Maternal and Infant Environmental Health Riskscape (MIEHR) Research Center

母婴环境健康风险景观（MIEHR）研究中心

• 批准号: 10376060
• 负责人: ELAINE SYMANSKI
• 金额: $ 142.77万
• 依托单位: BAYLOR COLLEGE OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-07-16 至 2025-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10376060
• 关键词: Affect; African American; Area; Aromatic Polycyclic Hydrocarbons; Awareness; Biological; Biological Specimen Banks; Chemicals; Child; Cities; Collaborations; Communities; Complex; Data; Databases; Development; Disasters; Diverse Workforce; Environmental Epidemiology; Environmental Exposure; Environmental Health; Environmental Impact; Epidemiology; Ethnic group; Fetal health; Fire - disasters; Fostering; Future; Goals; Hazardous Waste Sites; Health; Health Disparities Research; Historically Black Colleges and Universities; Hurricane; Hypertension; Individual; Industrialization; Infant; Infant Health; Institution; Knowledge; Leadership; Life; Maternal Health; Medicine; Metals; Mothers; Natural Disasters; Neighborhoods; Not Hispanic or Latino; Outcome; Perinatal; Physical environment; Pollution; Population; Positioning Attribute; Pregnancy; Pregnant Women; Premature Birth; Race; Research; Research Activity; Research Personnel; Research Project Grants; Resources; Risk; Role; Sampling; Second Pregnancy Trimester; Social Environment; System; Talents; Testing; Texas; Third Pregnancy Trimester; Universities; Woman; base; built environment; career development; college; community engagement; deprivation; environmental disparity; environmental health disparity; environmental justice; health disparity; health disparity populations; health literacy; infant morbidity; innovation; interdisciplinary collaboration; low socioeconomic status; maternal morbidity; multi-ethnic; multi-racial; multidisciplinary; next generation; obstetric outcomes; pregnancy disorder; racial and ethnic; racial disparity; racial population; resilience; response; stressor

Despite the knowledge that pregnancy affects the health trajectory of both mother and child across the lifecourse, significant racial disparities exist. African-American (AA) women are at greatest risk for preterm birth and for dying from hypertensive disorders of pregnancy (HDP) than any other group in the U.S. To decipher what drives these disparities, we are proposing a new Environmental Health Disparities Maternal and Infant Environmental Health Riskscape (MIEHR) Research Center. The Goal of the MIEHR Research Center is to elucidate contributions of the biological, physical, social and built environments of the environmental riskscape to environmental health disparities in pregnant women and their infants. The Houston-based MIEHR leverages partnerships and strong institutional support from Baylor College of Medicine and Texas Southern University, the fourth largest historically black university in the U.S. Notably, Houston offers a microcosm for research at the intersection of environmental exposures and health disparities, with its diverse multi-ethnic and multi-racial population and documented environmental injustices. The city has the largest petrochemical complex in the U.S., numerous hazardous waste sites, no zoning and is at risk for natural and industrial disasters. The MIEHR Research Center has two synergistic Research Projects that build on a unique ongoing, perinatal database and biospecimen repository: the BCM Peribank. Project 1: The Environmental Riskscape, Disasters and Obstetric Outcomes will utilize an epidemiologic approach to identify differences in race-specific associations between the mixture of individual chemicals (i.e. polycyclic aromatic hydrocarbons and metals) and place-based stressors in the riskscape and preterm birth. This project will also examine the impact of Hurricane Harvey on racial disparities in these exposures. Project 2: Disparities Aware Classifiers for Maternal and Infant Health will use an “omics” approach to develop and validate disparity aware classifiers for preterm birth and HDP for AA and non-Hispanic White women. The classifiers will be built from data obtained at delivery and the predictive capability of these classifiers will then be tested in second trimester pregnant women. MIEHR activities will be informed by a Community Engagement and Dissemination Core, which will enhance environmental health literacy and capacity for sustainable initiatives that build community resilience. An Investigator Development Core will support innovative pilot research that will promote career development of talented investigators from health disparity populations and increase capacity for future environmental health disparities research. The Administrative Core will provide organizational and integration support for MIEHR investigators, institutions and engaged communities. The MIEHR Research Center will accomplish its goals in research, career development and community engagement with multidisciplinary and diverse teams of community and academic experts, interdisciplinary collaborations between synergistic research projects, activities that develop a diverse workforce and community engagement that fosters equitable community stakeholder interactions.

尽管我们知道怀孕会影响母亲和孩子一生的健康轨迹， 存在显着的种族差异。非洲裔美国 (AA) 妇女早产和早产的风险最大。 在美国，死于妊娠期高血压疾病 (HDP) 的人数比任何其他群体都要高。 针对这些差异，我们提出新的母婴环境健康差异 环境健康风险景观 (MIEHR) 研究中心 MIEHR 研究中心的目标是 阐明生物、物理、社会和建筑环境对环境风险景观的贡献 总部位于休斯敦的 MIEHR 充分利用了孕妇及其婴儿的环境健康差异。 贝勒医学院和德克萨斯南方大学的合作伙伴关系和强有力的机构支持， 美国第四大历史悠久的黑人大学 值得注意的是，休斯顿为以下领域的研究提供了一个缩影 环境暴露与健康差异的交叉，以及其多样化的多民族和多种族 该市拥有美国最大的石化联合体。 美国危险废物处理场众多，没有分区，并且面临自然和工业灾害的风险。 研究中心有两个协同研究项目，它们建立在独特的持续围产期数据库和 生物样本库：BCM Peribank 项目 1：环境风险状况、灾害和风险。 产科结果将利用流行病学方法来确定种族特定关联的差异 单个化学品（即多环芳烃和金属）的混合物与基于地点的混合物之间 该项目还将研究飓风哈维对风险状况和早产的影响。 这些暴露中的种族差异 项目 2：母婴健康差异意识分类器。 将使用“组学”方法来开发和验证早产的差异感知分类器和 HDP AA 和非西班牙裔白人女性将根据分娩时获得的数据和预测数据构建分类器。 这些分类器的能力将在中期妊娠孕妇中进行 MIEHR 活动测试。 由社区参与和传播核心提供信息，这将增强环境健康 培养社区复原力的可持续举措的素养和能力。 核心将支持创新的试点研究，促进来自世界各地的才华横溢的研究人员的职业发展 人口健康差异并提高未来环境健康差异研究的能力。 行政核心将为 MIEHR 调查人员、机构提供组织和整合支持 MIEHR 研究中心将实现其研究、职业目标。 与多学科和多元化的社区和学术团队一起发展和社区参与 专家、协同研究项目之间的跨学科合作、开发多样化的活动 劳动力和社区参与，促进公平的社区利益相关者互动。