Modernization and Expansion of the University of Illinois at Chicago Animal-Based Research Program

伊利诺伊大学芝加哥分校动物研究项目的现代化和扩展

• 批准号: 10374588
• 负责人: Joanna Louise Groden
• 金额: $ 674.91万
• 依托单位: UNIVERSITY OF ILLINOIS AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-20 至 2026-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10374588
• 关键词: Air Conditioning; Animal Experimentation; Animals; Area; Biological; Cancer Center; Cancer Patient; Cardiovascular Diseases; Caring; Chicago; Clinical; Clinical Research; Clinical Sciences; Communities; Disease; Elements; Entrepreneurship; Funding; Growth; Heating; Hospitals; Housing; Illinois; Institutes; Institution; Laboratories; Laboratory Animal Production and Facilities; Laboratory Animals; Link; Malignant Neoplasms; Metabolic; Metabolic Diseases; Mission; Modeling; Modernization; Mus; Organoids; Patients; Population Heterogeneity; Population Research; Pre-Clinical Model; Research; Resources; Sampling; Strategic Planning; System; Translational Research; United States National Institutes of Health; Universities; Xenograft Model; animal facility; base; clinical center; drug discovery; health disparity; human disease; human model; minority health; novel therapeutics; patient population; precision medicine; programs; treatment disparity; ventilation

Abstract The University of Illinois at Chicago (UIC) has developed highly recognized programs in health disparity research and is a national leader among urban, public institutions that provide care for diverse patient populations through its hospital and community-based clinical systems. Our UIC research programs have developed around our diverse populations and communities with a focus on understanding disease mechanisms, developing novel therapeutics and refining clinical approaches that have relevance to our patient base. Our preclinical modeling capability and laboratory animal research facilities now require expansion to link our research opportunities with the capability to generate and characterize models of human disease that support our core mission areas. UIC proposes to modernize and expand its animal-based research programs by performing critical renovations to the Biologic Resources Laboratory (BRL), the institution’s centralized animal facility. The project will comprise renovations and upgrades to essential elements of the heating ventilation and air conditioning (HVAC) and electrical systems in the BRL to increase housing capacity and accommodate growth in the institution’s murine- based cancer and metabolic research programs. These include a patient-derived organoid and xenograft modeling core that uses samples from underrepresented cancer patient populations and a new Metabolic Disease Core to model health disparities in the treatment of cardiovascular and metabolic diseases. Such modernization will also result in significant energy efficiencies. Overall, UIC BRL improvements will support animal-based research and permit the expansion of our translational and clinical research programs in health disparities and drug discovery. The long-term impact of the UIC BRL expansion will sustain our programs of translational excellence in health disparities research and drug discovery while permitting the growth of our NIH- funded population-based research programs (All of Us within the Illinois Precision Medicine Consortium, UIC Institute for Minority Health Research, and our CTSA-supported Center for Clinical and Translational Sciences) and our UI Cancer Center. This expansion will also impact the research programs of our regional partners who rely upon our facilities, cores and capability in animal research. Finally, our entrepreneurship-based strategic plan and for-profit partnerships to drive drug discovery initiatives have also compelled the expansion of our animal-based preclinical modeling capabilities.

抽象的 伊利诺伊大学芝加哥大学（UIC）开发了健康差异研究方面的知名计划 并且是城市公共机构中的国家领导者，通过 它的医院和基于社区的临床系统。我们的UIC研究计划已经围绕我们 多样化的人群和社区，专注于理解疾病机制，发展新颖 与我们的患者基础相关的治疗疗法和精炼临床方法。我们的临床前建模 现在的能力和实验室动物研究设施现在需要扩展将我们的研究机会与 产生和表征支持我们核心任务领域的人类疾病模型的能力。 UIC 通过对基于动物的研究计划进行现代化和扩展其基于动物的研究计划的建议 该机构的集中动物设施生物资源实验室（BRL）。该项目将完成 翻新和升级到加热通气和空调（HVAC）的基本要素和 BRL中的电气系统增加了该机构鼠的住房能力和住宿的增长 - 基于癌症和代谢研究计划。这些包括患者衍生的类器官和异种移植 建模核心使用代表性不足的癌症患者人群和新代谢的样品 疾病核心，以对心血管和代谢疾病的治疗中的健康差异进行建模。这样的 现代化也将导致明显的能源效率。总体而言，UIC BRL的改进将支持 基于动物的研究并允许扩大我们的转化和临床健康研究计划 差异和药物发现。 UIC BRL扩展的长期影响将维持我们的计划 健康差异研究和药物发现方面的转化卓越，同时允许我们的NIH增长 基于人群的研究计划（我们所有人都在伊利诺伊州伊利诺伊州精密医学联盟中 少数民族健康研究所以及我们的CTSA临床和转化科学中心） 和我们的UI癌症中心。这种扩展还将影响我们区域合作伙伴的研究计划 依靠我们的设施，核心和动物研究中的能力。最后，我们基于企业家的战略 计划和营利性合作伙伴关系推动药物发现计划也迫使我们的扩张 基于动物的临床前建模功能。