The role structural discrimination on depression, sleep, cardiovascular disease, and cognitive decline

结构性歧视对抑郁、睡眠、心血管疾病和认知能力下降的作用

• 批准号: 10447383
• 负责人: Sarah L Szanton
• 金额: $ 5.81万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-09-30 至 2023-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10447383
• 关键词: Address; African American; African American population; Aging; Alzheimer' s Disease; Alzheimer' s disease related dementia; Award; Black race; Cardiovascular Diseases; Cognition; Communities; Data Analyses; Data Set; Development Plans; Discrimination; Education; Elderly; Employment; Environment; Health; Health and Retirement Study; Healthcare; Impaired cognition; Income; K-Series Research Career Programs; Life; Marketing; Measures; Mental Depression; Mentorship; Methods; Neighborhoods; Parents; Paris, France; Police; Publications; Race; Research; Research Personnel; Risk Factors; Role; Sleep; Sleep Deprivation; Structure; Testing; Time; United States; career development; comorbidity; experience; member; parent grant; racial disparity; research and development; resilience

PROJECT SUMMARY This application for a Research Supplement to Promote Diversity in Health-Related Research (PA-21-071) proposes a research and career development plan to develop the independence of Dr. Paris Adkins-Jackson through a study titled, “The role of structural discrimination on depression, sleep, cardiovascular disease, and cognitive decline” for the award period of 10/1/21-9/30/23. The parent grant, “Reducing racial disparities in Alzheimer’s Disease and related dementias: Addressing structural discrimination and resilience” (DP1AG069874). The parent grant is a sequential mixed methods study to develop a measure of structural discrimination and then determine the influence of structural discrimination on cognitive decline in the United States (US). The study draws expertise from Black community members to elucidate how 9 domains of structural discrimination impact the lives of Black older adults. These domains include (1) education, (2) employment, (3) healthcare, (4) environment, (5) neighborhoods, (6) policing, (7) media and marketing, (8) civics, and (9) income, credit, and wealth. The proposed supplement study is a secondary data analysis examining the influence of structural discrimination on known relationships between Alzheimer’s disease (AD)- related cognitive decline and co-morbidities like depression, sleep deprivation, and cardiovascular disease. This study will test the validity of the parent award’s 9-domain measure of structural discrimination in two large aging datasets: National Health and Aging Study (NHATS) and Health and Retirement Study (HRS). Additionally, this study will estimate the influence of the nine domains of structural discrimination on the previously established relationships of AD-cognitive decline with depression, sleep deprivation, and cardiovascular disease. The proposed diversity supplement will significantly contribute to the understanding of the role of structural discrimination on AD racial disparities by delineating the effect of structural discrimination on AD and a few known risk factors and provide mentorship for developing a K award and publication profile in structural discrimination and cognition.

项目概要 本申请旨在促进健康相关研究的多样性（PA-​​21-071） 提出一项研究和职业发展计划，以培养帕丽斯·阿德金斯-杰克逊博士的独立性 通过一项题为“结构性歧视对抑郁、睡眠、心血管疾病和 认知能力下降”，奖励期为 10/1/21-9/30/23。 家长补助金，“减少种族差异”。 “阿尔茨海默病和相关痴呆症：解决结构性歧视和恢复力” (DP1AG069874) 母基金是一项连续混合方法研究，旨在开发结构性衡量标准。 歧视，然后确定结构性歧视对美国认知能力下降的影响 该研究借鉴了黑人社区成员的专业知识，阐明了 9 个领域如何 结构性歧视影响黑人老年人的生活，这些领域包括（1）教育，（2）。 就业、(3) 医疗保健、(4) 环境、(5) 社区、(6) 治安、(7) 媒体和营销、(8) 公民，(9) 收入、信用和财富 拟议的补充研究是二次数据分析。 研究结构歧视对阿尔茨海默病 (AD) 之间已知关系的影响 相关的认知能力下降以及抑郁症、睡眠不足和心血管疾病等并发症。 这项研究将测试家长奖励的结构性歧视的 9 个领域衡量标准在两个大学校中的有效性。 老龄化数据集：国家健康与老龄化研究（NHATS）和健康与退休研究（HRS）。 此外，本研究将估计结构性歧视的九个领域对 先前已确定 AD 认知能力下降与抑郁、睡眠不足和 拟议的多样性补充将极大地促进对心血管疾病的理解。 通过描述结构性歧视的影响来探讨结构性歧视对 AD 种族差异的作用 AD 和一些已知的风险因素，并为制定 K 奖和出版物简介提供指导 结构性歧视和认知。

项目成果

Methodological approaches for studying structural racism and its biopsychosocial impact on health.

研究结构性种族主义及其对健康的生物心理社会影响的方法论。

• DOI: 10.1016/j.outlook.2022.07.008
• 发表时间: 2022
• 期刊: Nursing outlook
• 影响因子: 4.3
• 作者: Adkins-Jackson,ParisB;IncollingoRodriguez,AngelaC
• 通讯作者: IncollingoRodriguez,AngelaC

Association of Perceived Neighborhood Environments With Cognitive Function in Older Adults.

感知的邻里环境与老年人认知功能的关联。

• DOI: 10.3928/00989134-20230707-04
• 发表时间: 2023
• 期刊: Journal of gerontological nursing
• 影响因子: 1.3
• 作者: Kim,Boeun;Rosenberg,DoriE;Dobra,Adrian;Barrington,WendyE;Hurvitz,PhilipM;Belza,Basia
• 通讯作者: Belza,Basia

Structural Racial Discrimination and Structural Resilience: Measurement Precedes Change.

• DOI: 10.1093/gerona/glab344
• 发表时间: 2022-02-03
• 期刊: The journals of gerontology. Series A, Biological sciences and medical sciences
• 作者: Szanton SL;LaFave SE;Thorpe RJ
• 通讯作者: Thorpe RJ