Myocardial Reperfusion Injury: Insights Gained from Gene-Targeted Mice.

Myocardial ischemia-reperfusion injury involves activation of multiple cell types, including leukocytes and endothelial cells. The pursuant inflammation involves diminished nitric oxide production, influx of neutrophils, and myocardial cell injury. Gene-targeted animals provide important clues about the progression of this inflammatory cascade.

心肌缺血再灌注损伤涉及多种细胞类型的激活，包括白细胞和内皮细胞。随之而来的炎症包括一氧化氮生成减少、中性粒细胞流入以及心肌细胞损伤。基因靶向动物为这种炎症级联反应的进展提供了重要线索。