HERCULES: Exposome Research Center

HERCULES：暴露研究中心

• 批准号: 10394109
• 负责人: Lance A Waller
• 金额: $ 30.5万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-05-21 至 2027-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10394109
• 关键词: Affect; Behavior; Bioinformatics; Biometry; Characteristics; Collaborations; Communities; Complement; Connective Tissue; Consult; Core Facility; Cost Sharing; Custom; Data; Data Analyses; Data Analytics; Data Collection; Data Element; Data Science; Data Science Core; Data Scientist; Data Set; Data Sources; Disease; Educational workshop; Elements; Environmental Health; Foundations; Funding; Future; Generations; Genomics; Goals; Health; Health Sciences; Human; Immersion; Incubated; Individual; Informatics; Infrastructure; Knowledge; Learning; Link; Machine Learning; Measurable; Measurement; Methods; Mind; Mission; Modeling; Monitor; National Institute of Environmental Health Sciences; Outcome; Personal Satisfaction; Pilot Projects; Policies; Policy Maker; Postdoctoral Fellow; Proteomics; Recording of previous events; Reproducibility; Research; Research Personnel; Research Project Grants; Science; Scientist; Software Tools; Source; Students; Systems Biology; Techniques; Time; Training; Translating; Translational Research; analytical tool; archive data; archived data; base; built environment; career; citizen science; community based participatory research; community engagement; community partnership; community setting; computerized tools; data communication; data management; data pipeline; data repository; data sharing; data standards; design; diverse data; experience; field study; graduate student; improved; innovation; insight; mathematical model; member; metabolomics; multiple data types; next generation; novel; operation; programs; remote sensing; response; science teacher; statistical and machine learning; success; tool; training opportunity; transcriptomics; trend

HERCULES: ENVIRONMENTAL HEALTH DATA SCIENCE CORE – SUMMARY Partnering with HERCULES Cores that define and apply (Community Engagement Core, CEC), innovate (Pilot Project Program, PPP), operationalize (Integrated Health Sciences Facility Core (IHSFC), and coordinate and evaluate (Administrative Core), the Environmental Health Data Sciences Core (EHDSC) functions to enable and interpret translational research on the exposome. Specifically, the EHDSC will: 1) Develop and support data pipelines linking the wide range of HERCULES Members’ datasets to projects large and small (Aim 1); 2) Advance expanded and customized data management and analysis plans, implement novel analytic approaches, and expand the HERCULES data and analytic infrastructure (Aim 2); and 3) Provide in-depth introductions and training sessions for HERCULES Members and partners focusing on data science principles, statistical and machine learning design and analysis, and analytic modeling tools of computational systems biology (Aim 3). All three functions are essential to translate exposome-related data of different measurement types taken from different places at different times into informative, interpretable, and communicable results for community members, stakeholders, researchers, and policy makers. Building on a connected collaborative network between our experienced data science professionals and HERCULES Members and community partners, the EHDSC will 1) provide the Administrative Core with insight into existing and emerging trends in data management and analysis from inside and outside the HERCULES community in order to assure training of all Members and support for new and early career investigators; 2) collaborate directly with the CEC in working with HERCULES community partners to identify relevant existing data sources, partnerships with HERCULES Members, and/or support citizen science efforts to provide data collection, data management, and data communication plans; 3) partner with the IHFSC to link health outcomes and exposure measurements in innovative ways quantifying, operationalizing, and interpreting exposome data within translational environmental health research; 4) accelerate the innovative research of the Pilot Program by providing needed support across a range of data science needs. Taken together, the EHDSC provides clear connections to all elements of HERCULES and complements the Administrative Core, the CEC, the Pilot Program, and the IHSFC through close collaboration in our overall mission of learning how the exposome affects health and community well-being and using that knowledge to improve human health.

HERCULES：环境健康数据科学核心 – 摘要 与定义和应用（社区参与核心、CEC）、创新（试点）的 HERCULES 核心合作 项目计划，PPP），实施（综合健康科学设施核心（IHSFC），并协调和 评估（管理核心），环境健康数据科学核心（EHDSC）功能，以实现 具体来说，EHDSC 将： 1) 开发和支持暴露组的转化研究。 将各种 HERCULES 成员的数据集与大大小小的项目连接起来的数据管道（目标 1）； 推进扩展和定制的数据管理和分析计划，实施新颖的分析 方法，并扩展 HERCULES 数据和分析基础设施（目标 2）；以及 3）提供深入的 针对 HERCULES 会员和合作伙伴的介绍和培训课程，重点关注数据科学原理， 统计和机器学习设计和分析，以及计算系统的分析建模工具 生物学（目标 3）对于转换不同测量的暴露组相关数据至关重要。 将不同时间、不同地点的类型转化为信息丰富、可解释且可交流的结果 社区成员、利益相关者、研究人员和政策制定者建立在相互联系的协作基础上。 我们经验丰富的数据科学专业人员与 HERCULES 会员和社区之间的网络 合作伙伴，EHDSC 将 1) 为管理核心提供对现有和新兴趋势的洞察 来自 HERCULES 社区内外的数据管理和分析，以确保培训 所有会员的意见以及对新晋职业研究者的支持；2) 直接与 CEC 合作 与 HERCULES 社区合作伙伴合作，确定相关的现有数据源、合作伙伴关系 HERCULES 成员和/或支持公民科学工作，以提供数据收集、数据管理和 数据沟通计划；3) 与 IHFSC 合作，将健康结果和暴露测量联系起来 在转化过程中量化、操作和解释暴露组数据的创新方法 环境健康研究；4）通过提供 综上所述，EHDC 提供了明确的数据科学需求支持。 连接到 HERCULES 的所有元素，并补充了管理核心、CEC、Pilot 计划和 IHSFC 通过密切合作完成我们的总体使命：了解暴露组如何 影响健康和社区福祉，并利用这些知识来改善人类健康。