Proteomics Shared Resource

蛋白质组学共享资源

• 批准号: 10380706
• 负责人: MARK R CHANCE
• 金额: $ 12.99万
• 依托单位: CASE WESTERN RESERVE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-08-01 至 2023-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10380706
• 关键词: Accounting; Applications Grants; Award; Bioinformatics; Biological; Budgets; Cancer Center Support Grant; Cells; Clinic; Clinical; Communication; Complement; Comprehensive Cancer Center; Consultations; Data; Data Analyses; Data Set; Developmental Therapeutics Program; Doctor of Philosophy; Drug Kinetics; Equipment; Experimental Designs; Funding; Grant; Human Resources; Journals; Malignant Neoplasms; Malignant neoplasm of gastrointestinal tract; Manuscripts; Medical; Mission; Molecular Medicine; NCI Center for Cancer Research; Nature; Paper; Pathway interactions; Professional Education; Proteomics; Proteomics Shared Resource; Publishing; Research; Research Institute; Research Personnel; Resource Sharing; Resources; Science; Services; Site; System; Systems Biology; Techniques; Technology; Training; Universities; anticancer research; bioinformatics resource; bioinformatics tool; cancer genetics; cancer pharmacology; clinical investigation; computing resources; experimental study; imaging system; instrument; investigator training; lipidomics; medical schools; member; metabolomics; molecular oncology; new technology; nutrition; phosphoproteomics; professor; programs; small molecule; structural biology; tool

PROTEOMICS SHARED RESOURCE PROJECT SUMMARY/ABSTRACT The Proteomics Shared Resource (Proteomics SR) is an essential asset to Case Comprehensive Cancer Center (Case CCC) members' research, illustrated by the breadth of scientific program involvement and reflected in the large number of investigators who use this SR. Last year alone, over 120 investigators, 35% of whom were Case CCC members, accounting for 44% of total usage, from all 7 of the Case CCC Programs used the SR. The mission of the Proteomics SR is to provide advanced proteomic and metabolomic technologies and small- molecule analysis, especially for pharmacokinetic (PK) studies, via state-of-the-art instruments, computational resources, and trained staff, to support clinical, translational, and structural biology research. The Specific Aims of the Proteomics SR are to: 1) Provide advanced proteomic and metabolomics technologies and instrument resources to solve unmet needs in cancer research. 2) Develop and apply systems biology tools to solve challenges in analysis and integration of large ‘omics’ datasets. 3) Provide professional education, consultation and training to Case CCC members. At last review, the Proteomics SR was rated Exceptional merit. Throughout the current funding cycle (2012- 2016), the Proteomics SR provided services to 268 registered users, 83 (31%) of whom are Case CCC members, representing all 7 of the Case CCC programs. The Proteomics SR continues to attract new users, and to provide multiple sophisticated proteomic techniques and technique-specific training to investigators' cancer-related projects. The SR has also developed new technologies and bioinformatics tools that directly facilitate Case CCC members' research, including a global metabolomic and lipidomic platform that will complement both targeted metabolomics and global proteomic experiments. The Proteomics SR consists of two sites; the first site was established at the Cleveland Clinic (CC) Lerner Research Institute (LRI) in 1999 and the second site, the Center for Proteomics & Bioinformatics (CPB) at Case Western Reserve University (CWRU) in 2005. This multi-site Shared Resource, jointly supported and managed by the Case CCC, the CWRU School of Medicine (SOM) and CC, provides access to a full spectrum of proteomic and metabolomic technologies. The services of the Proteomics SR are essential for enhancing the quality of the science in the Case Comprehensive Cancer Center.

蛋白质组学共享资源 项目概要/摘要 蛋白质组学共享资源 (Proteomics SR) 是凯斯综合癌症中心的重要资产 （案例 CCC）成员的研究，通过科学计划参与的广度来说明并反映在 使用此 SR 的调查人员数量众多，仅去年一年就有超过 120 名调查人员，其中 35% 是 Case。 所有 7 个案例 CCC 计划中的 CCC 成员均使用 SR，占总使用量的 44%。 蛋白质组学 SR 的使命是提供先进的蛋白质组学和代谢组学技术以及小 分子分析，特别是药代动力学 (PK) 研究，通过最先进的仪器、计算 资源和训练有素的工作人员，以支持临床、转化和结构生物学研究。 蛋白质组学 SR 的目标是： 1）提供先进的蛋白质组学和代谢组学技术和仪器资源，解决未满足的问题 癌症研究的需求。 2）开发和应用系统生物学工具来解决大型“组学”分析和整合的挑战 数据集。 3）为Case CCC会员提供专业教育、咨询和培训。 在上次审查中，蛋白质组学 SR 在整个资助周期（2012 年至今）被评为“卓越”。 2016），Proteomics SR 为 268 名注册用户提供服务，其中 83 名（31%）为 Case CCC 成员，代表所有 7 个 Case CCC 项目。 Proteomics SR 不断吸引新用户，并提供多种复杂的蛋白质组技术 SR 还开发了新的研究人员癌症相关项目的技术培训。 直接促进 Case CCC 成员研究的技术和生物信息学工具，包括全球 代谢组学和脂质组学平台将补充靶向代谢组学和全球蛋白质组学 蛋白质组学 SR 由两个站点组成；第一个站点位于克利夫兰诊所 (CC)。 1999 年勒纳研究所 (LRI) 和第二个站点，蛋白质组学和生物信息学中心 (CPB) 2005 年在凯斯西储大学 (CWRU) 获得该学位。这个多站点共享资源由共同支持和 由 Case CCC、CWRU 医学院 (SOM) 和 CC 管理，提供全方位的服务 蛋白质组学和代谢组学技术的服务对于增强蛋白质组学和代谢组学技术至关重要。 凯斯综合癌症中心的科学质量。