The University of Iowa's NeuroNEXT Clinical Research Site

爱荷华大学 NeuroNEXT 临床研究中心

基本信息

批准号：
10407623
负责人：
Katherine Dianne Mathews
金额：
$ 30.26万
依托单位：
UNIVERSITY OF IOWA
依托单位国家：
美国
项目类别：
财政年份：
2018
资助国家：
美国
起止时间：
2018-07-15 至 2024-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10407623
关键词：
Academic Medical Centers Adult Age Basic Science Centers for Disease Control and Prevention (U.S.)Child Clinical Clinical Investigator Clinical Research Clinical Trials Clinical Trials Cooperative Group Clinical Trials Design Clinical Trials Network Collaborations Communities Community Outreach Contracts Disease Education Educational Curriculum Epidemiologist Faculty Funding Geography Goals Institutes Institution Institutional Review Boards International Iowa Iowan Lead Leadership Learning Master&apos s Degree Mentors Mentorship Methodology Multicenter Studies Muscular Dystrophies National Center for Advancing Translational Sciences National Institute of Neurological Disorders and Stroke Nebraska Neurology Neuropathy Neurosciences Neurosciences Research North Dakota Pediatric Neurology Pediatric Research Pediatrics Persons Physicians Population Positioning Attribute Psychiatry Radiology Specialty Recording of previous events Research Research Design Research Institute Research Personnel Research Proposals Research Training Resources Role Rural Population Site South Dakota Tissue Banks Training Training Programs Translational Research United States National Institutes of Health Universities Vocational Guidance Work acute stroke career cerebrovascular clinical care clinical development clinical research site clinically relevant design dystroglycanopathy experience geographic barrier improved innovation multi-site trial nervous system disorder neurosurgery outreach outreach program pediatric patients programs recruit research and development research study rural setting service programs stroke therapy success training opportunity translational scientist translational study

项目摘要

The proposed University of Iowa Network for Excellence in Neuroscience Clinical Trials (UI NeuroNEXT) site has a long-standing history of leadership in clinical research with cross-departmental collaboration and involvement in clinical research networks. The UI NeuroNEXT site will capitalize on the interdisciplinary clinical research relationships already in place between the departments of Neurology, Pediatrics, Psychiatry, Neurosurgery, Radiology, the UI Institute of Clinical and Translational Research and the Institute for Neuroscience Initiatives. Unique to the UI NeuroNEXT clinical research site proposal is 1) the combined close leadership from the Departments of Neurology and Pediatrics (Child Neurology Division) with relationships across the state that enhance recruitment from a rural population and 2) experienced mentors and educators in clinical research and design including physicians, biostatisticians, and epidemiologists. The UI clinical neurology program services people across the state of Iowa and from surrounding states (e.g. North Dakota, South Dakota, and Nebraska). The population is quite stable, facilitating retention in studies. The UI’s unique ability to recruit and retain subjects with disease that span the range of potential NeuroNEXT proposals from a geographically stable, rural setting will enhance the broad applicability of any results from NeuroNEXT trials. As a result of the UI NeuroNEXT site’s extensive clinical research experience, the research coordinators associated with this proposal have many years of experience in neuroscience clinical trials. This experience further contributes to the excellent recruitment and retention of subjects in ongoing studies. The lead research coordinator and the lead pediatric research coordinator for this site are both experienced in management of multi-site trials similar to NeuroNEXT trials and will provide senior leadership for specific study coordinators. The pool for NeuroNEXT fellows will come from our junior faculty, current clinical and research fellows and residents who have completed the R25 research training program and are planning to develop a clinical research career. The education initiatives for early investigators and for the NeuroNEXT fellow will be led by the Career Enhancement Director, along with the co-PIs. The Clinical Trials Methodology Course, a national NIH funded training course for developing research proposals and led by one of the PIs for this proposal, will be an important resource. Another resource for fellows includes the UI ICTS clinical research curriculum that can lead to a Masters degree. NeuroNEXT fellows and other clinician researchers will also learn from their mentored involvement in NeuroNEXT studies. The UI NeuroNEXT clinical research site will be an active addition to the NeuroNEXT network. We will offer excellent recruitment and retention, and participate in NeuroNEXT committees and education initiatives. The Site will develop and submit clinical studies for consideration by the NeuroNEXT network and will work to increase the number of successful clinical researchers through educational opportunities.

拟议的爱荷华大学神经科学临床试验卓越网络（UI NeurOnext）网站在临床研究领域的领导力很长，跨部门协作并参与了临床研究网络。 UI Neuronext网站将利用神经病学，儿科，精神病学，神经外科，放射学，UI临床和转化研究所与神经科学研究所的跨学科临床研究关系。 UI Neuronext临床研究站点的独有的是1）神经病学和儿科（儿童神经病学部门）的综合领导力与全州的关系，从而增强了艰难的人群的招聘和2）临床研究和设计的导师和教育者，包括医师，生物统计学家，生物统计学家以及流行病学家。 UI临床神经病学计划为整个爱荷华州以及周边州（例如北达科他州，南达科他州和内布拉斯加州）提供服务。人口非常稳定，支持保留研究。 UI独特的招募和保留疾病受试者的能力跨越了从地理位置稳定的潜在神经元素质提案范围的范围，这将增强神经网毒试验中任何结果的广泛适用性。由于UI Neuronext网站的广泛临床研究经验，与该建议相关的研究协调员在神经科学临床试验方面具有多年的经验。这种经验进一步有助于在正在进行的研究中出色的招聘和保留受试者。该站点的主要研究协调员和主要儿科研究协调员都在类似于Neuronext试验的多站点试验的管理中经验丰富，并且将为特定的研究协调员提供高级领导。 Neuronext研究员的池将来自我们的初级教师，现任临床和研究研究员以及已完成R25研究培训计划并计划发展临床研究职业的居民。早期调查人员和Neuronext研究员的教育计划将由职业增强总监和Co-Pis领导。临床试验方法学课程是一项国家NIH资助的培训课程，用于制定研究建议，并由PI之一为此提案领导，这将是重要的资源。研究员的另一种资源包括UI ICTS临床研究课程，该课程可能会导致硕士学位。 Neuronext研究员和其他临床研究人员也将从他们参与Neuronext研究的指导中学习。 UI Neuronext临床研究网站将是神经网络网络的积极添加。我们将提供出色的招聘和保留率，并参与Neuronext承诺和教育计划。该站点将开发和提交临床研究，以供神经网络网络考虑，并将通过教育机会来增加成功的临床研究人员的数量。