UC Denver Diabetes Research Center

加州大学丹佛分校糖尿病研究中心

• 批准号: 10392976
• 负责人: LORI SUSSEL
• 金额: $ 134.43万
• 依托单位: UNIVERSITY OF COLORADO DENVER
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-04-01 至 2025-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10392976
• 关键词: Area; Autoimmunity; Biomedical Research; Budgets; Cell Culture Techniques; Cells; Clinical; Clinical Research; Clinical Skills; Collaborations; Colorado; Communities; Complex; Complications of Diabetes Mellitus; Data; Databases; Development; Diabetes Mellitus; Direct Costs; Disease; Doctor of Philosophy; Education; Environment; Etiology; Faculty; Flow Cytometry; Fostering; Genes; Goals; Grant; Growth; Histology; Hospitals; Human; Immunologics; In Vitro; Individual; Infrastructure; Institutes; Insulin-Dependent Diabetes Mellitus; Knowledge; Medical; Mentors; Microscopy; Modeling; Non-Insulin-Dependent Diabetes Mellitus; Operations Research; Organoids; Participant; Patients; Pediatric Hospitals; Prevention; Reagent; Research; Research Personnel; Resource Sharing; Resources; Rodent; Sampling; Scientist; Series; Services; Technology; Tissue Procurements; Tissues; Training; Translations; United States National Institutes of Health; Universities; University Hospitals; base; career; career development; cost; design; diabetes mellitus therapy; human stem cells; improved; innovation; instrumentation; islet; medical schools; member; novel; programs; recruit; tissue processing

CENTER OVERVIEW PROJECT SUMMARY/ABSTRACT The University of Colorado Denver (UC Denver) is world renowned for basic, translational, and clinical diabetes research and treatment of both Type 1 and Type 2 diabetes (T1D and T2D), and their related complications. The proposed University of Colorado Diabetes Research Center (UC Denver DRC) will strengthen diabetes research in Colorado by providing: 1) state-of-the-art research technologies and specialized resources to maximize effective and innovative research; 2) access to patient samples and data; 3) enrichment programs, education and seminar series to the diabetes community; and 4) by attracting new scientists into the diabetes field through the Pilot and Feasibility program. These objectives will be realized by providing improved infrastructure and access to specialized reagents and resources, and an environment that promotes scientific interactions, research discoveries, and progress towards diabetes treatment and cures. The UC Denver DRC will be primarily located on the rapidly growing Anschutz Medical Campus (AMC) in Aurora, Colorado where the majority of the UC Denver clinical and research departments are located. This unique multi-hospital and academic campus configuration allows for a broad diabetes research base, which currently includes 88 basic, translational, and clinical scientific investigators across 17 departments and divisions at UC AMC who currently bring diabetes/diabetes-related direct cost grant support totaling > $65 million in individual grants and >$14 million in center and training grants. Drs. Lori Sussel, PhD. and Jane Reusch, MD bring together complementary areas of scientific backgrounds and expertise to oversee the organization and scientific focus of the UC Denver DRC. We will implement four Biomedical Research Cores to provide cutting-edge technologies in Clinical Resources (fully integrated databases for tracking of study participants, bio-samples and data), Tissue Procurement and Processing (rodent tissue and islet isolation, human islet and tissue procurement, histology services, cell culture bank), Diabetes Modeling (human stem cell-derived in vitro cell and organoid models, gene editing), and Cell and Tissue Analysis (advanced microscopy, flow cytometry, specialized CyTOF and MIBI reagents for the diabetes community). The UC Denver DRC will also establish a Pilot and Feasibility Program to recruit young faculty into diabetes and diabetes-related research, and encourage established investigators from other fields to enter the diabetes field. The Dean of the UC Denver School of Medicine has pledged to supplement the P&F budget by $100,000 each year to promote an increased diabetes research presence on campus. Finally, the UC Denver DRC Enrichment Program will promote the interaction between diabetes researchers at UC AMC by providing seminar forums for exchange of research findings, providing opportunities to form collaborative relationships, and encouraging cross-pollination between the diverse diabetes communities.

中心概述 项目摘要/摘要 科罗拉多大学丹佛分校（UC丹佛大学）以基本，转化和临床糖尿病而闻名 1型和2型糖尿病（T1D和T2D）及其相关并发症的研究和治疗。这 拟议的科罗拉多大学糖尿病研究中心（UC Denver DRC）将加强糖尿病研究 在科罗拉多州提供：1）最先进的研究技术和专业资源以最大化 有效和创新的研究； 2）获取患者样品和数据； 3）丰富计划，教育 和糖尿病社区的研讨会系列； 4）通过吸引新科学家进入糖尿病领域 飞行员和可行性计划。这些目标将通过提供改进的基础架构和 获取专门的试剂和资源，以及促进科学互动的环境，研究 发现，以及朝着糖尿病治疗和治疗方法发展。加州大学丹佛分校刚果民主共和国将主要位于 在科罗拉多州奥罗拉（Aurora）的快速生长的Anschutz医疗校园（AMC）上 丹佛临床和研究部门已找到。这个独特的多医院和学术校园 配置允许建立广泛的糖尿病研究基础，目前包括88个基本，翻译和 UC AMC的17个部门的临床科学研究人员目前带来 糖尿病/糖尿病相关的直接费用赠款支持总计> 6500万美元的个人赠款，> 14美元 百万美元和培训补助金。博士。洛里·苏塞尔（Lori Sussel）博士。以及医学博士简·雷斯（Jane Reusch） 科学背景和专业知识的互补领域，以监督组织和科学重点 加州大学丹佛分校。我们将实施四个生物医学研究核心，以提供最先进的技术 在临床资源（用于跟踪研究参与者，生物样本和数据的完全集成数据库）中， 组织采购和加工（啮齿动物组织和胰岛分离，人类胰岛和组织采购， 组织学服务，细胞培养库），糖尿病建模（人类干细胞衍生的体外细胞和类器官 模型，基因编辑）以及细胞和组织分析（高级显微镜，流式细胞仪，专业 糖尿病社区的细胞和MIBI试剂）。加州大学丹佛分校刚果民主共和国还将建立一个飞行员， 可行性计划，招募年轻教师参加糖尿病和与糖尿病有关的研究，并鼓励 来自其他领域的研究人员进入糖尿病领域。加州大学丹佛分校学校的院长 医学已承诺每年增加100,000美元的预算，以促进增加的糖尿病 在校园内的研究。最后，UC丹佛DRC富集计划将促进互动 在UC AMC的糖尿病研究人员之间，通过提供研讨会论坛来交换研究结果， 提供建立协作关系的机会，并鼓励 多样化的糖尿病社区。