Maternal and Infant Environmental Health Riskscape (MIEHR) Research Center

母婴环境健康风险景观（MIEHR）研究中心

• 批准号: 10062083
• 负责人: ELAINE SYMANSKI
• 金额: $ 143.17万
• 依托单位: BAYLOR COLLEGE OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-07-16 至 2025-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10062083
• 关键词: Affect; African American; Area; Aromatic Polycyclic Hydrocarbons; Awareness; Biological; Biological Specimen Banks; Chemicals; Child; Cities; Collaborations; Communities; Complex; Data; Databases; Development; Disasters; Diverse Workforce; Environmental Epidemiology; Environmental Exposure; Environmental Health; Environmental Impact; Epidemiology; Ethnic group; Fetal health; Fire - disasters; Fostering; Future; Goals; Hazardous Waste Sites; Health; Historically Black Colleges and Universities; Hurricane; Individual; Industrialization; Infant; Infant Health; Institution; Knowledge; Leadership; Life; Maternal Health; Medicine; Metals; Mothers; Natural Disasters; Neighborhoods; Not Hispanic or Latino; Outcome; Perinatal; Physical environment; Pollution; Population; Positioning Attribute; Pregnancy; Pregnant Women; Premature Birth; Race; Research; Research Activity; Research Personnel; Research Project Grants; Resources; Risk; Role; Sampling; Second Pregnancy Trimester; Social Environment; System; Talents; Testing; Texas; Third Pregnancy Trimester; Universities; Woman; base; built environment; career development; college; deprivation; environmental justice; health disparity; health literacy; infant morbidity; innovation; interdisciplinary collaboration; low socioeconomic status; maternal morbidity; multidisciplinary; next generation; obstetric outcomes; pregnancy disorder; racial disparity; resilience; response; stressor

Despite the knowledge that pregnancy affects the health trajectory of both mother and child across the lifecourse, significant racial disparities exist. African-American (AA) women are at greatest risk for preterm birth and for dying from hypertensive disorders of pregnancy (HDP) than any other group in the U.S. To decipher what drives these disparities, we are proposing a new Environmental Health Disparities Maternal and Infant Environmental Health Riskscape (MIEHR) Research Center. The Goal of the MIEHR Research Center is to elucidate contributions of the biological, physical, social and built environments of the environmental riskscape to environmental health disparities in pregnant women and their infants. The Houston-based MIEHR leverages partnerships and strong institutional support from Baylor College of Medicine and Texas Southern University, the fourth largest historically black university in the U.S. Notably, Houston offers a microcosm for research at the intersection of environmental exposures and health disparities, with its diverse multi-ethnic and multi-racial population and documented environmental injustices. The city has the largest petrochemical complex in the U.S., numerous hazardous waste sites, no zoning and is at risk for natural and industrial disasters. The MIEHR Research Center has two synergistic Research Projects that build on a unique ongoing, perinatal database and biospecimen repository: the BCM Peribank. Project 1: The Environmental Riskscape, Disasters and Obstetric Outcomes will utilize an epidemiologic approach to identify differences in race-specific associations between the mixture of individual chemicals (i.e. polycyclic aromatic hydrocarbons and metals) and place-based stressors in the riskscape and preterm birth. This project will also examine the impact of Hurricane Harvey on racial disparities in these exposures. Project 2: Disparities Aware Classifiers for Maternal and Infant Health will use an “omics” approach to develop and validate disparity aware classifiers for preterm birth and HDP for AA and non-Hispanic White women. The classifiers will be built from data obtained at delivery and the predictive capability of these classifiers will then be tested in second trimester pregnant women. MIEHR activities will be informed by a Community Engagement and Dissemination Core, which will enhance environmental health literacy and capacity for sustainable initiatives that build community resilience. An Investigator Development Core will support innovative pilot research that will promote career development of talented investigators from health disparity populations and increase capacity for future environmental health disparities research. The Administrative Core will provide organizational and integration support for MIEHR investigators, institutions and engaged communities. The MIEHR Research Center will accomplish its goals in research, career development and community engagement with multidisciplinary and diverse teams of community and academic experts, interdisciplinary collaborations between synergistic research projects, activities that develop a diverse workforce and community engagement that fosters equitable community stakeholder interactions.

尽管知道怀孕会影响整个生命过程中母亲和儿童的健康轨迹，但 存在重大的种族分布。非裔美国人（AA）妇女的早产风险最大，对 与美国其他任何群体相比，死于怀孕的高血压疾病（HDP） 这些分布，我们提出了新的环境健康差异母亲和婴儿 环境健康风险景观（MIEHR）研究中心。 MIEHR研究中心的目标是 阐明环境风险景观的生物，物理，社会和建筑环境的贡献 孕妇及其婴儿的环境健康差异。总部位于休斯顿的Miehr杠杆 贝勒医学院和德克萨斯州南部大学的合作伙伴关系和强大的机构支持， 休斯敦尤其是美国第四大历史黑人大学，在 环境暴露与健康分布的交集与潜水员多种族和多种族 人口和记录的环境不公正现象。该市拥有最大的石化综合体 美国，有许多危险的废物地点，没有分区，并且有自然和工业灾难的风险。 Miehr 研究中心有两个协同的研究项目，这些项目以独特的持续围产期数据库为基础 生物循环存储库：BCM Peribank。项目1：环境风险景观，灾难和 产科结果将利用一种流行病学方法来识别种族特异性关联的差异 在单个化学物质（即多环芳烃和金属）的混合物和基于位置的混合物之间 风险景观和早产。该项目还将检查哈维飓风的影响 这些暴露的种族差异。项目2：孕产妇和婴儿健康的差异分类器 将使用一种“ OMICS”方法来开发和验证差异意识分类器的早产和HDP AA和非西班牙裔白人妇女。分类器将是根据交付时获得的数据和预测性构建的 然后，这些分类器的功能将在妊娠孕妇中进行测试。 Miehr活动将是 由社区参与和传播核心所告知，这将增强环境健康 可持续倡议的识字和能力，以建立社区弹性。研究人员的发展 核心将支持创新的试点研究，这将促进来自 健康差异人群并增加了未来环境健康差异研究的能力。这 行政核心将为MIEHR调查人员，机构提供组织和集成支持 和订婚社区。 Miehr研究中心将在研究中实现其目标，职业 与社区和学术的多学科和潜水团队的发展和社区参与 专家，协同研究项目之间的跨学科合作，发展潜水员的活动 促进公平社区利益相关者互动的劳动力和社区参与。