MACS/WIHS Combined Cohort Study: Brooklyn Clinical Research Site (Bklyn CRS)

MACS/WIHS 联合队列研究：布鲁克林临床研究中心 (Bklyn CRS)

• 批准号: 10370354
• 负责人: DEBORAH R. GUSTAFSON
• 金额: $ 278.67万
• 依托单位: SUNY DOWNSTATE MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-04-01 至 2026-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10370354
• 关键词: Achievement; Address; Adult; Affect; Age; Aging; Area; Behavioral; Biological; Blood Vessels; Brain imaging; Cardiovascular Diseases; Cardiovascular system; Caring; Central obesity; Cerebrovascular Disorders; Characteristics; Chronic; Chronic Obstructive Pulmonary Disease; Clinical; Cognition Disorders; Cohort Studies; Coupled; Data; Data Collection; Dementia; Development; Elderly; Enrollment; Ensure; Epidemiology; Fostering; Genetic; Geographic Locations; HIV; HIV Infections; Health; Impaired cognition; Infrastructure; Interdisciplinary Study; Leadership; Life Cycle Stages; Lung; Measures; Mental Depression; Mentors; Methods; Mission; Modeling; Molecular; Morbidity - disease rate; Neurocognition; Neurocognitive; Newly Diagnosed; Obesity; Older Population; Outcome; Participant; Pathogenesis; Peripheral; Personal Satisfaction; Phenotype; Policies; Positioning Attribute; Prevention approach; Prospective cohort; Protocols documentation; Reading; Recording of previous events; Research; Research Personnel; Resources; Risk; Risk Factors; Science; Scientist; Self Management; Sexual Health; Site; Sleep; Spirometry; Stroke; Syndrome; Testing; Time; Training; Training Support; Weight Gain; Woman; Women' s Interagency HIV Study; adjudication; aging brain; career development; chronic infection; clinical research site; cohort; community engagement; comorbidity; experience; follow-up; frailty; high standard; improved; innovation; men; middle age; multidisciplinary; next generation; participant retention; protective factors; psychologic; psychosocial; pulmonary function; recruit; sleep quality; sleep quantity; social; substance use; urban underrepresented; vascular risk factor

PROJECT SUMMARY This project will establish and implement the Brooklyn Clinical Research Site (Bklyn CRS) of the MACS/WIHS Combined Cohort Study (MACS/WIHS CCS) and support its mission to advance the clinical, behavioral, and epidemiological science of newly diagnosed and chronic HIV infection and associated comorbidities. The Bklyn CRS evolves from and builds upon a 25-year history of scientific innovation accompanied by community engagement that facilitated rigorous implementation of the Brooklyn Women's Interagency HIV Study (WIHS). The Bklyn CRS will rapidly develop a diverse cohort of men and women reflecting the unique characteristics of HIV in our geographic area. We will include continued follow-up of WIHS participants, who contribute a rich longitudinal history of clinical, biologic, genetic, psychosocial and behavioral data derived from midlife and younger ages, informing questions of HIV and aging in an older population. The Bklyn CRS investigators will develop and implement protocols of the MACS/WIHS CCS Unified Science Agenda, contribute to the overall functioning of the administrative infrastructure, and engage a strong and multidisciplinary team of researchers in addressing innovative science. Our specific aims are to: 1) recruit and retain a prospective cohort of 500 men and women living with HIV and matched seronegative controls and implement MACS/WIHS CCS study protocols; 2) engage a multidisciplinary and experienced team of scientists to develop and implement innovative research that aligns with and advances the CCS Unified Science Agenda; and 3) provide training and career development opportunities to support advancement of the next generation of HIV researchers. The Bklyn CRS provides scientific, administrative and collaborative leadership in cardiovascular disease and associated lung and sleep outcomes; aging via physical, functional and molecular assessments; psychological and social environmental aspects of self-management of HIV and associated co-morbidities; and neurocognition and brain aging. As such, the Bklyn CRS will greatly enhance the MACS/WIHS CCS, ensuring the rigor and relevance of study questions and methods to address those questions.

项目摘要 该项目将建立并实施Mac/WIHS的Brooklyn临床研究网站（BKLYN CRS） 组合研究（MAC/WIHS CCS）并支持其推进临床，行为和 新诊断和慢性HIV感染以及相关合并症的流行病学科学。 Bklyn CRS从社区伴随着25年的科学创新历史发展，并建立在社区的历史上 促进了布鲁克林妇女间艾滋病毒研究（WIHS）的严格实施的参与。 Bklyn CRS将迅速发展各种各样的男人和女人，以反映出的独特特征 艾滋病毒在我们的地理区域。我们将继续对WIHS参与者进行持续跟进，他们贡献了富人 临床，生物学，遗传，社会心理和行为数据的纵向历史，来自中年和 年轻的年龄，在老年人群中告知艾滋病毒和衰老的问题。 BKLYN CRS调查人员将 制定和实施Mac/WIHS CCS统一科学议程的协议，有助于总体 行政基础设施的运作，并参与一个强大而多学科的研究人员 在解决创新科学方面。 我们的具体目的是：1）招募和保留500名艾滋病毒和妇女的前瞻性队列 匹配的血清调控并实施MAC/WIHS CCS研究方案； 2）参与 多学科和经验丰富的科学家团队，开发和实施与一致的创新研究 随着CCS统一科学议程的发展； 3）提供培训和职业发展 支持下一代艾滋病毒研究人员进步的机会。 Bklyn CRS在心血管疾病和 相关的肺和睡眠结局；通过物理，功能和分子评估衰老；心理 以及艾滋病毒和相关合并症自我管理的社会环境方面；和 神经认知和大脑衰老。因此，Bklyn CRS将大大增强Mac/WIHS CCS，以确保 研究问题和方法的严格和相关性解决这些问题。