Training in Drug Abuse and Brain Imaging

药物滥用和脑成像培训

• 批准号: 10410893
• 负责人: SCOTT E LUKAS
• 金额: $ 31.58万
• 依托单位: MCLEAN HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-07-10 至 2027-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10410893
• 关键词: Brain imaging; Drug abuse; Training

We propose to continue years 21-25 of a brain imaging and drug abuse postdoctoral T32 training program. We support this training via a variety of brain imaging tools that have yielded valuable insights into addictive disorders and related cognition. The need for such a dedicated program is driven by the emergence of innovative imaging techniques to evaluate both the anatomical and functional aspects of the brain under a variety of conditions related to substance use including acute intoxicating effects, cue-induced craving, cognitive effects, persistent neurological and cognitive defects, withdrawal, sleep disturbances, medication compliance, treatment progress and medications development. Because the nature and spectrum of the disciplines involved in imaging are broad and complex, a new breed of scientists with experience in imaging technology, multimodal analyses, neuroscience, pharmacology, addiction medicine and treatment is needed to more fully explore the neurobiological bases of drug abuse and fill the anticipated needs in the United States—our Training Program has been filling this void. Over the past 19 years we have successfully directed an integrated, multidisciplinary Drug Abuse and Brain Imaging Training Program that is supported by the outstanding environments offered by McLean Hospital/Harvard Medical School and by the Martinos Center for Biomedical Imaging at the MGH. We have trained 26 scientists over this period and all but one remains in the field. Our program emphasizes both clinical and translational research career development paths that have solid foundations in magnetic resonance [imaging, functional and spectroscopy], EEG, PET and Near Infrared Spectroscopy (NIRS). The training program infrastructure is built around two Siemens 3T clinical scanners (Prisma and new Trio upgrade to Prisma), a Varian 4T clinical scanner, a 9.4T small bore animal scanner, low- and high-density EEG/ERP and an Imagent NIRS system. Animal and clinical PET as well as 7T MRI are available at the Martinos Center. Our program also supports the hardware and offers training in how to analyze big data including working with datasets from the Human Connectome Project (HCP) and the Adolescent Brain Cognitive Development (ABCD) program. Our mentors are well funded by NIDA, NIAAA, and NIMH and so offer a unique breadth of research opportunities for our trainees. The program is designed to provide 2-3 years of training on the basics of imaging techniques as well as fundamental elements of drug abuse and psychiatry, followed by placement in one of four research tracks tailored to each trainee’s specific career goals: 1) Technology and Instrumentation; 2) Basic-Clinical; 3) Clinical/Treatment; and 4) Translational. The combination of didactic training in brain imaging and psychopharmacology with practical applications in a variety of highly successful research laboratories provide s our trainees with the skills to utilize a broad range of brain imaging techniques as they embark on the next decade of research into how drugs and alcohol affect the brain.

我们建议继续进行21 - 25年的大脑成像和药物滥用后T32培训计划。我们 通过各种大脑成像工具来支持此培训，这些工具对加性疾病产生了宝贵的见解 和相关认知。这种专用程序的需求是由创新成像的出现驱动的 在各种条件下评估大脑的解剖学和功能方面的技术 与药物使用有关，包括急性中毒作用，提示引起的渴望，认知效应 神经和认知缺陷，戒断，睡眠障碍，药物依从性，治疗进度 和药物开发。因为参与成像的学科的性质和频谱是广泛的 和Complex，这是一种具有成像技术经验的新型科学家，多模式分析， 需要神经科学，药理学，成瘾医学和治疗，以更全面地探索 药物滥用的神经生物学基础并满足美国的预期需求 - 我们的培训计划 一直在填补这个空白。在过去的19年中，我们成功地指导了一个综合的多学科 毒品滥用和大脑成像培训计划得到了提供的杰出环境的支持 麦克莱恩医院/哈佛医学院以及MGH的Martinos生物医学成像中心。我们 在此期间，已经培训了26位科学家，除一个外，所有其他人都保留在现场。我们的计划强调 临床和翻译的研究职业发展路径，在磁共振中具有稳固的基础 [成像，功能和光谱法]，脑电图，PET和近红外光谱法（NIRS）。培训计划 基础设施建于两个西门子3T临床扫描仪（Prisma和新的三人升级到Prisma），这是一个 Varian 4T临床扫描仪，9.4T小钻孔动物扫描仪，低密度和高密度EEG/ERP和成像 NIRS系统。马蒂诺斯中心提供动物和临床宠物以及7T MRI。我们的计划也是如此 支持硬件并提供有关如何分析大数据的培训，包括使用数据集 人类连接组项目（HCP）和青少年脑认知发展（ABCD）计划。我们的 导师由NIDA，NIAAA和NIMH充分资助，因此为研究机会提供了独特的研究机会 我们的学员。该计划旨在为成像技术的基础知识提供2 - 3年的培训 以及药物滥用和精神病学的基本要素，然后在四个研究轨道之一中放置 针对每个学员的特定职业目标量身定制：1）技术和仪器； 2）基本临床； 3） 临床/治疗； 4）翻译。大脑成像中的教学训练和 心理药理学在各种非常成功的研究实验室中具有实际应用，为您提供 我们的培训技巧，可以利用广泛的脑成像技术，他们将在未来十年开始 关于药物和酒精如何影响大脑的研究。