PROSPECT: Puerto Rico Observational Study of Psychosocial, Environmental, and Chronic Disease Trends

前景：波多黎各社会心理、环境和慢性病趋势观察研究

• 批准号: 10393805
• 负责人: JOSIEMER MATTEI
• 金额: $ 13.85万
• 依托单位: HARVARD SCHOOL OF PUBLIC HEALTH
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-07-01 至 2022-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10393805
• 关键词: Administrative Supplement; Adult; Age; Biological Markers; Blood Glucose; Blood Pressure; Blood specimen; Boston; Calcium; Chronic Disease; Clinical; Clinical Trials; Data; Diabetes Mellitus; Diastolic blood pressure; Diet; Dietary Supplementation; Dietary intake; Disease; Dose; Ethnic Origin; Food; Frequencies; Glucose; Glycosylated hemoglobin A; Goals; Health; High Prevalence; Hypertension; Incidence; Individual; Infrastructure; Insulin; Insulin Resistance; Intake; Intervention; Island; Knowledge; Link; Magnesium; Measures; Mg supplementation; Micronutrients; Minerals; Multivitamin; Non-Insulin-Dependent Diabetes Mellitus; Not Hispanic or Latino; Nutrient; Observational Study; Participant; Patient Recruitments; Pattern; Physiological; Placebos; Plasma; Policies; Population; Potassium; Prediabetes syndrome; Prevalence; Psychosocial Assessment and Care; Public Health; Puerto Rican; Puerto Rico; Questionnaires; Recommendation; Reporting; Role; Seminal; Serum; Sodium; Supplementation; Underserved Population; United States; Vitamin B 12; Vitamin B6; Vitamin D; Vitamin D supplementation; Vitamins; blood pressure reduction; cardiometabolism; cohort; diabetes risk; dietary; dietary guidelines; dietary supplements; disorder prevention; disparity reduction; epidemiology study; good diet; high risk; improved; prevent; programs; recruit; sex; trend

Project Summary In 2019, the United States (US) territory of Puerto Rico (PR) had the highest prevalence of type 2 diabetes and disparately higher hypertension prevalence compared to the US population. Strong evidence supports that these cardiometabolic conditions can be prevented with a healthy diet. However, we have documented suboptimal diet quality and inadequate age- and sex-specific intake for magnesium (Mg), calcium (Ca), potassium (K), and vitamin D (vitD) among adults in PR. Dietary supplementation may significantly lower the inadequacy of several nutrients; however, our preliminary data among adults in PR suggest moderate-to-low use of dietary supplements. Importantly, dietary supplement use may alter serum concentration of micronutrients, creating the need to determine correlation of intake with physiological status. Data on supplement use are scarce for PR, and it remains unknown why they choose to use supplements, patterns of use including frequency and dose, and how these are associated with physiological status as well as with hypertension and diabetes, as evidence suggests selected nutrients may help prevent these conditions. Our overall goal is to identify use of dietary supplements which may relate to current cardiometabolic conditions, and inform dietary guidelines and future research needs aimed at reducing cardiometabolic disparities in PR. We will leverage the established infrastructure of PROSPECT: Puerto Rico Observational Study of Psychosocial, Environmental, and Chronic disease Trends', a cohort of adults (30-75y) conducted across the island. We administer a validated food frequency questionnaire with some questions on supplement use, measure blood pressure, and analyze glucose markers from blood samples. Our proposal directly responds to this Administrative Supplement by adding a comprehensive supplement use questionnaire for analysis of association with blood pressure and diabetes markers, and analysis of serum Mg, vitD, vitB6, and vitB12 for correlation with supplement use, in the next 1,000 recruited participants. Our specific aims are to (1) estimate prevalence of use, frequency, duration, dose, and reasons for using dietary supplements using a questionnaire; (2) determine correlation between intake from supplement use of selected vitamins and minerals with serum biomarkers; and (3) determine associations between dietary use of supplements for Mg, vitD, vit6 and vitB12 and blood pressure and diabetes markers (i.e., plasma glucose, insulin, HOMA-IR, and hemoglobin A1c). This study will identify use of dietary supplements in PR – especially those linked to cardiometabolic conditions – to inform tailored public health messages and programs to effectively improve cardiometabolic health. The newly collected data will generate knowledge on how and why adults use dietary supplements, and which nutrient supplements may contribute to cardiometabolic health, and be possible targets for interventions, policies, or clinical recommendations with the goal of reducing cardiometabolic disparities.

项目摘要 2019年，美国（美国）波多黎各领土（PR）的患病率最高 与美国人口相比，高血压患病率更高。有力的证据支持 这些心脏代谢条件可以通过健康的饮食来预防。但是，我们已经记录了 镁（MG），钙（CA），钙特异性摄入量的饮食质量和不足的年龄和性别特异性摄入量（CA）， PR中的成年人中的钾（K）和维生素D（VITD）。补充饮食可能会大大降低 几种营养素不足；但是，我们在公关中成年人中的初步数据表明现代化 使用饮食补充剂。重要的是，饮食补充剂的使用可能会改变血清浓度 微量营养素，创造了确定摄入量与身体状况相关的需求。数据上 PR的补充使用稀缺，尚不清楚为什么他们选择使用补充剂，模式 使用包括频率和剂量，以及它们与身体状况以及 高血压和糖尿病，正如证据表明所选营养素可能有助于预防这些疾病的情况。 我们的总体目标是确定可能与当前心脏代谢有关的饮食补充剂的使用 条件，并告知饮食指南和未来的研究需求，旨在减少心脏代谢 公关的差异。我们将利用既定的前景基础设施：波多黎各观察 进行社会心理，环境和慢性病趋势的研究，成年人（30-75Y） 在整个岛上。我们管理经过验证的食品频率问卷，并提供一些有关补充的问题 使用，测量血压并分析来自血液样本的葡萄糖标记。我们的建议直接回应 通过添加全面补充的使用调查表来分析这种行政补充 与血压和糖尿病标记的关联，以及血清MG，VITD，VITB6和VITB12的分析 在接下来的1,000名招募参与者中，与补充使用的相关性。我们的具体目的是（1）估算 使用，频率，持续时间，剂量和使用问卷使用饮食补充剂的原因； （2）确定摄入量的相关性，从补充选择的维生素和矿物质的使用 生物标志物； （3）确定补充剂用于MG，VITD，VIT6和VITB12之间的关联 以及血压和糖尿病标记（即等离子体葡萄糖，胰岛素，HOMA-IR和血红蛋白A1C）。 这项研究将确定PR中饮食补充剂的使用 - 尤其是与心脏代谢相关的补充剂 条件 - 告知量身定制的公共卫生消息和计划以有效改善心脏代谢 健康。新收集的数据将产生有关成年人如何以及为什么使用饮食补充剂的知识，以及 哪种营养补充剂可能有助于心脏代谢健康，并可能成为 干预措施，政策或临床建议，目的是减少心脏代谢差异。