UCSD Biomedical Scientist Career Development Program in Glycoscience

加州大学圣地亚哥分校糖科学生物医学科学家职业发展计划

基本信息

批准号：
10439513
负责人：
Jeffrey D Esko
金额：
$ 105.05万
依托单位：
UNIVERSITY OF CALIFORNIA, SAN DIEGO
依托单位国家：
美国
项目类别：
财政年份：
2018
资助国家：
美国
起止时间：
2018-07-01 至 2024-06-30
项目状态：
已结题

项目摘要

PROJECT SUMMARY UCSD Biomedical Scientist Career Development Program in Glycoscience. Glycans are a vital part of all biological systems and are involved in all disease processes, but progress in understanding these key components of life has lagged far behind that of other macromolecules. Consonant with the 2012 National Research Council report “Transforming Glycoscience: A Roadmap for the Future”, efforts such as the Consortium for Functional Glycomics and the NIH Director’s Common Fund Glycoscience Initiative have sought to correct some of the technical problems, such as deficiencies in glycan synthesis, lack of tools for probing and analyzing glycans, and glycobioinformatics. The NHLBI Programs of Excellence in Glycosciences began to fill another deficiency—the lack of young investigators fluent in the concepts of glycan chemistry and biology and skilled in working with glycans. Meanwhile, the NHLBI convened a Working Group to consider mechanisms to address the still unmet need for training young scientists and physician-scientists in glycoscience, which led to this K12 Request for Applications. The leadership and faculty of the University of California (UCSD) Glycobiology Research and Training Center have played key roles in many of the above national efforts, while locally establishing coursework, the 3rd edition of Essentials of Glycobiology, core facilities and symposia that have already contributed toward excellent training in glycoscience. With 18+ years of experience, the Glycobiology Research and Training Center is uniquely positioned to respond to this request for applications with a career development program that will train a new generation of biomedical researchers versed in glycoscience. Recent graduates with MD, PhD or MD/PhD degrees will be recruited from local physician-scientist and PhD-granting programs and via national advertising to train for 2-3 years under established investigators in biomedical, biological and chemical sciences, who have a strong knowledge base regarding glycans. Run by three PIs with expertise in each of these fields, the Program will provide structured didactic and hands-on training in glycoscience through research projects relevant to the NHLBI mission. Nineteen outstanding scientists with interest in glycoscience will serve as mentors. Trainees will be exposed to currently available state-of-the-art technologies in glycan research through the GlycoAnalytics Core at UCSD, by rotation through other Consortium sites, or through short courses offered at other institutions. The UCSD Program will promote trainee diversity by active participation in national outreach programs and the existing UCSD IRACDA program. Regular networking with Visiting Professors/Advisors and participation in local, national and international symposia will round out their training. The UCSD Program will train as many 18 Scholars over the next 5 years, launching their careers as independent investigators who see glycans as integral components of their expertise, and central to their own scientific discoveries.

项目摘要 UCSD生物医学科学家职业发展计划。聚糖是所有人的重要组成部分生物系统并参与了所有疾病过程，但是在理解这些关键方面的进展生命的组成部分远远落后于其他大分子。与2012年国家的辅音研究委员会报告“转变糖科学：未来的路线图”，例如功能性糖基质的财团和NIH董事的共同基金GlyCosciencientive已有试图纠正某些技术问题，例如聚糖合成中的缺陷，缺乏工具探测和分析聚糖和糖菌信息学。 NHLBI糖基卓越卓越计划开始填补另一种缺乏症 - 缺乏年轻的调查人员能够流利的聚糖化学概念和生物学和擅长与聚糖合作。同时，NHLBI召集了一个工作组来考虑解决对培训年轻科学家和身体科学家的需求仍然未满足的机制 GlyCoscience，这导致了此K12请求申请。大学的领导和教职员工加利福尼亚（UCSD）Glycobiology研究和培训中心在上述许多中都发挥了关键作用国家努力虽然在本地建立课程工作，但第三版是糖生物学的基本要素，核心已经有助于糖科学培训的设施和座谈会。有18年以上在经验中，糖生物学研究和培训中心是唯一地响应这一请求的用于通过职业发展计划的应用程序，该计划将培训新一代生物医学研究人员精通糖科学。将从本地招募MD，PhD或MD/PhD学位的近期毕业生身体科学家和博士学位授予计划，并通过国家广告培训2 - 3年具有强大知识库的生物医学，生物学和化学科学领域的既定研究者关于聚糖。由三个PI在这些领域中具有专业知识的三个PI运行，该程序将提供结构化的通过与NHLBI任务相关的研究项目，在Glycoscience进行教学和动手培训。对糖科感兴趣的十九位杰出科学家将担任导师。学员将接触到目前，通过UCSD的甘氨酸核心核心核心研究中可用的最先进技术，通过旋转其他财团或通过其他机构提供的短期课程。 UCSD 计划将通过积极参与国家外展计划和现有 UCSD IRACDA计划。与访问教授/顾问的定期网络，并参与本地国家和国际座谈会将彻底完成他们的培训。 UCSD计划将培训多18 在接下来的五年中，学者们以独立调查员的身份开始了他们的职业其专业知识的组成部分，以及他们自己的科学发现的核心。

项目成果

期刊论文数量（6）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Preparing glycomics data for robust statistical analysis with GlyCompareCT.

DOI：
10.1016/j.xpro.2023.102162
发表时间：
2023-03-13
期刊：
STAR PROTOCOLS
影响因子：
0
作者：
Zhang, Yujie;Krishnan, Sridevi;Bao, Bokan;Chiang, Austin W. T.;Sorrentino, James T.;Schinn, Song-Min;Kellman, Benjamin P.;Lewis, Nathan E.
通讯作者：
Lewis, Nathan E.

Bicarbonate Effects on Antibacterial Immunity and Mucus Glycobiology in the Cystic Fibrosis Lung: A Review With Selected Experimental Observations.

碳酸氢盐对囊性纤维化肺抗菌免疫和粘液糖生物学的影响：选择性实验观察的回顾。