Quantitative genetics and population genomics of repeated complex trait evolution

重复复杂性状进化的数量遗传学和群体基因组学

• 批准号: 10458041
• 负责人: Carrie Wessinger
• 金额: $ 36.82万
• 依托单位: UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-08-01 至 2026-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10458041
• 关键词: Architecture; Biological; Complex; Data; Development; Elements; Evolution; Genes; Genetic; Genetic Processes; Genetic Variation; Genome; Genomics; Investigation; Maintenance; Modeling; Organism; Penstemon; Phenotype; Plants; Population; Quantitative Genetics; Quantitative Trait Loci; Research; Source; Syndrome; System; Testing; Time; Variant; Work; expectation; flexibility; genetic architecture; genomic data; human disease; novel; preservation; reproductive; theories; trait

PROJECT SUMMARY Complex phenotypes are suites of adaptive traits that contribute to a shared function. An important challenge is understanding how such phenotypes evolve and are maintained in populations. Theory predicts that the evolution of complex traits and their preservation in the face of homogenizing gene flow will depend on the genetic architecture of trait divergence, the types and sources of genetic variation, and the presence of reproductive isolating barriers. However, we lack empirical systems to rigorously test these theoretical expectations. While investigations into the genetic basis of repeated phenotypic evolution in emerging model taxa provide an opportunity whether, and how often, evolution proceeds through similar genetic processes, studies of repeated evolution have often involved comparison of only two or three lineages, and rarely have studied complex traits. My research group will bridge these gaps by investigating evolutionary genetics of floral pollination syndrome, a complex adaptation, in the plant genus Penstemon. In this genus, a novel syndrome phenotype has evolved at least 20 independent times. My group will initiate research directions aimed at systematically quantifying genetic and genomic features governing the evolution and maintenance of complex trait diversity, leveraging the exceptional parallelism in Penstemon. We will examine the genetic and genomic architecture of adaptive divergence using replicate QTL analyses, determine which elements of complex traits display genetic parallelism, assess whether standing variation or gene flow act as a source of genetic variation, and examine how complex trait variation is maintained in recently diverged species using population genomic data. This integrative work will contribute to the development of a general framework for understanding whether, and through what mechanisms, phenotypic evolution is constrained by genetic mechanisms. In other words, such data will illuminate the inherent flexibility and limits of an organism's genome to adapt to novel environmental challenges.

项目摘要 复杂的表型是自适应特征的套件，这些特征有助于共享功能。一个 重要的挑战是了解这种表型如何发展并保持在 人群。理论预测，复杂性状的演变及其在 均质基因流的面部将取决于性状差异的遗传结构，即 遗传变异的类型和来源，以及生殖隔离屏障的存在。 但是，我们缺乏严格测试这些理论期望的经验系统。尽管 研究新兴模型分类单元中反复表型进化的遗传基础的研究 提供一个机会，无论进化是否通过类似的遗传进行 过程，对重复进化的研究通常仅涉及两个或三个的比较 血统，很少研究复杂的特征。我的研究小组将通过 研究花授粉综合征的进化遗传学，一种复杂的适应 植物属Penstemon。在这个属中，一种新型综合征表型至少进化了20 独立时间。我的小组将启动旨在系统量化的研究指示 遗传和基因组特征管理复杂性状的演变和维持 多样性，利用Penstemon中的特殊平行性。我们将检查遗传和 使用重复QTL分析的自适应差异的基因组结构，确定哪个 复杂性状的要素表现出遗传并行性，评估站立变化还是 基因流充当遗传变异的来源，并检查了复杂性状变异的方式 使用种群基因组数据维持在最近分歧的物种中。这项综合工作 将有助于建立一个一般框架，以理解是否以及 通过哪些机制，表型进化受到遗传机制的约束。在其他 单词，这样的数据将阐明生物体基因组的固有灵活性和限制 适应新的环境挑战。