Understanding how alcohol use affects adolescent COVID-19 acquisition and disease course overtime

了解饮酒如何影响青少年 COVID-19 感染和病程

• 批准号: 10393439
• 负责人: Michele L. Ybarra
• 金额: $ 33万
• 依托单位: CENTER FOR INNOVATIVE PUBLIC HEALTH RESEARCH
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-21 至 2024-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10393439
• 关键词: 17 year old; 18 year old; Address; Adolescent; Adolescent Risk Behavior; Affect; African American; Alcohol consumption; Alcohols; COVID-19; COVID-19 pandemic; Cessation of life; Consumption; Data; Development; Disease; Ensure; Family; Frequencies; Future; Health; Health Policy; Hispanics; Home; Incidence; Intervention; Lead; Length; Life; Life Cycle Stages; Longitudinal trends; Mental Health; Minority; Nature; Outcome; Outcome Measure; Pattern; Population; Procedures; Public Health; Quarantine; Reporting; Research; Resources; Risk; Risk Behaviors; Risk Factors; SARS-CoV-2 negative; SARS-CoV-2 positive; School-Age Population; Schools; Severities; Severity of illness; Sexual and Gender Minorities; Sexual and Gender Minority Youth; Social Distance; Surveys; Symptoms; Testing; Time; Virus; Youth; alcohol use disorder; base; binge drinking; coping; coronavirus disease; empowered; ethnic minority population; expedited review; experience; gender minority; health disparity; health inequalities; high school; immune system function; longitudinal analysis; pandemic disease; poor sleep; prospective; racial minority; recruit; response; sexual minority; sleep pattern; social; social media; stressor; theories; underage drinking; vulnerable adolescent; 17 year old; 18 year old; Address; Adolescent; Adolescent Risk Behavior; Affect; African American; Alcohol consumption; Alcohols; COVID-19; COVID-19 pandemic; Cessation of life; Consumption; Data; Development; Disease; Ensure; Family; Frequencies; Future; Health; Health Policy; Hispanics; Home; Incidence; Intervention; Lead; Length; Life; Life Cycle Stages; Longitudinal trends; Mental Health; Minority; Nature; Outcome; Outcome Measure; Pattern; Population; Procedures; Public Health; Quarantine; Reporting; Research; Resources; Risk; Risk Behaviors; Risk Factors; SARS-CoV-2 negative; SARS-CoV-2 positive; School-Age Population; Schools; Severities; Severity of illness; Sexual and Gender Minorities; Sexual and Gender Minority Youth; Social Distance; Surveys; Symptoms; Testing; Time; Virus; Youth; alcohol use disorder; base; binge drinking; coping; coronavirus disease; empowered; ethnic minority population; expedited review; experience; gender minority; health disparity; health inequalities; high school; immune system function; longitudinal analysis; pandemic disease; poor sleep; prospective; racial minority; recruit; response; sexual minority; sleep pattern; social; social media; stressor; theories; underage drinking; vulnerable adolescent

