Improving Air Quality for Laboratory Animal Research

改善实验动物研究的空气质量

• 批准号: 7935043
• 负责人: Sharron S Quisenberry
• 金额: $ 438.31万
• 依托单位: IOWA STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-03-25 至 2013-03-24
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7935043
• 关键词: Accreditation; Air; Air Conditioning; Animal Experimentation; Animal Housing; Animals; Biomedical Research; Centers for Disease Control and Prevention (U.S.); Communication; Data; Development; Disease; Elements; Emergency Situation; Ensure; Environment; Foundations; Funding; Funding Agency; Goals; HIV-1; Heating; Housing; Human Resources; Humidity; IACUC; Iowa; Knock-out; Laboratory Animals; Malignant Neoplasms; Mechanics; Odors; Parkinson Disease; Production; Research Personnel; Research Support; Role; Scientist; Spinal Muscular Atrophy; System; Transgenic Mice; United States National Institutes of Health; Universities; Veterinary Medicine; aged; animal care; animal resource; computerized; design; falls; foodborne illness; human disease; improved; meetings; mouse model; programs; sound; square foot

DESCRIPTION (provided by applicant): Iowa State University proposes to bring up to accreditation standards the under-designed HVAC (heating, ventilating and air conditioning) system in 12,697 net square feet (21,162 gross square feet) of the unit called the "Central Facility." Located on the southeast corner of the campus, the Central Facility is an essential element of the university's Laboratory Animal Resources Core and supports the research of over 15 NIH- funded scientists across campus as well as programs funded by agencies such as DOE, USDA, CDC and private foundations. It also houses several knockout and transgenic mouse models of human diseases. The Specific Aim of the proposal is the renovation of the HVAC system. The proposal has three Scientific Merit goals: the production of high-quality laboratory animal space, the development of facilities that optimize the recruitment and retention of NIH-supported researchers, and accreditation of the university's Laboratory Animal Resources Core by the Association for the Assessment and Accreditation of Laboratory Animal Care (AAALAC). The aim and goals are synergistic; together they will ensure high quality animal space so researchers can obtain reliable results and produce significant data to increase the basic understanding of diseases such as Parkinson's disease, spinal muscular atrophy, cancer, HIV-1 and food borne illnesses. The last major overhaul of the HVAC system in the 30 year-old Central Facility was in 1994. Although the building is structurally sound, the mechanical system is aged, energy inefficient and is connected to the air handling system used for the offices and classrooms in the Veterinary Medicine Building. The Central Facility continues to meet USDA standards for animal housing. However, it has recently been cited by the Institutional Animal Care and Use Committee (IACUC) for reduced air flow, improper directional air flow, and low humidity deficiencies. In addition, an AAALAC pre-review last fall expressed concerns about air quality, the need for greater air exchange, and "excessive odors." Renovation of the HVAC system in the Central Facility will include addition of a new heating, ventilating and air conditioning system, independent of the current system that also serves offices and classrooms. The new system will provide humidification, improved filtering, and redundancy that the current system lacks. The proposed system will also include a new emergency generator, computerized controls and backup chiller. The Project Management Plan for the HVAC renovation is designed to ensure that the Specific Aim and the Scientific Merit goals dovetail to produce a high-quality environment for successful biomedical research. Each of the Key Personnel has a well-defined role in the Project Management Plan and explicit mechanisms for their interaction are set forth. A Project Liaison Officer will assist with communications and coordination among the key scientists and other Key Personnel.

描述（由申请人提供）：爱荷华州立大学提出符合认证标准，该标准较高设计的HVAC（供暖，通风和空调）系统，净平方英尺为12,697净平方英尺（21,162平方英尺），称为“中央设施”。中央设施位于校园的东南角，是大学实验室动物资源核心的重要组成部分，并支持对校园的15多名NIH资助科学家以及由DOE，USDA，CDC和私人基金会等机构资助的计划。它还容纳了人类疾病的几种敲除和转基因小鼠模型。 该提案的具体目的是对HVAC系统的翻新。该提案具有三个科学优点目标：高质量实验室动物空间的生产，开发优化NIH支持的研究人员的招募和保留的设施，以及通过对实验室动物护理评估和认证协会（AAAALAC评估和认证）对大学实验室动物资源核心的认证。目标和目标是协同作用的；它们将共同确保高质量的动物空间，以便研究人员可以获得可靠的结果并产生重要的数据，以增加对帕金森氏病，脊髓肌肉萎缩，癌症，HIV-1和食物出现疾病等疾病的基本了解。 HVAC系统在30年历史的中央设施中进行的最后一次重大大修是在1994年。尽管该建筑物在结构上是合理的，但机械系统是老化的，能源效率低下，并且与用于兽医医学大楼办公室和教室的空气处理系统相连。中央设施继续符合美国农业部的动物住房标准。但是，最近，机构动物护理和使用委员会（IACUC）引用了它，以减少空气流量，定向气流不当和湿度不足。此外，去年秋天的AAAALAC预报对空气质量，更大的空气交换需求和“气味过多”表示担忧。 HVAC系统在中央设施中的翻新将包括添加新的供暖，通风和空调系统，该系统与当前还提供办公室和教室的当前系统无关。新系统将提供当前系统所缺乏的加湿，改进的过滤和冗余。拟议的系统还将包括新的应急发电机，计算机控件和备用冷却器。 HVAC翻新的项目管理计划旨在确保特定的目标和科学功绩目标为成功的生物医学研究提供高质量的环境。每个关键人员在项目管理计划中都有明确的作用，并阐明了其互动的明确机制。一个项目联络官将协助关键科学家和其他关键人员之间进行沟通和协调。