CLINICAL OUTCOME MEASURES IN FRIEDREICH'S ATAXIA

弗里德赖希共济失调的临床结果测量

• 批准号: 7604880
• 负责人: Katherine Dianne Mathews
• 金额: $ 0.07万
• 依托单位: UNIVERSITY OF IOWA
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-03-01 至 2007-09-16
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7604880
• 关键词: Clinical; Computer Retrieval of Information on Scientific Projects Database; Disease; Friedreich Ataxia; Funding; Grant; Impairment; Individual; Institution; Measures; Neurologic; Outcome Measure; Patients; Performance; Purpose; Research; Research Personnel; Resources; Source; Therapy Clinical Trials; Time; United States National Institutes of Health; design; health related quality of life

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The purpose of this study is to validate clinical outcome measures in individuals with Friedreich Ataxia (FA). The lack of reliable and sensitive measures is the limiting factor in initiation of therapeutic trials in FA. The aims of the study are: 1) neurologic impairment in FA can be measured through quantitative performance measures; 2) health-related quality of life measures will correlate significantly with clinical measures of disease activity designed in Aim 1; 3) simple performance measures of neurologic impairments will be responsive to change over time in patients with FA.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目及 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 本研究的目的是验证弗里德赖希共济失调 (FA) 患者的临床结果测量。 缺乏可靠和敏感的措施是 FA 治疗试验启动的限制因素。 该研究的目的是：1）FA 的神经功能障碍可以通过定量表现测量来测量； 2) 与健康相关的生活质量测量将与目标 1 中设计的疾病活动的临床测量显着相关； 3) 神经功能障碍的简单表现测量将对 FA 患者随时间的变化做出反应。