08 Oncologic Imaging Program

08 肿瘤影像项目

基本信息

批准号：
10430017
负责人：
TIMOTHY J EBERLEIN
金额：
$ 6.72万
依托单位：
WASHINGTON UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2001
资助国家：
美国
起止时间：
2001-08-02 至 2025-06-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10430017
关键词：
Academia Address Animal Model Animals Area Artificial Intelligence Automobile Driving Award Basic Cancer Research Basic Science Binding Biological Cancer Biology Cancer Center Cancer Center Support Grant Clinic Clinical Collaborations Data Data Analytics Detection Development Diagnosis Diagnostic Procedure Educational workshop Engineering Environment Event Extramural Activities Faculty Financial Support Fostering Funding Funding Opportunities Goals Grant Human Hybrids Image Image-Guided Surgery Imaging Device Imaging technology Industry Informatics Information Retrieval Investments Knowledge Lasers Leadership Magnetic Resonance Imaging Malignant Neoplasms Mentors Methodology Methods Molecular Monitor Multimodal Imaging Multiple Myeloma NMR Spectroscopy Nature Optics PET/CT scan Patient-Focused Outcomes Patients Peer Review Pilot Projects Positron-Emission Tomography Prediction of Response to Therapy Process Property Publications Radioisotopes Recording of previous events Research Research Activity Research Infrastructure Research Personnel Resolution Resource Sharing Resources Scholarship Schools Science Signal Transduction Students System Teacher Professional Development Testing Therapeutic Training Translating Translational Research Translations Treatment Protocols Treatment outcome United States National Institutes of Health Vision base behavioral phenotyping cancer diagnosis cancer imaging cancer therapy chemotherapy clinical decision-making clinical translation data mining deep learning detector fluorescence molecular tomography image guided imaging agent imaging biomarker imaging facilities imaging informatics imaging modality imaging probe imaging program imaging system improved in vivo Cellular and Molecular Imaging Centers industry partner innovation insight instrument instrumentation lectures machine learning algorithm member microPET molecular imaging multidisciplinary nanotherapy next generation novel optoacoustic tomography patient response photoacoustic imaging physical science pre-clinical programs proton beam quantitative imaging radiation response radiomics response skills student mentoring student training targeted treatment theranostics tool translational pipeline treatment response tumor tumor progression ultrasound

项目摘要

ONCOLOGIC IMAGING PROGRAM (OIP): PROJECT SUMMARY The Oncologic Imaging Program (OIP) develops novel imaging agents and innovative methods for radionuclide, MR, ultrasound, optical, and hybrid imaging technologies, including photoacoustic imaging and theranostics. Application of artificial intelligence and informatics platforms to solve advanced oncologic imaging challenges demonstrates the evolving nature of OIP. OIP’s major goals are to facilitate new research initiatives, expand ongoing collaborations, mentor junior faculty, train students and fellows, and develop new methods to solve fundamental and clinical cancer imaging needs. These goals will be achieved through intra- and inter- programmatic activities and external partnerships. OIP’s highest priorities include developing imaging agents and technologies for detecting, diagnosing, and treating cancer, and expanding our knowledge of animal models used for basic cancer research. OIP activities will pursue four specific aims. (1) Develop innovative imaging instruments and methods for diagnostic and theranostic applications and image-guided cancer therapies. (2) Develop new molecular imaging agents and theranostics for accurate detection and, assessment of tumor- specific properties as well as for monitoring therapeutic response to improve treatment outcomes. (3) Advance applications of quantitative imaging (QI) to elucidate the molecular mechanisms driving cancer progression and treatment responses via deep learning and radiomics. (4) Educate, train, and mentor students, fellows, and junior faculty in cancer imaging research. OIP will continue to develop strong intra- and inter-programmatic collaborations, industry partnerships, and integrated trainee support to champion collective innovation in cancer imaging research and clinical translation. The program currently includes 36 members from seven departments and three schools. The extensive collaborative network of OIP members has resulted in more than $10.1 million in current grant awards, of which $5.4 million is NCI funding and $2.5 million is other peer-reviewed funding, and an additional $5 million in NIH S10 large instrument grant funding. OIP research is anchored by one NCI-funded research center (Center for Multiple Myeloma Nanotherapy [U54 CA199092]), the institutionally supported Molecular Imaging Center (continuation of previous NCI-supported ICMIC [CA094056]), three NIH-supported Resource Centers (Gropler P41 EB025815, Marcus U24 CA204854, Shoghi U24 CA209837), two imaging training grants (Culver T32 EB014855, Woodard T32 EB021955), and more than 1,104 publications in the current project period of which 28% are inter-programmatic, 26% are intra-programmatic and 10% with impact factor >10. OIP research has been accelerated by recent installation of several new instruments, including PET/CT scanner (Siemens Vision), micro PET/CT, microPET/MR, GE SPINlab hyperpolarization unit, Oxford Instruments PulsarTM benchtop permanent-magnet-based 1.5-T NMR spectrometer, fluorescence molecular tomography system, multispectral optoacoustic tomography system, and IVIS-CT multimodal imaging system. Clinical translation of new discoveries will remain the cornerstone of OIP.

