TBD

待定

• 批准号: 10399838
• 负责人: Steven P Jones
• 金额: $ 25万
• 依托单位: UNIVERSITY OF LOUISVILLE
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-07-01 至 2023-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10399838
• 关键词: Acute; Animal Model; Animals; Area; Arts; Award; Basic Science; Biomedical Research; Blood Vessels; Cardiometabolic Disease; Cardiovascular Diseases; Cardiovascular system; Cause of Death; Centers of Research Excellence; Clinical; Complement; Core Facility; Country; Data; Development; Diabetes Mellitus; Discipline; Disease; Endocrine; Ensure; Environment; Environmental Exposure; Epidemic; Event; Excess Mortality; Faculty; Flow Cytometry; Fostering; Foundations; Funding; Goals; Grant; Growth; Health; Human; Image; Individual; Inflammation; Infrastructure; Institution; Insulin Resistance; Interdisciplinary Study; Investigation; Laboratories; Lead; Learning; Medicine; Mentors; Mentorship; Metabolic; Metabolism; Molecular; Myocardial Infarction; Non-Insulin-Dependent Diabetes Mellitus; Obesity; Pathology; Phase; Phenotype; Physiology; Pilot Projects; Postdoctoral Fellow; Public Health Schools; Research; Research Infrastructure; Research Personnel; Research Project Grants; Research Support; Research Training; Resources; Risk Factors; Science; Seeds; Services; Solid; Stroke; Therapeutic; Training; Translational Research; United States National Institutes of Health; Universities; Vascular Diseases; Work; base; cardiovascular disorder risk; career; career development; clinical investigation; diabetic; graduate student; innovation; interdisciplinary approach; interest; member; multidisciplinary; novel; prevent; programs; recruit; stem cell biology; sudden cardiac death; Acute; Animal Model; Animals; Area; Arts; Award; Basic Science; Biomedical Research; Blood Vessels; Cardiometabolic Disease; Cardiovascular Diseases; Cardiovascular system; Cause of Death; Centers of Research Excellence; Clinical; Complement; Core Facility; Country; Data; Development; Diabetes Mellitus; Discipline; Disease; Endocrine; Ensure; Environment; Environmental Exposure; Epidemic; Event; Excess Mortality; Faculty; Flow Cytometry; Fostering; Foundations; Funding; Goals; Grant; Growth; Health; Human; Image; Individual; Inflammation; Infrastructure; Institution; Insulin Resistance; Interdisciplinary Study; Investigation; Laboratories; Lead; Learning; Medicine; Mentors; Mentorship; Metabolic; Metabolism; Molecular; Myocardial Infarction; Non-Insulin-Dependent Diabetes Mellitus; Obesity; Pathology; Phase; Phenotype; Physiology; Pilot Projects; Postdoctoral Fellow; Public Health Schools; Research; Research Infrastructure; Research Personnel; Research Project Grants; Research Support; Research Training; Resources; Risk Factors; Science; Seeds; Services; Solid; Stroke; Therapeutic; Training; Translational Research; United States National Institutes of Health; Universities; Vascular Diseases; Work; base; cardiovascular disorder risk; career; career development; clinical investigation; diabetic; graduate student; innovation; interdisciplinary approach; interest; member; multidisciplinary; novel; prevent; programs; recruit; stem cell biology; sudden cardiac death

ABSTRACT This application is to support Phase III of the COBRE-supported Diabetes and Obesity Center at the University of Louisville. The Center was established in 2008, with the central objective of supporting molecular, cellular, experimental, translational and clinical investigations into the cardiovascular causes and consequences of diabetes and obesity. During Phase I and II, the Center underwent phenomenal growth. It has facilitated the career development of junior investigators, provided core support to investigators involved in diabetes, obesity and cardiovascular research, and has provided training and mentorship to graduate students and post-doctoral fellows. The goal in Phase III is to provide sustainable core support to Center investigators and strengthen diabetes and obesity research at the institution; to maintain and enhance state-of-the-art infrastructure, foster research and support basic and translational research within the thematic focus of the Center. In Phase III, the Center will support 5 Cores – Core A: An Administrative Core, Core B: Flow Cytometry Core, Core C, Pathology and Bioanlytics Core, Core D: Animal Models and Phenotyping Core, and Core E: Imaging and Physiology Core. The Center will also support a Pilot Project Program to stimulate new research by providing seed funding to promising projects that could obtain extramular funding. The Center provides unique opportunities for research in the areas of cardiovascular metabolism, inflammation and cardiometabolic disease, stem cell biology, and environmental determinants of cardiometabolic disease. A dynamic, self-sustaining Diabetes and Obesity Center at the University of Louisville will not only provide fertile ground for innovative studies in the area of diabetes, obesity, and cardiovascular research, but it will enable the institution to become an enduring hub of learning, mentoring, training, and fostering academic excellence.

抽象的 该应用是为了支持毛绒糖尿病和肥胖中心的第三阶段 路易斯维尔大学。该中心成立于2008年，其核心目的是 支持分子，细胞，实验，转化和临床研究 糖尿病和肥胖的心血管原因和后果。在第一阶段和第二阶段， 中心经历了惊人的生长。它已经准备好了初中的职业发展 调查人员为参与糖尿病，肥胖和 心血管研究，并为研究生和 博士后研究员。第三阶段的目标是为中心提供可持续的核心支持 该机构的研究人员和强大的糖尿病和肥胖研究；维护和 增强最先进的基础架构，促进研究和支持基础和翻译 中心主题重点的研究。在第三阶段，该中心将支持5个核心 - 核心A：行政核心，核心B：流式细胞仪核心，核心C，病理和生物异化 核心，核心D：动物模型和表型核心以及核心E：成像和生理核心。 该中心还将支持一项试点项目计划，以通过提供种子来刺激新研究 资助可以获得可以获得外部资金的项目。该中心提供了独特的 在心血管代谢，创新和 心脏代谢性疾病，干细胞生物学和心脏代谢的环境决定剂 疾病。路易斯维尔大学的动态，自我维持的糖尿病和肥胖中心 不仅将为糖尿病，肥胖和肥胖领域的创新研究提供肥沃的基础 心血管研究，但它将使该机构成为一个持久的学习中心， 指导，培训和促进学术卓越。