High-end MALDI Time of Flight Mass Spectrometer for Bioanalysis

用于生物分析的高端 MALDI 飞行时间质谱仪

• 批准号: 10440788
• 负责人: Alexandra Ros
• 金额: $ 60万
• 依托单位: ARIZONA STATE UNIVERSITY-TEMPE CAMPUS
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-08-15 至 2023-08-14
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10440788
• 关键词: Area; Arizona; Biological; Biotechnology; COVID-19 test; Communities; Core Facility; Disease; Environment; Faculty; Funding; Future Generations; Image; Institutes; Institution; Malignant Neoplasms; Mass Spectrum Analysis; Medical; Metabolism; Molecular; Neurodegenerative Disorders; Photosynthesis; Process; Research; Research Personnel; Research Project Grants; Resolution; Saliva; Schools; Science; Services; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Structure; Students; Talents; Time; United States National Institutes of Health; Universities; base; flexibility; innovation; instrument; invention; mass spectrometer; member; news; next generation; pandemic disease; tool

PROJECT SUMMARY Mass spectrometry (MS) is an essential tool to support biologically and biomedically related research at Arizona State University (ASU). In 2018, ASU has centralized its mass spectrometry services in a core facility that serves over 100 researchers throughout ASU and surrounding academic and biotechnology entities. ASU is proud of having been recognized as #1 in innovation for the 6th time in a row by US News, but to hold this status and serve the needs for the ASU research community and its students, core and support facilities need to meet the requirements of the next generation cutting-edge research environment. The MS Core Facility at ASU is centrally located in the Biodesign Institute, a forerunner of biological and medical invention focusing on societal problems such as for example a saliva based COVID-19 test that was made available to the Arizona public during the ongoing pandemic. ASU and the Biodesign Institute also thrive as a top research institution for biomolecular structure elucidation to unlock key biomolecular details responsible for biological and medical processes involved in metabolism and diseases such as cancer and neurodegenerative disorders. Researchers at ASU also strive in gaining biomolecular signatures important to understand energy conversion and photosynthesis to solve our and future generation’s energy needs. In addition, the School of Molecular Sciences at ASU has among its faculty members talented young and established researchers that take molecular sciences to the next level with innovative synthesis approaches. All these areas require reliable and flexibly accessible structure elucidation tools, which in many cases is accomplished or supplemented through matrix assisted laser desorption ionization (MALDI) MS. However, the MS core facility at ASU only owns one rather basic MALDI MS instrument, which we intend to supplement through the current proposal with a more sensitive and higher resolution instrument also capable of MALDI imaging. With this new MALDI MS instrument we will upgrade the available MS analysis capabilities at ASU to meet the needs of our currently funded NIH researchers but also provide a tool paving the way for the next generation of research projects facilitated through high end mass spectrometry.

项目摘要 质谱法（MS）是一种在亚利桑那州支持生物学和生物医学研究的ES科学工具 州立大学（ASU）。 在ASU ASU ASU ASU ASUPOMIC和BIOTECHNOLOGY中，超过100多个研究。 我们被美国新闻连续被认为是创新的第一名，但要保持这种状态和 满足ASU研究社区的需求，是学生，核心和支持设施需要满足您的需求 下一代尖端研究环境的要求。 位于生物和医学的先驱生物设计学院。 例如，例如基于唾液的Covid-19测试 正在进行的大流行。 结构阐明以解锁负责生物学和医学过程的关键生物分子细节 在癌症和神经退行性疾病等新陈代谢和疾病中。 在获得理解能量转换和光合作用的生物分子征收时，以解决我们 以及未来的能量需求。 教职员工将年轻和成熟的研究人员带入了将分子科学提升到一个新的水平。 创新的综合方法。 在许多卡斯中，工具是录制或支撑矩阵的辅助laspution laspution电离电离。 （MALDI）然而，ASU拥有所有拥有人拥有的MS核心机构拥有所有权Owns Owns Owns Owns Owns Owns Owns Owns Owns Owns Owns Owns Owns Owns Owns Owns iross Is Owns 打算通过当前的提案补充更敏感和更高的分辨率仪器 能够使用新的MALDI MS仪器进行MALDI成像 ASU的能力满足我们目前资助的NIH研究人员的需求，但也提供了铺平它们的工具 下一代研究项目通过高端质谱促进的方式。