Impact of sugars on tobacco product toxicity and abuse liability

糖对烟草产品毒性和滥用倾向的影响

基本信息

批准号：
10415960
负责人：
DOROTHY K HATSUKAMI
金额：
$ 42.11万
依托单位：
UNIVERSITY OF MINNESOTA
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-06-01 至 2024-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10415960
关键词：
Address Aldehydes American Behavior Behavioral Biological Markers Carcinogens Cessation of life Characteristics Chemicals Chemistry Cigarette Cigarette Smoker Data Disease Dose Electronic cigarette Epidemiology Filler Fructose Furans Glucose Goals Health Heating Human Inflammation Intake Knowledge Label Laboratories Laboratory Study Length Manufacturer Name Measures Menthol Morbidity - disease rate Nicotine Nitrosamines Oxidative Stress Palate Plants Population Process Property Public Health Reporting Research Research Priority Sensory Smoke Smoker Smoking Stable Isotope Labeling Sucrose Techniques Tobacco Tobacco Industry Tobacco smoke Tobacco use Toxic effect United States Food and Drug Administration Weight abuse liability base behavior measurement carcinogenicity cigarette smoke cigarette smoking demographics experimental study heated tobacco products mortality multidisciplinary statistics sugar tobacco products tool toxicant urinary ventilation

项目摘要

PROJECT SUMMARY Sugars, which are present naturally in some tobacco types and are also added to cigarette tobacco filler as additives, are not included in the FDA list of harmful and potentially harmful constituents (HPHC). Existing research data suggests that sugars in tobacco filler may contribute to the harmful properties of cigarettes in three critical ways: by enhancing smoke palatability and appeal and, as precursors to aldehydes and furans in the smoke, by increasing smoke toxicity and carcinogenicity and potentially addictiveness. Therefore, sugars are potentially the most versatile key constituents contributing to the smoking-associated morbidity and mortality. However, there is lack of robust quantitative data on the relationship between tobacco sugar content and relevant toxicant yields in U.S. commercial cigarettes, and the associated user exposures, behaviors, and cigarette appeal. In this study, we will leverage our combined expertise in tobacco chemistry, epidemiology, and human trials assessing biomarkers and behavioral and subjective measures, to address these key knowledge gaps. In Aim 1, we will use stable isotope-labeled sugars added to a commercial cigarette that is low in sugars and will analyze the dose-dependent formation of correspondingly labeled pyrolysis products in the smoke of this cigarette. to characterize the impact of sugars in the filler of U.S. cigarettes on the relevant chemical profile of cigarette smoke. We will also analyze the impact of sugar content on the levels of nicotine and tobacco-specific nitrosamines (TSNA) in the smoke. In Aim 2, we will analyze sugars in U.S. commercial cigarettes and use PATH biomarker data to investigate the impact of sugar content in cigarette tobacco on toxicant and carcinogen intake in U.S. smokers. In Aim 3, we will investigate the impact of sugar content in cigarette tobacco on cigarette abuse liability and appeal by conducting a laboratory study in which smokers will assess study cigarettes with differing levels of sugars in a laboratory setting. The overall goal of this proposal is to provide the FDA with the scientific basis to determine whether sugars should be added to HPHC list and whether their levels in tobacco products should be regulated.

项目摘要糖，在某些烟草类型中自然存在，也被添加到香烟烟草填充剂中添加剂不包括在有害和潜在有害成分的FDA清单中（HPHC）。现存的研究数据表明，烟草填充物中的糖可能有助于香烟的有害特性三种关键方法：通过增强烟气可口和吸引力，并作为醛和呋喃的先驱烟雾是通过增加烟雾毒性和致癌性和潜在上瘾性来增加的。因此，糖可能是有助于吸烟相关的发病率的最通用的关键成分死亡。但是，缺乏关于烟糖含量之间关系的强大定量数据以及美国商业香烟中的相关毒物产量，以及相关的用户暴露，行为和香烟上诉。在这项研究中，我们将利用我们在流行病学的烟草化学方面的综合专业知识，以及评估生物标志物以及行为和主观措施的人类试验，以解决这些关键知识差距。在AIM 1中，我们将使用添加到商业香烟中的稳定的同位素标记的糖低糖，将分析相应标记的热解产物的剂量依赖性形成这烟的烟。为了表征糖在美国香烟填充物中的影响香烟烟雾的化学轮廓。我们还将分析糖含量对尼古丁水平的影响和烟雾中的烟草特异性亚硝胺（TSNA）。在AIM 2中，我们将在美国商业广告中分析糖香烟并使用路径生物标志物数据研究糖含量在香烟烟草中的影响美国吸烟者中的有毒物质和致癌物摄入。在AIM 3中，我们将调查糖含量在通过进行实验室研究，吸烟者将对烟烟滥用责任和上诉，吸烟者将评估在实验室环境中糖水平不同的研究香烟。该提议的总体目标是为FDA提供科学依据，以确定是否应将糖添加到HPHC列表和是否应调节它们在烟草产品中的水平。