Animal Models and In Vivo Imaging Core

动物模型和体内成像核心

• 批准号: 10413122
• 负责人: Jeannie Chen
• 金额: $ 18.49万
• 依托单位: UNIVERSITY OF SOUTHERN CALIFORNIA
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-09-30 至 2023-09-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10413122
• 关键词: Address; Animal Disease Models; Animal Model; Basic Science; Center Core Grants; Consultations; Coupled; Development; Disease; Equipment; Evaluation; Experimental Animal Model; Genotype; Harvest; Image; Imaging Techniques; Individual; Molecular; Operative Surgical Procedures; Process; Research; Research Personnel; Resources; Sampling; Signs and Symptoms; Structure; Technical Expertise; Technology; Testing; Therapeutic; Tissue Harvesting; Tissues; Training; Translations; Vision research; animal imaging; cost; in vivo; in vivo imaging; instrument; instrumentation; investigator training; novel diagnostics; novel therapeutic intervention; ocular imaging; operation; vision science

Project Summary – Animal Models and In Vivo Imaging Core The Animal Models and In Vivo Imaging Core will meet the needs of participating investigators for using animal models of ocular diseases to conduct basic and translational vision research. The Core will provide access to advanced technologies and highly qualified technical support for generating and performing in vivo ocular imaging of animal models. The availability of animal models coupled with comprehensive in vivo tissue structure and function assessment will greatly accelerate study of molecular and cellular mechanisms underlying ocular disease processes, and facilitate translation of basic science findings for diagnostic and therapeutic applications. The specific aims are to provide instrumentation and technical expertise for: 1) generating and maintaining animal models of ocular diseases, performing surgical procedures, obtaining samples for genotyping, and harvesting ocular tissues; 2) enabling investigators to use various in vivo ocular imaging and tissue function testing technologies; 3) training investigators and research staff on the utility and operation of ocular imaging and function testing equipment; and 4) consultation regarding the appropriate animal models, surgical and imaging procedures to address research needs of participating investigators. .

项目摘要 - 动物模型和体内成像核心 动物模型和体内成像核心将满足参与研究人员使用动物的需求 眼部疾病的模型进行基本和翻译的视力研究。核心将提供对 高级技术和高素质的技术支持，用于在体内产生和执行体内眼镜 动物模型的成像。动物模型的可用性以及全面的体内组织的可用性 结构和功能评估将大大加速分子和细胞机制的研究 基本的眼部疾病过程，并促进基础科学发现的诊断和 治疗应用。具体目的是提供仪器和技术专长：1） 生成和维护眼部疾病的动物模型，进行手术程序，获得 用于基因分型和收集眼组织的样品； 2）使研究人员能够使用各种体内眼 成像和组织功能测试技术； 3）培训研究人员和研究人员有关该公用事业和 眼部成像和功能测试设备的操作； 4）有关适当的咨询 动物模型，手术和成像程序，以满足参与研究人员的研究需求。 。