of ideas and the development of new research through a weekly HIV clinical research seminar series and other venues, and, 3) Provide mentoring to junior and mid-level faculty to develop the next generation of HIV clinical investigators through each step of the process from protocol development, IRB approval, data collection, analysis and manuscript preparation, and by the linkage of junior investigators to established senior investigators through our seminar series and direct training. All of this is done in collaboration with the other CFAR Cores and SWGs to maximize intellectual input and collaboration across the entire CFAR and scientific community at our institution.

约翰·霍普金斯大学CFAR临床核心（CC）旨在促进这一代人， 成熟和实施新的面向患者，临床和翻译研究， 专注于NIH支持的HIV科学研究的关键领域。我们的模型基于 当调查人员可以讨论临床挑战和 在高度支持的智力中孵化时，这些问题成为成功的研究 环境以及提供充足的临床研究资源的地方。总体目标 CC的是通过提供环境，资源和 进行与HIV相关的临床和翻译研究所必需的关键支持。 解决与艾滋病毒相关的合并症和共同感染仍然是高优先级领域 CC在约翰·霍普金斯（Johns Hopkins）桥接了许多科学和临床资源。混合物 艾滋病毒，衰老和药物使用影响我们的患者 艾滋病毒中的神经认知并发症，该领域将具有更独特的作用 我们中枢神经系统功能障碍科学工作组的工作整合到了CC中。 CC 还建立了支持支持领域的临床研究的能力和专业知识 结束艾滋病毒流行的目标，包括用于防止艾滋病毒传播的研究 提供治疗，促进艾滋病毒治愈以及减少艾滋病毒护理递送的差异和 结果。在此框架内，我们的具体目的是：1）支持新的并建立 研究基于HIV患者的临床研究的研究者。这将通过提供 协调访问设施和已建立的数据库，直接协助进行 经验丰富的协调员的研究，并利用专业知识的广度和深度 约翰·霍普金斯（Johns Hopkins）的器官系统研究，2）促进跨学科HIV临床研究 通过新的和建立的研究方法和思想的协调交流 调查人员。这将通过专门培养思想的交流和 通过每周一次的HIV临床研究研讨会和其他 场地，以及3）为初级和中级教师提供指导，以发展下一代 通过协议开发的过程的每个步骤，艾滋病毒临床研究者 批准，数据收集，分析和手稿准备，并通过初级的联系 调查人员通过我们的研讨会系列和直接培训来建立高级研究人员。 所有这些都是与其他CFAR核心和SWG合作完成的，以最大化知识分子 在我们机构的整个CFAR和科学界的投入和协作。