Modeling Core

建模核心

基本信息

批准号：
10449992
负责人：
Craig R Miller
金额：
$ 71.55万
依托单位：
UNIVERSITY OF IDAHO
依托单位国家：
美国
项目类别：
财政年份：
2015
资助国家：
美国
起止时间：
2015-03-15 至 2025-06-30
项目状态：
未结题

项目摘要

Many of the outstanding problems in human health are unsolved because they involve complex processes. Despite remarkable advances in technology, the solutions will not be found by data alone. To seek solutions, we built a core centered on modeling. A good model gives insight into how a process works and, more importantly, how the process can be manipulated to promote human health. Modeling can serve as a common language to link disparate research areas; it improves research at every stage, from hypothesis formulation through analysis. Ultimately, modeling creates a positive feedback loop with empirical approaches, deepening scientific exploration and discovery. During Phase I, we established the Modeling Core centered on a group of Core Fellows: postdocs with diverse modeling expertise. Our Core is unique. In contrast to many other centers that focus on a single biomedical problem, we apply modeling to many biomedical problems and, for each of these, can bring multiple types of modeling to bear. Our Core is agile. We can modify our expertise based on the needs of the Center and of the community. Our Core is catalytic. We have shaped interdisciplinary research in tangible ways: providing modeling expertise to empiricists, growing areas of modeling with high impact, and increasing the number of collaborative proposals and publications. Building on this upward trajectory, our overarching goal is to enhance biomedical discovery across the University and the State by integrating modeling into research via three aims. (1) Support individual Research Projects by engaging in integrative modeling. We achieve this by ensuring that each project has significant effort from a Fellow, and through our Core Initiative on machine learning that will benefit the projects directly. (2) Extend the Modeling Core into emerging research directions. The purpose of this aim is to anticipate and respond to the modeling needs of the research community. This will be accomplished by hiring Fellows in new areas of modeling, by giving current Fellows development opportunities, and by establishing two new Core Initiatives, one in machine learning and one in geospatial modeling. (3) Expand the impact of the Modeling Core across the University and State by recruiting more researchers in additional fields. The purpose of this aim is to grow the number of participants to support the long-term sustainability of the Core and the Center. This will be accomplished primarily by embedding Core Fellows in interdisciplinary teams, as well as by offering Modeling Access Grants and training workshops. Completion of these aims will lead to a stronger Core that supports modeling efforts and improves biomedical research in Idaho. This will move us closer to our long-term goal of building a sustainable Center.

许多人类健康中的许多杰出问题尚未解决，因为它们涉及复杂的过程。尽管技术取得了显着的进步，但仅数据就不会找到解决方案。寻求解决方案，我们建立了一个以建模为中心的核心。一个好的模型可以深入了解过程的工作原理以及更多重要的是，如何操纵该过程以促进人类健康。建模可以作为常见链接不同研究领域的语言；从假设制定，它在每个阶段都改善了研究通过分析。最终，建模通过经验方法创造了积极的反馈回路，加深了科学探索和发现。在第一阶段，我们建立了以一组为中心的建模核心核心研究员：具有不同建模专业知识的博士后。我们的核心是独特的。与许多其他中心相反专注于单个生物医学问题，我们将建模应用于许多生物医学问题，以及每个生物医学问题这些可以带来多种类型的建模。我们的核心是敏捷的。我们可以根据中心和社区的需求。我们的核心是催化性的。我们已经形成了跨学科以切实的方式进行研究：向经验家提供建模专业知识，建模的成长领域影响并增加协作提案和出版物的数量。基于此上升轨迹，我们的总体目标是通过通过三个目标将建模整合到研究中。（1）通过参与个人研究项目集成建模。我们通过确保每个项目都有巨大的努力来实现这一目标，并且通过我们对机器学习的核心计划，将直接受益于项目。（2）扩展建模核心进入新兴研究方向。此目的的目的是预测和回应建模研究界的需求。这将通过在新的建模领域雇用研究员，由为当前的研究员开发机会，并建立两个新的核心计划，一个在机器中学习，一个在地理空间建模中。（3）扩大整个大学的建模核心的影响通过在其他领域招募更多研究人员来陈述。此目的的目的是增加参与者支持核心和中心的长期可持续性。这将完成主要是通过将核心研究员嵌入跨学科团队中，以及提供建模访问赠款和培训讲习班。这些目标的完成将导致更强的核心支持建模工作并改善了爱达荷州的生物医学研究。这将使我们更接近建立一个长期目标可持续中心。