肿瘤学成像计划（OIP）：项目摘要肿瘤学成像程序（OIP）开发了新颖的成像剂和radiouclide的创新方法， MR，超声，光学和混合成像技术，包括光声成像和热词。人工智能和信息平台的应用来解决先进的肿瘤学成像挑战展示了OIP的不断发展的本质。 OIP的主要目标是促进新的研究计划，扩展正在进行的合作，精神少年教师，培训学生和研究员，并开发新方法来解决基本和临床癌成像需求。这些目标将通过内部和间程序化活动和外部伙伴关系。 OIP的最高优先事项包括开发成像代理以及用于检测，诊断和治疗癌症以及扩大我们对动物模型的知识的技术用于基本癌症研究。 OIP活动将追求四个具体目标。（1）开发创新成像诊断和热应用的仪器和方法以及图像引导的癌症疗法。（2）开发新的分子成像剂和热剂，以进行准确检测和评估肿瘤特定特性以及监测治疗反应以改善治疗结果。（3）进步定量成像（QI）的应用以阐明驱动癌症进展的分子机制和通过深度学习和放射组学的治疗反应。（4）教育，火车和精神学生，研究员和初中癌症成像研究的教师。 OIP将继续发展强大的和编程间合作，行业合作伙伴关系和综合实习生支持，为冠军癌症集体创新成像研究和临床翻译。该计划目前包括来自七个部门的36名成员和三所学校。 OIP成员的广泛合作网络已获得超过1,010万美元在当前的赠款奖中，其中540万美元是NCI资金，而250万美元是其他经过同行评审的资金，以及另外500万美元的NIH S10大型仪器赠款资金。 OIP研究由一个NCI资助研究中心（多发性骨髓瘤纳米疗法中心[U54 CA199092]），机构支持分子成像中心（以前的NCI支持ICMIC [CA094056]的延续），三个支持NIH的支持资源中心（Gropler P41 EB025815，Marcus U24 CA204854，Shoghi U24 CA209837），两次成像培训补助金（Culver T32 EB014855，Woodard T32 EB021955），其中有1,104多个出版物当前的项目期间，其中28％是程序间的，26％是截面性的，有撞击为10％因素> 10。最近安装了几种新工具，包括 PET/CT扫描仪（西门子视觉），微PET/CT，Micropet/MR，GE Spinlab超极化单元，牛津 Instruments PULSARTM台式永久性磁铁基于1.5-T NMR光谱仪，荧光分子断层扫描系统，多光谱光声断层扫描系统和IVIS-CT多模式成像系统。新发现的临床翻译将是OIP的基石。