Animal Tumor Models

动物肿瘤模型

基本信息

批准号：
10411090
负责人：
Vittorio Sebastiano
金额：
$ 9.1万
依托单位：
STANFORD UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2007
资助国家：
美国
起止时间：
2007-06-04 至 2027-05-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10411090
关键词：
Algorithm Design Animal Model Animals Antibodies Area Biological Assay Budgets CRISPR/Cas technology Cancer Biology Cancer Center Support Grant Collaborations Cryoultramicrotomy Custom DNA Data Analyses Data Collection Drug Kinetics Fostering Funding Genetic Engineering Goals Guide RNA Histology Histopathology Image Immunohistochemistry Inbred BALB C Mice Institutes Knock-in Knock-out Knockout Mice Laboratories Magnetic Resonance Imaging Malignant Neoplasms Measurement Mediating Medicine Modality Modeling Mouse Strains Oncology Paraffin Pathologic Pathologist Pharmaceutical Preparations Pharmacodynamics Positron-Emission Tomography Production Protocols documentation Publications Research Research Design Research Personnel Resource Sharing Savings Series Service delivery model Services Sirius Red F3B Stains Surveys Technology Therapeutic Tissues Titrations Transgenic Animals Transgenic Mice Transgenic Organisms Translating Xenograft procedure animal resource base bioluminescence imaging cancer imaging cancer stem cell comparative cost cost effective cresyl violet design and construction experimental study genome editing member mouse genome mouse model oncology service pre-clinical preservation programs success tissue processing tumor

项目摘要

PROJECT SUMMARY The Animal Tumor Models Shared Resource (ATM-SR) provides services in three major areas: (i) transgenic and knockout mice, (ii) preclinical oncology, and (iii) animal histopathology services. The primary goal of the ATM-SR is to facilitate high-impact cancer-relevant research done by Stanford Cancer Institute (SCI) members by providing state-of-the-art and comprehensive animal resources. The transgenic and knockout mouse production services were established at Stanford in 1996 with the overall objective of providing genetically modified mouse models and associated supporting technologies to Stanford investigators at cost- effective rates. Preclinical oncology services, including study design, tumor induction, drug administration, PK and PD study, data collection and analysis, were initiated by the SCI in 2007. These services are provided by the Transgenic, Knockout and Tumor Model Center (TKTC). The Veterinary Service Center (VSC) in the Department of Comparative Medicine manages the animal histopathology service component of the shared resource. Major services include tumor analysis by histology, immunohistochemistry and pathological interpretation. Since the last review, the animal histology laboratory underwent a major renovation and expansion. In 2020, 45% of users were SCI investigators. Members from all programs regularly use the ATM- SR, with the heaviest use coming from the Cancer Biology and Cancer Stem Cells and Cancer Therapeutics programs. The ATM-SR contributed to over 17 cancer-focused SCI member publications since 2015; 10 of them were high-impact. The annual budget of the ATM-SR is $1,250,002 yet the CCSG request is $105,312. Accordingly, the ATM-SR leverages extensive institutional support and seeks only 8% from CCSG funds. The ATM-SR is focused on three major scientific aims: (1) to produce transgenic and knockout mice, (2) to provide preclinical oncology model services, and (3) to provide histopathology services.

项目概要动物肿瘤模型共享资源 (ATM-SR) 在三个主要领域提供服务：(i) 转基因和基因敲除小鼠，(ii) 临床前肿瘤学，以及 (iii) 动物组织病理学服务。该组织的首要目标是 ATM-SR 旨在促进斯坦福癌症研究所 (SCI) 进行的高影响力的癌症相关研究通过提供最先进和全面的动物资源来吸引会员。转基因和基因敲除鼠标生产服务于 1996 年在斯坦福大学成立，总体目标是提供以成本价向斯坦福大学研究人员提供转基因小鼠模型和相关支持技术有效率。临床前肿瘤学服务，包括研究设计、肿瘤诱导、给药、PK PD研究，数据收集和分析，由SCI于2007年发起。这些服务由转基因、基因敲除和肿瘤模型中心 (TKTC)。兽医服务中心 (VSC) 比较医学系管理共享的动物组织病理学服务部分资源。主要服务包括肿瘤组织学、免疫组织化学和病理学分析解释。自上次审查以来，动物组织学实验室进行了重大改造，扩张。 2020 年，45% 的用户是 SCI 研究者。所有计划的会员都定期使用 ATM- SR，最常用的是癌症生物学、癌症干细胞和癌症治疗程序。自 2015 年以来，ATM-SR 为超过 17 篇以癌症为重点的 SCI 成员出版物做出了贡献； 10 个他们的影响力很大。 ATM-SR 的年度预算为 1,250,002 美元，而 CCSG 的请求为 105,312 美元。因此，ATM-SR 利用广泛的机构支持，仅向 CCSG 资金寻求 8%。这 ATM-SR 专注于三个主要科学目标：(1) 生产转基因和基因敲除小鼠，(2) 提供临床前肿瘤学模型服务，(3) 提供组织病理学服务。