Quantitative genetics and population genomics of repeated complex trait evolution

重复复杂性状进化的数量遗传学和群体基因组学

• 批准号: 10458041
• 负责人: Carrie Wessinger
• 金额: $ 36.82万
• 依托单位: UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-08-01 至 2026-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10458041
• 关键词: Architecture; Biological; Complex; Data; Development; Elements; Evolution; Genes; Genetic; Genetic Processes; Genetic Variation; Genome; Genomics; Investigation; Maintenance; Modeling; Organism; Penstemon; Phenotype; Plants; Population; Quantitative Genetics; Quantitative Trait Loci; Research; Source; Syndrome; System; Testing; Time; Variant; Work; expectation; flexibility; genetic architecture; genomic data; human disease; novel; preservation; reproductive; theories; trait

PROJECT SUMMARY Complex phenotypes are suites of adaptive traits that contribute to a shared function. An important challenge is understanding how such phenotypes evolve and are maintained in populations. Theory predicts that the evolution of complex traits and their preservation in the face of homogenizing gene flow will depend on the genetic architecture of trait divergence, the types and sources of genetic variation, and the presence of reproductive isolating barriers. However, we lack empirical systems to rigorously test these theoretical expectations. While investigations into the genetic basis of repeated phenotypic evolution in emerging model taxa provide an opportunity whether, and how often, evolution proceeds through similar genetic processes, studies of repeated evolution have often involved comparison of only two or three lineages, and rarely have studied complex traits. My research group will bridge these gaps by investigating evolutionary genetics of floral pollination syndrome, a complex adaptation, in the plant genus Penstemon. In this genus, a novel syndrome phenotype has evolved at least 20 independent times. My group will initiate research directions aimed at systematically quantifying genetic and genomic features governing the evolution and maintenance of complex trait diversity, leveraging the exceptional parallelism in Penstemon. We will examine the genetic and genomic architecture of adaptive divergence using replicate QTL analyses, determine which elements of complex traits display genetic parallelism, assess whether standing variation or gene flow act as a source of genetic variation, and examine how complex trait variation is maintained in recently diverged species using population genomic data. This integrative work will contribute to the development of a general framework for understanding whether, and through what mechanisms, phenotypic evolution is constrained by genetic mechanisms. In other words, such data will illuminate the inherent flexibility and limits of an organism's genome to adapt to novel environmental challenges.

项目概要 复杂表型是有助于共享功能的一组适应性特征。一个 重要的挑战是了解这些表型如何进化并在其中维持 人口。理论预测复杂特征的进化及其在环境中的保存 基因流同质化的面貌将取决于性状差异的遗传结构， 遗传变异的类型和来源，以及生殖隔离障碍的存在。 然而，我们缺乏实证系统来严格检验这些理论预期。尽管 研究新兴模式类群重复表型进化的遗传基础 提供了进化是否以及多久通过类似的遗传进行的机会 过程中，重复进化的研究通常只涉及两个或三个的比较 谱系，很少研究复杂的特征。我的研究小组将通过以下方式弥合这些差距 研究花授粉综合症的进化遗传学，这是一种复杂的适应 植物属 Penstemon。在这个属中，一种新的综合征表型已经进化出至少 20 独立时代。我的小组将启动旨在系统量化的研究方向 控制复杂性状进化和维持的遗传和基因组特征 多样性，利用 Penstemon 中卓越的并行性。我们将检查遗传和 使用重复 QTL 分析的适应性分歧的基因组结构，确定哪些 复杂性状的元素显示遗传平行性，评估是否存在持续变异或 基因流作为遗传变异的来源，并检查性状变异的复杂性 使用种群基因组数据在最近分化的物种中进行维护。这部综合性作品 将有助于制定一个总体框架，以了解是否，以及 通过什么机制，表型进化受到遗传机制的限制。在其他方面 换句话说，这些数据将阐明生物体基因组的固有灵活性和局限性 适应新的环境挑战。