Function of the Trigeminal Ganglion-Cochlear Nucleus

三叉神经节-耳蜗核的功能

• 批准号: 6516285
• 负责人: SUSAN E SHORE
• 金额: $ 26.34万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-04-01 至 2006-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6516285
• 关键词: auditory nuclei; auditory pathways; auditory stimulus; brain stem; electronic stimulator; electrostimulus; ganglions; guinea pigs; immunocytochemistry; neurons; neuropharmacology; neurophysiology; neurotransmitters; nitric oxide; single cell analysis; stereotaxic techniques; stimulus /response; substance P; tinnitus; trigeminal nerve; auditory nuclei; auditory pathways; auditory stimulus; brain stem; electronic stimulator; electrostimulus; ganglions; guinea pigs; immunocytochemistry; neurons; neuropharmacology; neurophysiology; neurotransmitters; nitric oxide; single cell analysis; stereotaxic techniques; stimulus /response; substance P; tinnitus; trigeminal nerve

DESCRIPTION: (Adapted from applicant's abstract): We have demonstrated that the trigeminal ganglion sends a projection to the auditory brain stem and to the cochlear vasculature. The terminations in the brainstem end in granular and magnocellular regions of the ventral cochlear nucleus (VCN) and at the locations of olivocochlear neurons in the superior olivary complex. The cochlear portion of the innervation modulates blood flow within the cochlea. However, the function of the brainstem projection is unknown. Preliminary findings suggest that the projection to the VCN is excitatory. The axons of granule' cells (parallel fibers) project to the dorsal cochlear nucleus (DCN). Therefore, excitation by the trigeminal innervation could affect most of the output neurons of the cochlear nucleus (CN). A series of studies is designed to elucidate the function of the CN portion of this new projection and define its neurotransmitters: The trigeminal ganglion will be electrically stimulated while observing the responses of single units in the CN. The candidate neurotransmitters, Substance P and Nitric Oxide, will be evaluated using immunocytochemistry and neuropharmacology. A role for the trigeminal ganglion in the generation and modulation of tinnitus will be explored: As many as two thirds of tinnitus patients are able modulate their tinnitus by clenching the jaw or touching the skin on the face, areas innervated by the trigeminal ganglion. Others can attribute the onset of tinnitus to a somatic insult in the head and neck region ("somatic tinnitus"). On the assumption that increased spontaneous rate is a manifestation of tinnitus, its modulation by somatosensory input to the CN could play a role in the generation and modulation of tinnitus. The hypothesis wifi be tested by electrically stimulating the trigeminal ganglion while recording spontaneous activity in single units of the CN. Identifying the neurotransmitter used in this pathway could then set the stage for later drug treatments.

描述：（改编自申请人的摘要）：我们已经证明了 三叉神经节将投影发送给听觉脑干和人工耳蜗 脉管系统。脑干在颗粒和大细胞上的终止 腹侧耳蜗核（VCN）和橄榄石位置的区域 上橄榄络合物中的神经元。神经的耳蜗部分 调节耳蜗内的血液流动。 但是，脑干的功能 投影未知。初步发现表明对VCN的投影 是兴奋的。颗粒细胞（平行纤维）的轴突向背部发射 耳蜗核（DCN）。因此，三叉神经的激发 可能影响人工耳蜗（CN）的大多数输出​​神经元。系列 研究旨在阐明该新的CN部分的功能 投影并定义其神经递质： 三叉神经节将在观察时进行电刺激 CN中单个单元的响应。候选神经递质，物质 P和一氧化氮将使用免疫细胞化学和 神经药理学。三叉神经节在这一代人中的作用 耳鸣的调节将探讨：多达三分之二的耳鸣 患者能够通过紧握下颌或触摸 脸上的皮肤，三叉神经神经支配的区域。其他人可以 将耳鸣的发作归因于头部和颈部区域的躯体侮辱 （“躯体耳鸣”）。假设自发率提高为 耳鸣的表现，其通过体感觉输入到CN的调节 可以在耳鸣的产生和调节中发挥作用。假设 WiFi通过电刺激三叉神经节来测试 记录CN单元中的自发活动。识别 然后在此途径中使用的神经递质可以为以后的药物设定阶段 治疗。