The Harvard Clinical and Translational Science Center

哈佛临床与转化科学中心

• 批准号: 10398988
• 负责人: Lee Marshall Nadler
• 金额: $ 1286.73万
• 依托单位: HARVARD MEDICAL SCHOOL
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-05-01 至 2023-06-15
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10398988
• 关键词: Address; Agreement; Attention; Biological Sciences; Center for Translational Science Activities; Clinical Research; Clinical Sciences; Clinical Trials; Clinical Trials Network; Collaborations; Communities; Competence; Complex; Conceptions; Data; Data Set; Development; Diagnosis; Discipline; Eagles; Ecosystem; Electronic Health Record; Ensure; Evaluation; Evolution; Faculty; Fostering; Future; Goals; Grant; Health; Health Sciences; Healthcare; Human; Incentives; Individual; Informatics; Infrastructure; Institutional Review Boards; Knowledge; Learning; Longevity; Medical Students; Methodology; Methods; Mission; National Center for Advancing Translational Sciences; Ohio; Oregon; Patients; Performance; Population; Process; Research Methodology; Research Personnel; Resources; Risk; Schedule; Schools; Science; Special Population; Speed; Sum; System; Talents; Technology; Training; Training Support; Translational Research; Translations; Universities; Workforce Development; catalyst; clinical translation; cohort; education resources; evidence base; experimental study; graduate student; improved; informatics infrastructure; innovation; member; multidisciplinary; new technology; next generation; open innovation; open source; prevent; research study; skills; success; systems research; tool; translational research program; Address; Agreement; Attention; Biological Sciences; Center for Translational Science Activities; Clinical Research; Clinical Sciences; Clinical Trials; Clinical Trials Network; Collaborations; Communities; Competence; Complex; Conceptions; Data; Data Set; Development; Diagnosis; Discipline; Eagles; Ecosystem; Electronic Health Record; Ensure; Evaluation; Evolution; Faculty; Fostering; Future; Goals; Grant; Health; Health Sciences; Healthcare; Human; Incentives; Individual; Informatics; Infrastructure; Institutional Review Boards; Knowledge; Learning; Longevity; Medical Students; Methodology; Methods; Mission; National Center for Advancing Translational Sciences; Ohio; Oregon; Patients; Performance; Population; Process; Research Methodology; Research Personnel; Resources; Risk; Schedule; Schools; Science; Special Population; Speed; Sum; System; Talents; Technology; Training; Training Support; Translational Research; Translations; Universities; Workforce Development; catalyst; clinical translation; cohort; education resources; evidence base; experimental study; graduate student; improved; informatics infrastructure; innovation; member; multidisciplinary; new technology; next generation; open innovation; open source; prevent; research study; skills; success; systems research; tool; translational research program

Contact PD/PI: Nadler, Lee Marshall OVERALL: ABSTRACT By convening, connecting, and catalyzing the formation of multi-institutional, cross-disciplinary teams from across Harvard's (HU) 10 schools and 16 independent academic health centers (AHCs), Harvard Catalyst (HC) has fostered a “One Harvard” community and culture that has transformed the quality, efficiency, and impact of clinical and translation (CT) research at HU. HC's commitment to make the whole of the HU CT research enterprise greater than the sum of its parts has led to the development and continuous evolution of 12 innovative and integrated Cores focused on training the 21st century CT workforce, addressing the needs of patients and their communities, and incentivizing and prioritizing collaboration, team science, and stakeholder engagement. HC Cores have developed workflows, processes, methodologies, tools, and technologies to support the training and needs of T0-T4 CT investigators, their teams, community stakeholders, and the HU ecosystem, and have collected qualitative and quantitative data to demonstrate their value at HU hub. Once demonstrated, HC shares its learning as open source with other CTSAs and the CTSA consortium. To date, Profiles, i2b2 SHRINE (now Accrual to Clinical Trials ACT Network), Master Reliance Agreements and online reliance systems (now SMART IRB), eagle-i, Scheduler, online educational resources (initiating the N-lighten Network), and open innovation experiments have been disseminated to the CTSA consortium. Going forward to fully align with NCATS' strategic goals, HC will implement five specific aims: Workforce Development (Aim 1) will support the broadly defined educational needs of the present and future CT workforce inclusive of all CT research domains, disciplines, medical and graduate students, post-graduate trainees, investigators, multi-disciplinary team members, and communities of collaborators. Research Methods and Processes (Aim 2) will provide “everything necessary” to execute CT research including methods, processes, workflows, pilot grants, novel technologies, and integrated data sets necessary for investigators and their teams to succeed locally and in collaboration with communities and the CTSA consortium. Integration (Aim 3) will ensure that translational science is interconnected across all T domains and is inclusive of the needs of special populations and individuals across their entire lifespan. Collaboration and Engagement (Aim 4) will promote team science by extending the CT research community beyond its traditional academic borders. It engages and partners with our patients, communities, and our diverse ecosystem to participate in prioritization decisions and gap analysis. Informatics (Aim 5) will respond to the needs of CT investigators, teams, patients, and communities by providing enabling processes, methodologies, and tools. HC Learning CT Research System will enable HC to study the science of CT science and develop evidence-based strategies to improve the conduct of CT research thereby increasing its impact on human health. HC will continue to share all resources developed and lessons learned with the CTSA consortium. Project Summary/Abstract Page 362 Contact PD/PI: Nadler, Lee Marshall Harvard Catalyst | The Harvard Clinical and Translational Science Center, connects, convenes, and catalyzes the faculty, trainees, and teams from across Harvard's 10 Schools and 16 Academic Healthcare Center to partner with its communities and biomedical ecosystem to address NCATS' five strategic goals to improve health.