One in six 14-17 year-olds (16.3%) have tested positive for COVID-19. Understanding the factors that confer increased risk is imperative given adolescents’ vulnerable developmental stage. One particularly salient risk factor may be alcohol use, both because intense alcohol use negatively impacts immune system functioning and sleep patterns, and also because consuming alcohol with others could lead to lowered inhibitions that result in reduced social distancing. COVID-19 also may be impacting the way in which adolescents consume alcohol, potentially with life-long consequences. Understanding how pandemic experiences have affected the frequency and intensity of alcohol use is necessary for ensuring sufficient treatment supports for youth. It also is crucial to know how alcohol may affect the COVID-19 disease course, including the severity and long-term impact on somatic and mental health. The pandemic also has reified long-standing health inequities. Indeed, data overwhelming suggest that Black/African American and Hispanic people are significantly more likely to acquire COVID-19, and to have a worse disease course. The same is true for people who identify as a sexual and gender minority (SGM). Before the pandemic, high school-aged SGM youth reported higher rates of alcohol use than non-SGM youth, whereas rates were similar for Hispanic and White youth and significantly lower for Black/African American youth. Ensuring that we understand how pandemic experiences and alcohol together may be conferring risk similarly and differently for these minority adolescent populations is fundamental to addressing disparities. In response to RFA-AA-21-002, we propose to recruit and survey 2,500 14-18 year-olds, 500 of whom will have tested positive for COVID-19 in the past 3 months and 2,000 of whom will have never tested positive for COVID-19. Using procedures successfully implemented by the research team previously, adolescents will be recruited on social media and surveyed online. This will afford a national scope while empowering youth to engage in this sensitive survey topic where and when it is safe for them. Youth who have tested positive for COVID-19 at baseline will be asked to retrospectively report their disease severity, progression, and outcomes, as well as their current COVID-19-related symptoms. Both youth who have been positive and those who are negative for COVID-19 will provide information about their past and current alcohol use, as well as past and current COVID-protective and -risk behaviors. All youth then will be prospectively followed for 24 months. They will complete comprehensive online surveys at 6-, 12-, 18- and 24-months, and brief, monthly surveys that query the key exposures and outcomes in the in-between months. Our main exposures will be 1) alcohol use in the past 30 days, 2) binge drinking in the past 30 days, and 3) alcohol use disorder. Our main outcome measures will be: 1) COVID-19 acquisition; 2) the extent of and 3) length to which symptoms are experienced. Findings will have both short- and long-term impact on the public health response to this and future pandemics.

六分之一的14-17岁（16.3％）的Covid-19测试呈阳性。了解会议的因素 考虑到青少年脆弱的发展阶段，必须增加风险。一个特别明显的风险 因素可能是饮酒，这既是因为强烈的酒精使用对免疫系统的功能负面影响 和睡眠方式，也是因为与他人一起喝酒可能会导致抑制作用降低 导致社会距离减少。 COVID-19也可能影响青少年消费的方式 酒精，可能带有终身后果。了解大流行经历如何影响 为了确保对青年的足够治疗支持，必须使用饮酒的频率和强度。也是如此 知道酒精如何影响199疾病病程至关重要，包括严重程度和长期 对躯体和心理健康的影响。 大流行还弥补了长期的健康不平等。确实，数据压倒性的表明 黑人/非洲裔美国人和西班牙裔人更有可能获得Covid-19，并且有一个 疾病病程更糟。对于认同性别和性别少数群体（SGM）的人来说，情况也是如此。 在大流行之前，高中生的SGM青年报告的酒精使用率比非SGM青年更高， 而西班牙裔和白人青年的比率相似，而黑人/非裔美国人的比率则明显降低 青年。确保我们了解大流行的经历和酒精如何成为会议风险 对于这些少数族裔人群而言，类似地和不同的方式是解决分布的基础。 为了响应RFA-AA-21-002，我们建议招募和调查2,500名14-18岁，其中500名将 在过去的3个月中，Covid-19的Covid-19测试呈阳性，其中2,000人从未对 新冠肺炎。使用以前研究团队成功实施的程序，青少年将是 在社交媒体上招募并在线调查。这将负担全国范围，同时使青年有能力 参与这个敏感的调查主题，何时何地对他们安全。测试阳性的年轻人 Covid-19时将要求回顾性地报告其疾病的严重程度，进展和结果， 以及他们目前的共证症状。都是积极的年轻人和那些 COVID-19的否定将提供有关其过去和当前饮酒以及过去和过去和过去和过去的信息 当前的互联保护和 - 风险行为。然后，所有青年都将被期望遵循24个月。他们 将在6、12、18和24个月完成全面的在线调查，并进行简短的每月调查 查询在几个月内的关键暴露和结果。我们的主要风险将是1） 过去30天，2）在过去的30天内暴饮暴食，以及3）酒精疾病。我们的主要结果 措施将是：1）共同收购； 2）范围和3）经历符号的长度。 调查结果将对公共卫生对此大流行的反应产生短期和长期影响。