Hidden Hearing Loss: A View from the Brain

隐性听力损失：大脑的视角

基本信息

批准号：
10400159
负责人：
SUSAN E SHORE
金额：
$ 50.58万
依托单位：
UNIVERSITY OF MICHIGAN AT ANN ARBOR
依托单位国家：
美国
项目类别：
财政年份：
2018
资助国家：
美国
起止时间：
2018-06-07 至 2024-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10400159
关键词：
Acoustic Nerve Action Potentials Affect Amplifiers Animals Area Auditory Brainstem Responses Auditory Threshold Auditory area Axon Brain Cavia Cells Clinical Cochlea Cochlear nucleus Code Data Electrodes Electrophysiology (science)Environment Frequencies Fusiform Cell Goals Health Hearing Hearing Tests Histologic Human Impairment Injections Inner Hair Cells Label Lasers Masks Medial Methods Nerve Fibers Neurons Noise Output Physiology Play Role Route Series Signal Transduction Speech Speech Perception Stimulus Synapses System Temporal bone structure Temporary Threshold Shift Thalamic structure Tracer Transfection Virus experimental study hidden hearing loss improved magnocellular neuronal circuitry noise exposure normal hearing optogenetics photoactivation receptive field reconstruction response sound stellate cell

Acoustic Nerve Action Potentials Affect Amplifiers Animals Area Auditory Brainstem Responses Auditory Threshold Auditory area Axon Brain Cavia Cells Clinical Cochlea Cochlear nucleus Code Data Electrodes Electrophysiology (science)Environment Frequencies Fusiform Cell Goals Health Hearing Hearing Tests Histologic Human Impairment Injections Inner Hair Cells Label Lasers Masks Medial Methods Nerve Fibers Neurons Noise Output Physiology Play Role Route Series Signal Transduction Speech Speech Perception Stimulus Synapses System Temporal bone structure Temporary Threshold Shift Thalamic structure Tracer Transfection Virus experimental study hidden hearing loss improved magnocellular neuronal circuitry noise exposure normal hearing optogenetics photoactivation receptive field reconstruction response sound stellate cell

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项目摘要

Abstract The concept of “hidden” hearing loss challenges the idea that temporary threshold shifts (TTS) reflect a return to normal hearing. Recent studies indicate that after noise-exposure that produces TTS, and thus clinically 'normal' audiograms, there is nonetheless permanent damage to auditory nerve fiber (ANF) synapses with cochlear inner hair cells. Hidden hearing loss is a potential major health issue, as human temporal bone and ABR studies suggest it is common in humans. The remaining perceptual deficits in humans with clinically normal audiograms reflect temporal coding problems likely due to loss of the high threshold, low spontaneous rate ANFs, which are preferentially affected after TTS. The primary central targets of high-threshold ANFs reside in the small cell cap (SCC) of the cochlear nucleus (CN). High-threshold ANFs and their SCC targets display large dynamic ranges and superior suprathreshold tuning and temporal coding, which are essential for speech perception in noisy environments. The SCC occupies a large proportion of the CN in humans and is therefore poised to play a major role in central mechanisms of hidden hearing loss. The SCC is unique also as a putative recipient and projection area of medial olivocochlear (MOC) neurons. The overall hypothesis of this proposal is that the SCC plays a major role in suprathreshold sound coding and that this coding is highly susceptible to degradation by hidden hearing loss. The goal of this series of studies is to elucidate the cochlea- SCC-MOC circuit in normal and noise-damaged animals with hidden hearing loss, using state-of-the-art optogenetics, multichannel single unit physiology, tract tracing and sophisticated immunohistochemical methods.

抽象的 “隐藏”听力损失的概念挑战了临时阈值转移（TTS）反映回报的观念正常听力。最近的研究表明，产生TT的噪声暴露后，因此在临床上 “正常的”听力图，尽管有听觉神经纤维（ANF）突触的永久性损害耳蜗内毛细胞。隐藏的听力损失是一个潜在的重大健康问题，因为人类临时骨骼和 ABR研究表明它在人类中很常见。其余的感知在临床上的人类中定义正常的听力图反映了暂时的编码问题可能是由于高阈值损失而导致的评分ANF，最好在TT之后受到影响。高阈值Anfs的主要核心目标驻留在耳蜗核（CN）的小细胞帽（SCC）中。高阈值ANFS及其SCC目标显示较大的动态范围和出色的上方调整和临时编码，这对于噪声环境中的语音感知。 SCC在人类中占据了CN的很大一部分因此，中毒在隐藏听力损失的中心机制中发挥了重要作用。 SCC也是独一无二的内侧橄榄石（MOC）神经元的假定受体和投影区域。总体假设建议是SCC在Suprathratherhold声音编码中起着重要作用，并且该编码很高容易因隐藏的听力损失而降解。这一系列研究的目的是阐明耳蜗使用最先进的scc-moc电路在正常和噪声损害的动物中，使用最先进的动物光遗传学，多通道单位生理学，道跟踪和复杂的免疫组织化学方法。