联系PD/PI：Nadler，Lee Marshall 总体：摘要 通过召集，联系和催化来自 在哈佛大学（HU）的10所学校和16个独立的学术保健中心（AHC），哈佛催化剂 （HC）培养了一个“哈佛大学”社区和文化，它改变了质量，效率和 HU临床和翻译（CT）研究的影响。 HC致力于整个HU CT 研究企业大于其部分的总和，导致了发展的发展和持续发展 12创新和综合的核心侧重于培训21世纪CT劳动力，以满足 患者及其社区，激励和优先考虑合作，团队科学和利益相关者 订婚。 HC核心开发了工作流，过程，方法，工具和技术 支持T0-T4 CT调查人员，他们的团队，社区利益相关者和HU的培训和需求 生态系统，并收集了定性和定量数据，以证明其在HU中心的价值。一次 HC证明，与其他CTSA和CTSA联盟共享其作为开源的学习。迄今为止， 个人资料，I2B2神社（现为临床试验法ACT网络），主要信仰协议和在线 Reliance Systems（现为智能IRB），Eagle-I，调度程序，在线教育资源（启动N-Lighten 网络）和开放创新实验已被传播到CTSA联盟。 将与NCAT的战略目标完全保持一致，HC将实施五个具体目标：劳动力队伍 开发（AIM 1）将支持当前和未来CT的广泛定义的教育需求 包括所有CT研究领域，学科，医学和研究生，后级的劳动力 受训者，调查人员，多学科团队成员和合作者社区。研究方法 过程（AIM 2）将提供“一切必要的”来执行CT研究，包括方法， 研究人员所需的过程，工作流程，试点赠款，新技术和集成数据集 他们的团队将在当地取得成功，并与社区和CTSA财团合作。一体化 （AIM 3）将确保转化科学在所有T领域互连，并且包括 特殊人群和个人整个生命的需求。合作与参与（目标 4）将通过将CT研究社区扩展到其传统学术范围之外，从而促进团队科学 边界。它与我们的患者，社区和我们的潜水员生态系统与之互动并合作 优先决定和差距分析。信息学（AIM 5）将响应CT调查人员的需求， 通过提供启用流程，方法和工具，团队，患者和社区。 HC学习CT 研究系统将使HC能够研究CT科学的科学，并制定基于证据的策略 改善CT研究的行为，从而增加其对人类健康的影响。 HC将继续分享 开发了所有资源，并从CTSA财团中学到了教训。 项目摘要/摘要页面362 联系PD/PI：Nadler，Lee Marshall 哈佛催化剂|哈佛临床和转化科学中心，连接，召集和催化 来自哈佛大学的10所学校和16个学术医疗中心的教职员工，学员和团队 伴随着其社区和生物医学生态系统，以探讨NCAT的五个战略目标，以改善健康状况。