Obesity and Alzheimer's Disease

肥胖和阿尔茨海默病

• 批准号: 7241454
• 负责人: DEBORAH R. GUSTAFSON
• 金额: $ 6.25万
• 依托单位: MEDICAL COLLEGE OF WISCONSIN
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-07-01 至 2009-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7241454
• 关键词: Adult; Age; Aged, 80 and over; Aging; Alteplase; Alzheimer' s Disease; Alzheimer' s disease risk; Angiotensin Receptor; Angiotensins; Apolipoprotein E; Area; Birth; Blood Pressure; Blood Vessels; Body Weight; Body mass index; Brain Pathology; Catechols; Cessation of life; Clinical; Data; Dementia; Disease; Disruption; Elderly; Energy Metabolism; Epidemic; Etiology; Europe; Evaluation; Feminization; Future; Genes; Genetic; Genetic Polymorphism; Genotype; Goals; Health; Homeostasis; Hormones; Hunger; Hypothalamic structure; Length; Life Cycle Stages; Longevity; Longitudinal Studies; Measurement; Mental disorders; Methylenetetrahydrofolate reductase (NADPH); Morbidity - disease rate; Obesity; Onset of illness; Overweight; Participant; Pattern; Peptidyl-Dipeptidase A; Physical activity; Population; Population Study; Prevalence; Publications; Rate; Regulation; Relative (related person); Reporting; Research; Risk; Risk Factors; Role; Satiation; Societies; Sweden; Time; Transferase; United States; Variant; Weight; Woman; age group; age related; base; blood lipid; cohort; critical developmental period; design; follow-up; genetic risk factor; intervention program; men; mortality; neuropathology; prospective; Adult; Age; Aged, 80 and over; Aging; Alteplase; Alzheimer' s Disease; Alzheimer' s disease risk; Angiotensin Receptor; Angiotensins; Apolipoprotein E; Area; Birth; Blood Pressure; Blood Vessels; Body Weight; Body mass index; Brain Pathology; Catechols; Cessation of life; Clinical; Data; Dementia; Disease; Disruption; Elderly; Energy Metabolism; Epidemic; Etiology; Europe; Evaluation; Feminization; Future; Genes; Genetic; Genetic Polymorphism; Genotype; Goals; Health; Homeostasis; Hormones; Hunger; Hypothalamic structure; Length; Life Cycle Stages; Longevity; Longitudinal Studies; Measurement; Mental disorders; Methylenetetrahydrofolate reductase (NADPH); Morbidity - disease rate; Obesity; Onset of illness; Overweight; Participant; Pattern; Peptidyl-Dipeptidase A; Physical activity; Population; Population Study; Prevalence; Publications; Rate; Regulation; Relative (related person); Reporting; Research; Risk; Risk Factors; Role; Satiation; Societies; Sweden; Time; Transferase; United States; Variant; Weight; Woman; age group; age related; base; blood lipid; cohort; critical developmental period; design; follow-up; genetic risk factor; intervention program; men; mortality; neuropathology; prospective

DESCRIPTION (provided by applicant): Obesity is associated with Alzheimer's disease (AD), particularly in women. However, changes in body weight and body mass index (BMI) throughout the progressive course of AD have also been reported, resulting in a low body weight or low BMI predicting mortality among those who have the disease. Thus, temporal changes in body weight and BMI may not only influence AD risk, but also progression, and ultimately death. The role of BMI in AD also underscores the importance of timing of risk factors, both in relationship to disease onset and whether they occur in early-, mid-, or late-life; and illustrates the change in direction of risk factor-disease relationships that may occur at certain points in late life. The goals of this project are to evaluate the role of BMI and related vascular and genetic factors in relationship to AD in three population-based, longitudinal studies containing epidemiologic, clinical, and biologic data related to psychiatric disorders of aging that are unsurpassed in the world. We propose to: 1) Characterize the role of overweight and obesity in AD and other dementias in women and men across three population-based studies in Goteborg, Sweden. Participants in these studies, born between 1901 and 1930, have been followed prospectively from baseline ages of 38 to 70, and 95 years. 2) Evaluate the role of overweight and obesity in AD and other dementias with consideration for 'critical periods' of adiposity exposure, the length of time between an adiposity measurement and onset of dementia, the role of current overweight and obesity outpoints in relationship to dementia risk, and examination of risk factors by age group with consideration for birth cohort. 3) Assess the role of genetic polymorphisms related to the vascular etiology of AD and other dementias, and their potential interaction with obesity. 4) Consider physical activity and other vascular risk factors, such as blood pressure and blood lipids, and their potential interaction with obesity and genetic factors to modulate risk for AD and other dementias. Understanding the life course of overweight and obesity in relationship to dementia will assist the future design of tailor-made intervention programs based on age and previous weight patterns, and assist in the evaluation of better outpoints for overweight and obesity that optimize health in the oldest age groups.

描述（由申请人提供）：肥胖与阿尔茨海默氏病（AD）有关，尤其是在女性中。然而，在整个AD进行的整个过程中，体重和体重指数（BMI）的变化也据报道，导致体重低或BMI低的BMI预测患有该疾病的患者的死亡率。因此，体重和BMI的时间变化不仅可能影响AD风险，而且会影响进展，最终会影响死亡。 BMI在AD中的作用也强调了危险因素时间的重要性，无论是与疾病发作关系以及它们是否发生在早期，中期或后期生活中；并说明了后期生活可能发生的风险因素 - 疾病关系方向的变化。该项目的目标是评估BMI和相关的血管和遗传因素与AD关系中的作用，在三项基于人群的纵向研究中，含有与世界无与伦比的衰老精神疾病有关的流行病学，临床和生物学数据。我们建议：1）在瑞典哥德堡的三项基于人群的研究中，超重和肥胖在AD和其他痴呆症中的作用。这些研究的参与者是1901年至1930年之间出生的。 2）评估超重和肥胖在AD和其他痴呆症中的作用，并考虑肥胖暴露的“关键时期”，肥胖度量测量和痴呆症发作之间的时间长度，当前超重和肥胖含点与痴呆症风险相关的超重和肥胖含量的作用以及与年龄群体相关的痴呆症风险的检查，并考虑了对出生人群的考虑。 3）评估与AD和其他痴呆症血管病因相关的遗传多态性的作用，以及它们与肥胖症的潜在相互作用。 4）考虑体育活动和其他血管危险因素，例如血压和血脂，以及它们与肥胖和遗传因素的潜在相互作用，以调节AD和其他痴呆症的风险。了解与痴呆症关系的超重和肥胖的生活过程将帮助未来根据年龄和以前的体重模式设计量身定制的干预计划，并协助评估更好的超重和肥胖，以优化最古老的年龄段的健康。