PAS GRAS: DE-RISKING METABOLIC, ENVIRONMENTAL AND BEHAVIORAL DETERMINANTS OF OBESITY IN CHILDREN, ADOLESCENTS AND YOUNG ADULTS

PAS GRAS：降低儿童、青少年和年轻人肥胖的代谢、环境和行为决定因素的风险

• 批准号: 10078402
• 金额: $ 49.91万
• 依托单位: KING'S COLLEGE LONDON
• 依托单位国家: 英国
• 项目类别: EU-Funded
• 财政年份: 2023
• 资助国家: 英国
• 起止时间: 2023 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=10078402
• 关键词: PAS; GRAS; DE; RISKING; METABOLIC

PAS GRAS aims to prevent and reverse obesity and associated metabolic complications in four age groups: pre-pubertal children (3-9 yr), adolescents (10-18 yr), young adults (19-25 yr), and adults (25-55). PAS GRAS focuses on four main pillars. 1) Develop a personalized risk assessment tool (RAT): an algorithm that will anticipate obesity priming and development in the critical age groups, and identify risk factors for specific complications in subsequent years that will constitute new outcomes for interventional studies. 2) Develop and implement RAT-based personalized interventions by integrating non-pharmacological lifestyle modifications including Mediterranean Diet components alone or with rational pharmacological targeting metabolic and neuroendocrine mechanisms. 3) Inform and engage effectively target groups on obesity causes, risks and intervention by co-production of creative and interactive digital tools (including a simpler version of the RAT) and personalized diet and physical activity programs. 4) Expand and consolidate the PAS GRAS tailor-made campaign across Europe through developing joint programs for health and food/nutrition literacy and physical activity, with healthcare centres, schools, sports clubs, municipalities, and other relevant actors and public authorities. PAS GRAS outcomes will contribute to a long-term 15% decrease in overweight/obesity prevalence in adults and 30% in children/adolescents in the EU until 2050, contributing to a downstream reduction of obesity-associated complications, pharmaceutical and surgical interventions, and to promote Mediterranean Diet as tool for a more nutritious and sustainable future. PAS GRAS is a unique multi- and interdisciplinary research team from 8 countries, including 12 top-level Universities and Research Institutions. Non-academic partners include a civil organization, one company, one patient organization and one Pan-European research Society.

PAS GRAS 旨在预防和逆转四个年龄组的肥胖及相关代谢并发症：青春期前儿童（3-9 岁）、青少年（10-18 岁）、年轻人（19-25 岁）和成人（25-25 岁）。 55）。 PAS GRAS 重点关注四个主要支柱。 1）开发个性化风险评估工具（RAT）：一种算法，可以预测关键年龄组肥胖的启动和发展，并确定随后几年特定并发症的风险因素，这将构成干预研究的新结果。 2) 通过整合非药物生活方式改变（包括单独的地中海饮食成分或与针对代谢和神经内分泌机制的合理药理学成分）相结合，开发和实施基于 RAT 的个性化干预措施。 3) 通过共同制作创意和交互式数字工具（包括更简单的 RAT 版本）以及个性化饮食和身体活动计划，向目标群体有效通报肥胖原因、风险和干预措施并让其参与其中。 4) 通过与医疗中心、学校、体育俱乐部、市政当局和其他相关行为者和公共当局制定健康和食品/营养知识和体育活动联合计划，在整个欧洲扩大和巩固 PAS GRAS 量身定制的活动。到 2050 年，PAS GRAS 结果将有助于长期将欧盟成人超重/肥胖患病率降低 15%，儿童/青少年超重/肥胖患病率降低 30%，从而有助于下游减少肥胖相关并发症、药物和手术干预以及推广地中海饮食作为实现更营养、更可持续的未来的工具。 PAS GRAS是一支独特的多学科、跨学科研究团队，来自8个国家，包括12所顶级大学和研究机构。非学术合作伙伴包括一个民间组织、一家公司、一个患者组织和一个泛欧研究协会。