BMI Bioinformatics Training Grant

BMI 生物信息学培训补助金

• 批准号: 10430103
• 负责人: Ryan D. Hernandez
• 金额: $ 62.44万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-07-01 至 2023-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10430103
• 关键词: Bioinformatics; Body mass index; Grant; Training

ABSTRACT The UCSF Graduate Program in Bioinformatics is seeking continuation of its training program in Bioinformatics and Computational Biology. The program focuses on training young scientists who will serve as leaders in re- search at the interface between computation and biology. The training plan for coursework, enrichment activi- ties, and research reflects the fundamentally collaborative culture at UCSF. Thus, both the formal and informal features of the program have been designed to bring together students from different disciplines and train them for team-based problem solving. Although the focus is on computational research, all students are exposed to experimental biology in many aspects of their training including research rotations and research-based coursework. As a result, our graduates understand the sources of their data as well as how to manipulate it and are prepared to interact in multidisciplinary teams that require an understanding of both "wet" and "dry" scientific cultures. Our program has dramatically expanded our outreach efforts to recruit a diverse and talent- ed group of students with computational and quantitative backgrounds, and have developed initiatives to foster a healthy community of inclusion and respect for students across all races, religions, countries of origin, sexual orientations, genders, and ethnicities. We stand with all students, and train them to tackle challenging prob- lems in biology at scales that span the molecular to the phenotypic. The hallmarks of our program include: ● Collaborative and inter-disciplinary research. Training faculty are heavily involved in collaborative research, both within and outside of UCSF. Many of their labs (and trainees) are involved in Consortia or Centers created to address problems that cannot be solved from a single viewpoint but require contributions from many disciplines. Student publications reflect this culture. ● An innovative and evolving curriculum. Our core values of collaboration and interdisciplinary research are instilled from day one in “Bootcamp”, and continue in well-tested and new intensive project-based core courses designed to establish a common knowledge and language, and to foster team skills. A modular panel of “selectives” addresses important knowledge gaps in statistics and computer/data science, inherent in the diverse scientific backgrounds of our students. Current and new `mini courses' facilitate deep explo- ration of research topics in small groups with faculty experts, and allow the curriculum to adjust to current scientific developments, and in response to student and alumni feedback and program assessment. ● Intensive training in communication, and preparation for diverse careers. We emphasize training in key competencies needed in diverse careers in academia, industry, or the public sector, including oral and writ- ten presentation, communication, and teamwork skills. Students can participate in career preparation work- shops and internships, and many take on leadership roles in outreach and teaching. Our alumni include leaders in both academia and industry, including several who have started successful companies.

抽象的 加州大学旧金山分校生物信息学研究生项目正在寻求继续其生物信息学培训项目 该计划的重点是培训年轻科学家，他们将成为研究领域的领导者。 搜索计算和生物学之间的界面。课程作业、强化活动的培训计划。 因此，无论是正式还是非正式的合作文化，研究都反映了加州大学旧金山分校的根本合作文化。 该计划的特点旨在将来自不同学科的学生聚集在一起并对他们进行培训 尽管重点是计算研究，但所有学生都会接触到基于团队的问题解决。 实验生物学在其培训的许多方面，包括研究轮换和基于研究的 因此，我们的毕业生了解数据的来源以及如何操纵数据。 并准备好在需要了解“湿”和“干”的多学科团队中进行互动 我们的计划极大地扩大了我们的外展工作，以招募多元化的人才—— 教育组由具有计算和定量背景的学生组成，并制定了促进 一个健康的社区，包容和尊重所有种族、宗教、原籍国、性取向的学生 我们与所有学生站在一起，并培训他们解决具有挑战性的问题。 从分子到表型的生物学领域我们项目的特点包括： ● 合作和跨学科研究 培训教师积极参与合作研究、 加州大学旧金山分校内外的许多实验室（和实习生）都参与了联盟或中心。 创建的目的是为了解决从单一观点无法解决但需要各方贡献的问题 许多学科的出版物都反映了这种文化。 ● 创新和不断发展的课程是我们合作和跨学科研究的核心价值观。 从“Bootcamp”的第一天开始灌输，并继续经过充分测试和新的基于项目的强化核心 课程旨在建立共同的知识和语言，并培养团队技能。 “选择性”小组解决了统计和计算机/数据科学中固有的重要知识差距 当前和新的“迷你课程”有助于深入探索我们学生的不同科学背景。 与教师专家一起以小组形式分配研究课题，并允许课程根据当前情况进行调整 科学发展，并回应学生和校友的反馈和项目评估。 ● 强化沟通培训，为多元化职业做好准备 我们强调关键培训。 学术界、工业界或公共部门的各种职业所需的能力，包括口头和书面能力 学生可以参与十项演讲、沟通和团队合作技能的职业准备工作—— 商店和实习，许多人在外展和教学中担任领导角色。 学术界和工业界的领导者，其中包括一些已经创办了成功公司的人。

项目成果

CRISPR/Cas9-mediated PD-1 disruption enhances anti-tumor efficacy of human chimeric antigen receptor T cells.

• DOI: 10.1038/s41598-017-00462-8
• 发表时间: 2017-04-07
• 期刊: Scientific reports
• 影响因子: 4.6
• 作者: Rupp LJ;Schumann K;Roybal KT;Gate RE;Ye CJ;Lim WA;Marson A
• 通讯作者: Marson A

Many human accelerated regions are developmental enhancers.

• DOI: 10.1098/rstb.2013.0025
• 发表时间: 2013-12-19
• 期刊: Philosophical transactions of the Royal Society of London. Series B, Biological sciences
• 作者: Capra JA;Erwin GD;McKinsey G;Rubenstein JL;Pollard KS
• 通讯作者: Pollard KS

Genome-wide association study identifies ABCG2 (BCRP) as an allopurinol transporter and a determinant of drug response.

• DOI: 10.1002/cpt.89
• 发表时间: 2015-05
• 期刊: CLINICAL PHARMACOLOGY & THERAPEUTICS
• 影响因子: 6.7
• 作者: Wen, C. C.;Yee, S. W.;Liang, X.;Hoffmann, T. J.;Kvale, M. N.;Banda, Y.;Jorgenson, E.;Schaefer, C.;Risch, N.;Giacomini, K. M.
• 通讯作者: Giacomini, K. M.

Target-switch SELEX: Screening with alternating targets to generate aptamers to conserved terminal dipeptides.

• DOI: 10.1016/j.xpro.2022.101724
• 发表时间: 2022-12-16
• 期刊: STAR PROTOCOLS
• 作者: Cutts, Zachary William;Hong, Jessica M.;Shao, Shirley;Tran, Alexander;Dimon, Michelle;Berndl, Marc;Wu, Diana;Pawlosky, Annalisa
• 通讯作者: Pawlosky, Annalisa

Ultraconservation of enhancers is not ultranecessary.

增强子的过度保守并不是绝对必要的。

• DOI: 10.1038/s41588-021-00839-6
• 发表时间: 2021
• 期刊: Nature genetics
• 影响因子: 30.8
• 作者: Pittman,Maureen;Pollard,KatherineS
• 通讯作者: Pollard,KatherineS