Integrated Health Sciences Facility Core

综合健康科学设施核心

• 批准号: 10393299
• 负责人: Debra MacKenzie
• 金额: $ 18.31万
• 依托单位: UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-08-25 至 2026-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10393299
• 关键词: Address; Animals; Basic Science; Biological; Cancer Biology; Cardiovascular Diseases; Clinical; Collaborations; Communicable Diseases; Communication; Communities; Community Health; Complex; Consultations; Core Facility; DNA Repair; Data; Ensure; Environmental Exposure; Environmental Health; Environmental Science; Epidemiology; Gases; Goals; Health; Health Policy; Health Sciences; Human; Immunology; Individual; Infrastructure; Institutional Review Boards; Knowledge; Laboratories; Metal exposure; Metals; Mexico; Mining; Molecular Toxicology; National Institute of Environmental Health Sciences; New Mexico; Nutritional Science; Oils; Outcome; Pharmacologic Substance; Population; Predisposition; PubMed; Public Health; Publications; Research; Research Design; Research Personnel; Research Support; Resources; Respiratory Disease; Risk Factors; Sampling; Science; Services; Site; Source; Toxicology; Translational Research; Uranium; Work; base; commune; design; experience; hydraulic fracturing; innovation; instrumentation; interest; member; metabolomics; neurodevelopment; programs; research study; response; text searching; translational research program; translational study; tribal community; wasting

IHSFC PROJECT SUMMARY Within the state of New Mexico, the health impacts (both individual and communal) from mining, metal exposure as well as oil/gas/fracking activities are of considerable community concern. There is a broad range of experience and extensive depth of knowledge that exists among the researchers and research teams throughout the NM-INSPIRES Center investigators that can be directed toward addressing these community environmental health concerns. The overall goal of the IHSFC is to work in partnership with all the Center’s Cores and provide key infrastructure and support to actualize innovative translational and reverse translational environmental health research that serves the communities of New Mexico. Environmental health research currently conducted by NM-INSPIRES investigators generates data on a large number of variables including environmental exposures, intermediate biological responses, and complex health outcomes. The findings from this broad array of ongoing environmental, human and animal studies provides a rich source of data to inform and inspire new translational or reverse-translational studies addressing complex exposure-outcome relationships. The IHSFC will support the expansion and implementation of new translational and reverse-translational research and capitalizes on the broad experience that exists within the Center. The IHSFC team includes expertise in epidemiology, public health and toxicology to provide guidance for study design to effectively address population risk factors and susceptibilities as well as potential mechanisms that drive health outcomes. Specifically, the IHSFC will provide exceptional and complementary scientific, technical and operational support to facilitate both new collaborations and initiatives through 1) providing support for study design and implementation of population, clinical and laboratory based studies, 2) overcoming institutional or regulatory bottlenecks, 3) facilitating access to existing data and samples from ongoing environmental research to support or validate new initiatives. The specific experience within the IHSFC team in implementing translational research studies will provide an infrastructure that does not currently exist across the Center. The IHSFC will work to capitalize on the unique research background and experience within the NM INSPIRES Center to expand our reach more broadly across New Mexico and build on the strength of existing expertise, available resources to develop the infrastructure and create a value- added synergistic service that will achieve Center objectives. The services and support provided by the IHSFC provides a mechanism to continue to expand our excellent basic and translational research programs in environmental health to serve our diverse community.

IHSFC 项目摘要 在新墨西哥州，采矿、金属开采对健康（个人和社区）的影响 暴露以及石油/天然气/水力压裂活动引起了广泛的社会关注。 研究人员和研究团队中存在的经验和广泛的知识深度 整个 NM-INSPIRES 中心的调查人员可以针对这些社区进行指导 IHSFC 的总体目标是与中心的所有成员合作。 核心并提供关键基础设施和支持，以实现创新的转化和逆向 为新墨西哥州环境社区服务的转化环境健康研究。 NM-INSPIRES 研究人员目前进行的健康研究产生了大量数据 变量包括环境暴露、中间生物反应和复杂的健康状况 一系列正在进行的环境、人类和动物研究的结果提供了一个结果。 丰富的数据源可以为解决复杂问题的新的转化或逆翻译研究提供信息和启发 IHSFC 将支持新措施的扩展和实施。 翻译和逆翻译研究，并利用现有的广泛经验 IHSFC 团队拥有流行病学、公共卫生和毒理学方面的专业知识，可提供指导。 用于研究设计以有效解决人群风险因素和敏感性以及潜在风险 具体而言，IHSFC 将提供特殊且互补的机制。 科学、技术和运营支持，通过以下方式促进新的合作和举措：1) 为人口、临床和实验室研究的研究设计和实施提供支持，2) 克服制度或监管瓶颈，3）促进获取现有数据和样本 正在进行的环境研究，以支持或验证新举措的具体经验。 IHSFC 团队在实施转化研究时将提供一个基础设施， IHSFC 将致力于利用该中心独特的研究背景和优势。 NM INSPIRES 中心的经验，以扩大我们在新墨西哥州更广泛的影响力，并建立 凭借现有的专业知识和可用资源来开发基础设施并创造价值 增加协同服务，以实现中心的目标。 IHSFC 提供了一种机制来继续扩展我们优秀的基础和转化研究项目 致力于环境健康，为我们多元化的社区服务。