CP-STAR - Tethered catylysts: Step-change high purity manufacture of high value pharmaceutical fine chemical and biotechnology products

CP-STAR - 系留催化剂：高价值医药精细化工和生物技术产品的逐步高纯度制造

• 批准号: 100734
• 金额: $ 91.59万
• 依托单位: YORKSHIRE PROCESS TECHNOLOGY LIMITED
• 依托单位国家: 英国
• 项目类别: Collaborative R&D
• 财政年份: 2009
• 资助国家: 英国
• 起止时间: 2009 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=100734
• 关键词: CP; STAR; Tethered; catylysts; Step

This industry-led project will enable new approaches to process chemistry based on advances in synthetic methods. The project investigates 'tethering' of new catalyst ligands to solid supports (such as polymer beads or porous surfaces) to prevent catalyst and reagent residues ending up in products and allow re-use and recycling. This also enables new, intensive flow manufacturing processes to be investigated. Over 3 years the project aims to take the background science through to the point of real application trials in high value manufacturing processes. The expected benefits to the chemicals, pharmaceutical and biotech sectors are: 1) compliance with regulatory metal contamination limits in drug manufacture without expensive purification processes and reducing need for plant cleaning; 2) enabling use of novel catalysts, including chemistry to avoid alkylating reagents in pharma synthesis; 3) enabling re-use of catalysts, reducing catalyst and solvent consumption, reducing use of limited specialist metal resources; 4) designing 'scaleability' and ‘recyclability’ into new catalyst systems for application in commercial processes, supporting resource and process intensification.

这个行业主导的项目将基于合成方法的进步，研究新催化剂配体与固体载体（例如聚合物珠或多孔表面）的“束缚”，以防止催化剂和试剂残留。该项目的目标是在三年内将背景科学带到高价值制造工艺的实际应用试验阶段。化学品、制药和生物技术领域包括：1) 无需昂贵的纯化过程即可遵守药物制造中的金属污染限制，并减少工厂清洁的需要；2) 能够使用新型催化剂，包括避免在药物合成中使用烷基化试剂的化学方法；3) 能够重复使用催化剂； ，减少催化剂和溶剂消耗，减少对有限专业金属资源的使用；4）将“可扩展性”和“可回收性”设计成新的催化剂系统，用于商业过程，支持资源和过程强化。