National Pediatric Rehabilitation Resource Center

国家儿科康复资源中心

• 批准号: 10400681
• 负责人: SHARON LANDESMAN RAMEY
• 金额: $ 96.19万
• 依托单位: VIRGINIA POLYTECHNIC INST AND ST UNIV
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-05-15 至 2025-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10400681
• 关键词: Address; Advertising; Affect; Archives; Biomedical Engineering; Biotechnology; Cerebral Palsy; Child; Childhood; Clinical; Clinical Research; Clinical Trials; Clinical and Translational Science Awards; Collaborations; Communities; Complex; Data; Development; Discipline; Disease; Educational workshop; Ensure; Evaluation; Evidence based intervention; Evidence based treatment; Funding; Health; Impairment; Individual; Institution; Interdisciplinary Study; Knowledge; Leadership; Manuals; Measurement; Mentors; Monitor; Multi-Institutional Clinical Trial; National Institute of Child Health and Human Development; National Institute of Neurological Disorders and Stroke; Neurosciences; Occupational Therapy; Ohio; Onset of illness; Outcome; Parents; Patients; Pediatric Hospitals; Pediatric Neurology; Phase; Physical therapy; Pilot Projects; Population; Productivity; Quality of life; Randomized Controlled Trials; Regulation; Rehabilitation therapy; Reporting; Research; Research Design; Research Infrastructure; Research Personnel; Resources; Role; Science; Strategic Planning; Techniques; Testing; Training Programs; United States National Institutes of Health; Universities; Update; Virginia; Vision; Work; biobehavior; design; disability; effective therapy; efficacious intervention; functional outcomes; implementation science; improved; improved functioning; innovation; neurobiological mechanism; neuroimaging; novel strategies; outreach; programs; rehabilitation research; rehabilitation science; special interest group; success; technique development; webinar

Project Summary (Overall) We propose a National Pediatric Rehabilitation Resource Center (PedRehab Ctr) to offer research infrastructure supports to improve investigators' capacity to conduct rigorous clinical trials to test and implement evidence-based interventions in pediatric medical rehabilitation. Our specific aims are: 1) to provide an active and archived program of courses, workshops, webinars, and demonstrations related to the design, conduct, analysis, and reporting of high-quality, high-impact clinical trials - including complex, multicomponent, and multiphase treatments (Didactic Interactions); 2) to support interdisciplinary research collaborations that promote innovation and excellence in conducting multi-site clinical trials (Mentored Collaborative Opportunities); 3) to develop critically needed techniques in measurement and understanding of neurobiological mechanisms and biobehavioral outcomes in pediatric medical rehabilitation (Techniques Development); 4) to fund pilot studies via partnerships with leading national organizations to yield data for informing competitive NIH applications in pediatric medical rehabilitation (Pilot Studies); and 5) to promote PedRehab Ctr expertise by advertising and coordinating with major associations and to prepare a much-needed comprehensive, interdisciplinary reference manual (online and dynamically updated) addressing issues inherent in pediatric medical rehabilitation research (Promoting Center Expertise). Our analysis of critical gaps, obstacles, and opportunities in pediatric rehabilitation research informs the strategies we propose to achieve these aims. The administrative organization and operational plan for PedRehab Ctr will realize efficiencies, leverage resources, and ensure broad outreach through partnerships with leading organizations, research networks, and special interest groups. PedRehab Ctr will convene a National Advisory Group with patient/parent representation to assist in plans for and evaluation of PedRehab Ctr activities. PedRehab Ctr proposes approaches to increase diversity in the pediatric rehabilitation workforce and research. Our PedRehab Ctr core team at Virginia Tech, The Ohio State University, and Nationwide Children's Hospital has deep expertise and unique labs that support developmental science, neuroimaging, pediatric neurology, occupational therapy, physical therapy, medical rehabilitation science, bioengineering, research design and regulations, and Implementation Science. PedRehab Ctr activities will build on our leadership roles in NIH multisite randomized controlled trials (Phase II and III), our Clinical and Translational Science Awards (CTSAs), NIH research networks, NIH training programs in translational biomedical and implementation science, and national organizations. Collectively, PedRehab Ctr has the potential to increase the number of scientifically rigorous, productive, and high-impact clinical trials in pediatric medical rehabilitation. In turn, the expansion and effective implementation of scientific findings from these trials will likely produce widespread and enduring improvements in functional outcomes, health, and productivity of individuals affected by childhood-onset disorders and disabilities.

项目摘要（总体） 我们建议一个国家儿科康复资源中心（PEDREAB CTR）提供研究 基础设施支持提高研究人员进行严格临床试验的能力，以测试和实施 小儿医疗康复的循证干预措施。我们的具体目的是：1） 以及与设计，行为，研讨会，网络研讨会和演示的课程归档计划 分析和报告高质量，高影响的临床试验 - 包括复杂，多组分和 多相处理（教学相互作用）； 2）支持促进的跨学科研究合作 进行多站点临床试验（指导的协作机会）方面的创新和卓越； 3）到 在测量和理解神经生物学机制和 小儿医学康复的生物行为结果（技术开发）； 4）通过 与领先国家组织的合作伙伴关系，以产生数据，以告知NIH的竞争性NIH申请 小儿医疗康复（试点研究）； 5）通过广告和 与主要协会进行协调，并准备急需的全面，跨学科参考 手册（在线和动态更新）解决儿科医疗康复研究固有的问题 （促进中心专业知识）。我们对小儿康复的关键差距，障碍和机遇的分析 研究为我们提出的实现这些目标的策略提供了信息。 PEDREAB CTR的行政组织和运营计划将实现效率，杠杆作用 资源，并通过与领先的组织，研究网络和 特殊利益集团。 Pedrehab CTR将与患者/家长代表召集一个国家咨询小组 协助PEDREAB CTR活动的计划和评估。 PEDREAB CTR提出了增加的方法 小儿康复劳动力和研究的多样性。我们在弗吉尼亚理工大学的Pedrehab CTR核心团队 俄亥俄州立大学和全国儿童医院拥有深厚的专业知识和独特的实验室来支持 发展科学，神经影像学，儿科神经病学，职业疗法，物理治疗，医学 康复科学，生物工程，研究设计和法规以及实施科学。小猫 CTR活动将以我们在NIH多站点随机对照试验（II阶段和III）中的领导作用为基础 临床和转化科学奖（CTSA），NIH研究网络，NIH培训计划 转化生物医学和实施科学以及国家组织。 pedrehab ctr共同 增加科学严格，生产性和高影响力临床试验数量的潜力 小儿医疗康复。反过来，扩展和有效实施了科学发现 这些试验可能会在功能结果，健康和 受儿童期疾病和残疾影响的个人的生产力。