UC Davis Multi-Disciplinary Cancer Research Training Program to Advance Precision Cancer Prevention and Care in Latin America.

加州大学戴维斯分校多学科癌症研究培训计划，以推进拉丁美洲的精准癌症预防和护理。

• 批准号: 10438437
• 负责人: Luis Guillermo Carvajal Carmona
• 金额: $ 27万
• 依托单位: UNIVERSITY OF CALIFORNIA AT DAVIS
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-01 至 2027-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10438437
• 关键词: Address; Age; American; Area; Basic Science; Bioinformatics; Cancer Burden; Cancer Center; Cancer Control; Cessation of life; Clinical; Clinical Oncology; Collaborations; Colombia; Colombian; Complement; Country; Demography; Development; Educational Curriculum; Ethics; European; Foundations; Funding; Funding Opportunities; Goals; Healthcare; Home; Individual; Infection Control; Institution; Knowledge; Latin America; Latin American; Latino Population; Lead; Life Expectancy; Malignant Neoplasms; Mentors; Mutation; National Cancer Institute; Oncology; Patients; Peru; Peruvian; Physicians; Population; Precision therapeutics; Principal Investigator; Provider; Reporting; Research; Research Personnel; Research Project Grants; Research Support; Resource Development; Resources; Risk Assessment; Solid; Training; Training Programs; United States National Institutes of Health; Universities; anticancer research; base; biobank; cancer care; cancer epidemiology; cancer genetics; cancer risk; cancer therapy; cloud based; experience; graduate student; health care availability; human capital; individualized prevention; low and middle-income countries; multidisciplinary; pre-clinical; precision cancer prevention; precision oncology; programs; skills; tool

PROJECT SUMMARY Improvements in health care access and infection control have led to life expectancy increases in Low- and Middle-Income Countries (LMICs) in Latin America. As the population ages, the Latin American cancer burden has dramatically increased. By 2030, Latin America is expected to have annual averages of 1.6M new cancer cases and 1M cancer deaths. A Latin America Lancet Oncology Commission report highlighted the small amount of preclinical and clinical oncology research originating in the region as a limitation to control cancer burden. Colombia and Peru, the Latin American LMICs with the first and second largest populations, have state-funded national cancer institutes (NCIs) that are cancer treatment reference centers, and which lead national efforts in cancer control and care. However, cancer risk assessment and patient treatment at these institutions is primarily based on tools developed in North American and European patients. Despite having exceptional researchers and physicians, most cancer centers in Latin America lack training programs that would allow them to develop or adapt precision prevention or treatment tools that are appropriate to the ancestry or mutation profiles of individuals from the region. The current funding opportunity is the ideal program to formalize and enhance ongoing collaborations between US-based healthcare researchers and providers in Colombia and Peru. It will provide a solid foundation for precision oncology research knowledge transfer and to build local human capital necessary to develop precision cancer medicine in Latin America. Building on our extensive expertise on Latin American population demography, cancer epidemiology and genetics, NIH funded cancer studies in Latino populations, and a strong track record of research collaboration and training with Colombian and Peruvian researchers, the overall goals of the UC Davis Multidisciplinary Cancer Research Training Program to Advance Precision Cancer Prevention and Care in Latin America are to: 1) Enhance local capacity for precision cancer medicine research in Colombia and Peru by implementing a curriculum that complements and addresses gaps in local training programs and provides hands on experience and support for research project development relevant to the region, 2) Provide hands on training on research resource development including ethics training, biobanking best practices, and cloud-based bioinformatics; and 3) allocate pilot funding for mentored research for basic science and clinically-oriented term trainees. We propose to establish a curriculum to train graduate students and postdoctoral/clinical fellows in precision oncology research. We will prepare trainees to implement and share their new skills in their home countries and to collaborate with U.S-based investigators. We will leverage ongoing collaborations among the program Principal Investigators, universities, and NCIs of Colombia and Peru to identify relevant areas of research that could be enhanced by the training program.

项目摘要 医疗保健获取和感染控制的改善已导致低和低的预期寿命增加 拉丁美洲的中等收入国家（LMIC）。随着人口的年龄，拉丁美洲癌症负担 大大增加了。到2030年，拉丁美洲预计将有160万个新癌症的年平均值 病例和1M癌症死亡。拉丁美洲柳叶刀肿瘤学委员会报告强调了小规模 源自该地区的临床前和临床肿瘤学研究的数量是控制癌症的限制 负担。哥伦比亚和秘鲁是第一和第二大人口的拉丁美洲LMIC， 由国家资助的国家癌症研究所（NCIS）是癌症治疗参考中心，并且领导 国家控制和护理方面的努力。但是，癌症风险评估和患者治疗 机构主要基于北美和欧洲患者开发的工具。尽管有 杰出的研究人员和医生，拉丁美洲的大多数癌症中心都缺乏培训计划 将使他们能够开发或适应适合于 该地区个体的祖先或突变特征。当前的资金机会是理想的 计划正式和增强总部位于美国医疗保健研究人员与 哥伦比亚和秘鲁的提供者。它将为精确肿瘤研究知识提供坚实的基础 转移并建立在拉丁美洲开发精确癌症医学所必需的当地人力资本。 以我们在拉丁美洲人口人口统计学，癌症流行病学和 遗传学，NIH资助了拉丁裔人口的癌症研究，并有很强的研究合作记录 以及哥伦比亚和秘鲁研究人员的培训，加州大学戴维斯分校多学科的总体目标 癌症研究培训计划，以提高拉丁美洲的精确癌症预防和护理的计划： 1）通过实施哥伦比亚和秘鲁的精确癌症医学研究的局部能力 课程补充并解决本地培训计划中的差距，并提供经验 并支持与该地区相关的研究项目发展，2）提供研究培训 资源开发，包括道德培训，生物库最佳实践和基于云的生物信息学；和 3）为基础科学和临床学期学员的指导研究分配试点资金。我们 建议建立一门课程，以精确培训研究生和博士后/临床研究员 肿瘤学研究。我们将准备学员在自己的祖国实施和分享他们的新技能 并与美国的调查员合作。我们将利用该计划之间正在进行的合作 哥伦比亚和秘鲁的主要研究人员，大学和NCI，以确定相关研究领域 培训计划可以增强。