Training in Neural Control of organ Degeneration and Regeneration (NeuralCODR)

器官退化和再生的神经控制培训（NeuralCODR）

• 批准号: 10410250
• 负责人: Philip J Horner
• 金额: $ 17.66万
• 依托单位: METHODIST HOSPITAL RESEARCH INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-07-01 至 2027-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10410250
• 关键词: Natural regeneration; Organ; Training; neuroregulation

Neural activity directly controls the development and homeostasis of organ function. Yet, a surprising gap exists between laboratories focused on vascular, gastrointestinal, immune, and musculoskeletal systems and those focused on neurophysiology, neuromodulation, and neural injury. Traditionally, departments are organized by organ system and this siloed structure leads to a physical and scientific jargon separation, impeding collaboration and training. Hence, our understanding of how the central nervous system communicates with end organs throughout the body is in its infancy. Neural Control of Organ Degeneration and Regeneration (NeuralCODR), a cross-disciplinary training program unites 30 faculty members and 12 clinician researchers to form mentorship teams within the largest medical research center in the world (Texas Medical Center). Mentorship teams include a primary and secondary mentor (each from one of our three main areas of research: 1) neural development and tools, 2) neural innervation and organ engineering, and 3) nervous system and peripheral organ disorders) and a clinical mentor who provides much needed and rare exposure to real-world diseases, clinical challenges, and human samples. NeuralCODR aims to: 1) catalyze the collision of talent and ideas that spawn research projects bridging neuroscience with organ systems through facilitated interactions, 2) build co-mentor teams that include neuroscience, organ systems, and clinical perspectives, ensuring trainees are guided toward a unique research niche, and 3) train fellows in research rigor, analysis, and career skills that support their development as scientific leaders. NeuralCODR leverages a network of faculty who collaborate on projects that bridge the gap between organ system biology and engineering and neural function, degeneration and regeneration, as evidenced by an impressive list of multi-laboratory shared grants, publications, and nascent collaborations. The training structure emphasizes experiences in organ engineering and organ physiology laboratories in parallel with education in neurophysiology and neural engineering, translational theory, and practice. Currently, two NeuralCODR Houston Methodist-specific postdoctoral positions exist, thanks to a philanthropic endowment that has allowed us to build the program structure and to test both the coursework and mentorship team concept. Trainees are funded for two years, during which time they have access to a core curriculum, career development and program enrichment opportunities, symposiums/retreats, and elective courses. Year one culminates with the submission of an NRSA and a manuscript based on trainees’ development of a transformative research project that incorporates non-neuroscience expertise and tools into a neuroscience problem. Year two solidifies the relationships between the mentorship team and trainee and provides training in laboratory management, didactic teaching, and mentorship skills. T32 funding will allow us to increase the current model to six postdoctoral training slots. This training program will foster a new generation of scientific leaders who pioneer research on the connected pathways between brain and organ systems to solve fundamental challenges in neuroscience.

神经活动直接控制器官功能的发育和稳态。但是，存在一个令人惊讶的差距 在专注于血管，胃肠道，免疫和肌肉骨骼系统的实验室之间以及 专注于神经生理学，神经调节和神经膜。传统上，部门是由 器官系统和这种孤立的结构会导致物理和科学的行话分离，阻碍了协作 和培训。因此，我们对中枢神经系统如何与最终器官进行交流的理解 通过身体处于起步阶段。器官变性和再生的神经控制（NeuralCODR），A 跨学科培训计划单位30位教职员工和12名临床研究人员形成心态 世界上最大的医学研究中心（德克萨斯医学中心）的团队。指导团队包括 主要和中学的精神（每个研究之一）研究的三个主要领域之一：1）神经发展和 工具，2）神经元神经和器官工程，以及3）神经系统和周围器官疾病）和 一种临床心态，提供急需和罕见的现实疾病，临床挑战和 人类样品。 NeuralCodr的目的是：1）催化催生研究项目的人才和想法的碰撞 通过准备好的互动与器官系统桥接神经科学，2）建立包括 神经科学，器官系统和临床观点，确保受训者被引导到一项独特的研究 利基市场和3）在研究严格，分析和职业技能方面训练研究员，这些研究支持他们作为科学的发展 领导者。 NeuralCodr利用一个教师网络，该网络在弥合差距之间的项目上 器官系统生物学和工程以及神经功能，变性和再生，如 令人印象深刻的多样性共享赠款，出版物和新生合作的清单。训练结构 强调器官工程和器官生理实验室的经验与教育同行 神经生理学和神经工程，翻译理论和实践。目前，两个神经休斯顿 卫理公会特定的博士后职位存在，谢谢您的慈善捐赠，使我们能够建造 计划结构并测试课程工作和Mentalship Team概念。学员是为 两年，在此期间，他们可以访问核心课程，职业发展和计划 丰富的机会，研讨会/务虚会和选修课程。一年级最终提交 NRSA和基于培训的制定变革性研究项目的制定的手稿 将非神经科学专业知识和工具纳入神经科学问题。二年级巩固了 Mentalship团队与学员之间的关系，并提供实验室管理的培训 T32资金将使我们能够将当前型号增加到六个博士后培训 老虎机。该培训计划将培养新一代的科学领袖 在大脑和器官系统之间连接的途径，以解决神经科学中的基本挑战。